Abstract: Defined herein are immunomodulating Formula (1) compounds stereoisomers thereof, and pharmaceutically acceptable salts thereof; wherein R0, R1, R2, R10, W, Ring C and n are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Abstract: Defined herein are immunomodulating Formula (1) compounds, wherein R, R0, R1, R2 and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating or preventing an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, or pharmaceutically acceptable salt thereof; or use of said Formula (1) compound to prepare a medicament for treating or preventing an inflammatory and/or immunological disease or disorder in an animal.

Abstract: An Artificial Reality (AR) device captures an image of a physical environment surrounding a user wearing the AR device. A three-dimensional map corresponding to the physical environment is accessed. Then, a pose of the AR device relative to the three-dimensional map is determined based on first features of physical objects captured in the image and second features of object representations in the three-dimensional map. The device determines, using an eye tracker, a gaze of an eye of the user. Based on the gaze and the pose, a region of interest is computed in the three-dimensional map. Representations of physical devices in the region of interest of the three-dimensional map are identified. The device determines an intent of the user to interact with a physical device. A command is issued to the physical device based on the determined intent.

Abstract: A method for artificial intelligence (AI) event response includes receiving an event alert or a communication associated with an event alert from a communication device. The method includes an AI system collecting additional information about at least one of the event alert, the communication device, or a user of the communication device. The method includes the AI system categorizing the event alert into one category of multiple categories based on the collected additional information. The method includes prioritizing subsequent handling of the event alert among other event alerts based on the category.

Abstract: In one embodiment, a computing system instructs, at a first time, a camera having a plurality of pixel sensors to use the plurality of pixel sensors to capture a first image of an environment comprising an object. The computing system predicts, using at least the first image, a projection of the object appearing in a virtual image plane associated with a predicted camera pose at a second time. The computing system determines, based on the predicted projection of the object, a first region of pixels and a second region of pixels. The computing system generates pixel-activation instructions for the first region of pixels and the second region of pixels. The computing system instructs the camera to capture a second image of the environment at the second time according to the pixel-activation instructions.

Abstract: A retention mechanism for retaining an agricultural machine in engagement with a fork assembly. The mechanism may be provided on the fork assembly, agricultural machine or split between them. The retention mechanism may be actuated by a foot associated with either the fork assembly or the agricultural machine. The retention mechanism may employ pivoting latches or a clamping mechanism that clamps upon the forks or tines.

Abstract: In one embodiment, a method includes accessing a digital image captured by a camera that is connected to a machine-detectable object, detecting a reflection of the machine-detectable object in the digital image, computing, in response to the detection, a plane that is coincident with a reflective surface associated with the reflection, determining a boundary of the reflective surface in the plane based on at least one of a plurality of cues, and storing information associated with the reflective surface, where the information includes a pose of the reflective surface and the boundary of the reflective surface in a 3D model of a physical environment, and where the information associated with the reflective surface and the 3D model are configured to be used to render a reconstruction of the physical environment.

Abstract: A head-mounted display system may include a wearable frame securable to a user's head. The head-mounted display system may also include a mapping subsystem that maps a local environment of the user when the wearable frame is secured to the user's head. Additionally, the head-mounted display system may include a varifocal display apparatus mounted to the wearable frame and configured to direct computer-generated images toward the user's eyes at a variable focal length. Various other apparatuses, systems, and methods are also disclosed.

Abstract: A system for allowing product managers and software engineers to search for existing software modules that meet desired parameters and to identify opportunities to develop new software modules is provided. When product developer creates a software component they assign combinations of tags to the software component in a predetermined format and structure that describes features of the component such as the entity that would use the component, actions that are performed by the component, objects used by the component, and desired outcomes of the component. These tags are associated with the software component in the system. Later, when a developer has a need or idea for a particular component, the developer uses the system to construct a sentence that describes the features of the component as described above. The system then identifies any existing components that match or are close matches to the described component.

Abstract: Antimicrobial peptides of general formula X0X1X2CX3X4X5CX6X7X8X9CYX10X11CX12X13 are provided. Also provided are certain formulations containing these peptides and methods of using these peptides for treating skin infections in an animal in need thereof.

Abstract: A cured-in-place pipe rehabilitation device launcher having a launcher assembly and a liner assist chamber, the launcher assembly includes a nozzle, an air feed chamber above the nozzle to pressurize a cured-in-place liner to aid in urging it into a pipe to be rehabilitated, and an attachment plate is disposed above the adapter. The liner assist chamber includes a base plate to attach to the attachment plate, a liner assist frame coupled to the base plate, a plurality of rollers rotationally attached to the liner assist frame, and a motor operably attached to at least one of the plurality of rollers and configured to aid in urging the cured-in-place liner into the pipe.

Abstract: A method and apparatus for positioning a camera to capture images inside a body cavity of a patient during a medical procedure is disclosed. The apparatus includes an insertion tube, a plurality of connected linkages extending from a distal end of the insertion tube, each linkage having a threaded actuator received on a threaded end of a drive shaft extending between the threaded actuator and a proximal end of the insertion tube. The apparatus also includes a camera disposed at a distal end of the plurality of connected linkages. Each connected linkage has at least one associated movement actuated by movement of the threaded actuator in response to rotation of the drive shaft, the associated movements of the connected linkages together operable to facilitate positioning of the camera within the body cavity of the patient.

Abstract: In one embodiment, a method includes instructing, at a first time, a camera having a plurality of pixel sensors to capture a first image of an environment comprising an object to determine a first object pose; determining, based on the first object pose, a predicted object pose of the object at a second time; generating pixel-activation instructions based on a buffer region around a projection of a 3D model of the object having the predicted object pose onto a virtual image plane associated with a predicted camera pose, where the size of the buffer region may be dependent on predicted dynamics for the object; instructing, at the second time, the camera to use a subset of the plurality of pixel sensors to capture a second image of the environment according to the pixel-activation instructions, and; determining, based on the second image, a second object pose of the object.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: Disclosed are methods, systems and devices for storing states in a memory in support of applications residing in a trusted execution environment (TEE). In an implementation, one or more memory devices accessible by a memory controller may be shared between and/or among processes in an untrusted execution environment (UEE) and a TEE.

Abstract: A system and apparatus for assisting in determining the best course of action at any point inflight for an emergency. The system may monitor a plurality of parameters including atmospheric conditions along the flight path, ground conditions and terrain, conditions aboard the aircraft, and pilot/crew data. Based on these parameters, the system may provide continually updated information about the best available landing sites or recommend solutions to aircraft configuration errors. In case of emergency, the system may provide a procedure associated with a hierarchy of available emergency landing sites for execution via the autopilot system for landing the aircraft.

Abstract: An integrated circuit comprises a power input, digital logic circuitry, a plurality of charge stores, and obscuring circuitry. The charge stores are configured to receive power from the power input, are distributed through the digital logic circuitry and are capable of providing power to the digital logic circuitry. The obscuring circuitry is configured to obscure electromagnetic emissions associated with flow of current in current loops between the plurality of charge stores and the digital logic circuitry by switching between a plurality of different charge store activation patterns, wherein each charge store activation pattern describes a different selection of one or more of the plurality of charge stores providing power to the digital logic circuitry at a given time.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Apparatus and associated methods relate to measuring position and displacement of a 2D surface magnet array of at least three adjacent magnetic north and south tracks with an acute angle versus its motion displacement relative to a magnetic field sensor (e.g., magnetic sensing probe). In an illustrative example, the geometry of the 2D surface magnet array may be planar with adjacent and alternating north and south pole regions. In some embodiments, the 2D surface magnet array geometry may take the form of (1) an axial cylindrical helical multipole magnet array having individually magnetized layers that are oriented in helical shape, or (2) a radial disk spiral multipole magnet array with at least three adjacent north and south tracks oriented as a spiral shape.

Abstract: A method, to navigate a video editing project within a video editing application, includes storing a project timeline comprising a plurality of media content items arranged in a chronological sequence, the project timeline having a start time and an end time; causing presentation of a first tool interface, the first tool interface comprising: a video editing canvas for playback of the project timeline; a plurality of tools to enable respective video editing functions; and a plurality of indicia representing the respective plurality of media content items; detecting activation of a first indicium associated with a first media content item of the plurality of media content items; and advancing the playback of the project timeline to a chronological location corresponding to the location of the first media content item within the project timeline.