Patents by Inventor Richard B. Silverman

Richard B. Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20170349552
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Yinan Zhang
  • Treatment of amyotrophic lateral sclerosis
    Patent number: 9809556
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: November 7, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Yinan Zhang
  • Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
    Patent number: 9802942
    Abstract: Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may contain a fluorophore or may be conjugated to a fluorophore in order to prepare a fluorescent probe for use in high throughput screening methods to identify new modulators of glucocerebrosidase activity via fluorescence polarization.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 31, 2017
    Assignee: Northwestern University
    Inventors: Dimitri Krainc, Richard B. Silverman, Jianbin Zheng
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20170298021
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 19, 2017
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
    Patent number: 9783500
    Abstract: Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: October 10, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Maris A. Cinelli, Anthony V. Pensa
  • Mammalian and Bacterial Nitric Oxide Synthase Inhibitors
    Publication number: 20170275278
    Abstract: Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with NOS activity.
    Type: Application
    Filed: April 7, 2017
    Publication date: September 28, 2017
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Heng-Yen Wang, Yajuan Qin, Fengwei Zou, Soo Sung Kang, Qing Jing
  • Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
    Patent number: 9765055
    Abstract: Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: September 19, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase
    Publication number: 20170260165
    Abstract: Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase.
    Type: Application
    Filed: May 23, 2017
    Publication date: September 14, 2017
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Paramita Mukherjee, Hien M. Nguyen
  • Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
    Patent number: 9758507
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: September 12, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and Related Compounds as GABA Aminotransferase Inactivators for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma
    Publication number: 20170239202
    Abstract: Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 24, 2017
    Inventors: Richard B. Silverman, Kenji Takaya, Hoang V. Le, Jose I. Juncosa
  • 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9732037
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 15, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
    Patent number: 9701661
    Abstract: Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: July 11, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Paramita Mukherjee, Hien M. Nguyen
  • Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9682950
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: June 20, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma
    Patent number: 9670141
    Abstract: Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: June 6, 2017
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Richard B. Silverman, Kenji Takaya, Hoang V. Le, Jose I. Juncosa
  • 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
    Patent number: 9663468
    Abstract: Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: May 30, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Maris A. Cinelli, Anthony V. Pensa
  • (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and Related Compounds as GABA Aminotransferase Inactivators for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma
    Publication number: 20170101364
    Abstract: Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
    Type: Application
    Filed: October 10, 2016
    Publication date: April 13, 2017
    Inventors: Richard B. Silverman, Kenji Takaya, Hoang V. Le, Jose I. Juncosa
  • Ornithine aminotransferase inhibition with GABA analogues for treatment of hepatocellular carcinoma
    Patent number: 9603820
    Abstract: Therapeutic methods relating to the use of GABA-AT inhibitor compounds for the treatment of hepatocellular carcinoma.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: March 28, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Yaron Ilan
  • Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
    Patent number: 9593069
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: March 14, 2017
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Benzamide Compounds and Related Methods of Use
    Publication number: 20170050926
    Abstract: Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
    Type: Application
    Filed: June 20, 2016
    Publication date: February 23, 2017
    Inventors: Richard B. Silverman, Hua Wang, Mohammad Khanfar, Aleksey G. Kazantsev
  • SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY
    Publication number: 20170002013
    Abstract: Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may contain a fluorophore or may be conjugated to a fluorophore in order to prepare a fluorescent probe for use in high throughput screening methods to identify new modulators of glucocerebrosidase activity via fluorescence polarization.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Applicant: Northwestern University
    Inventors: Dimitri Krainc, Richard B. Silverman, Jianbin Zheng