Abstract: The present invention relates to pharmaceutical compositions and methods useful for the treatment of dermatological disorders, and in particular acne vulgaris and skin pigmentation disorders. Pharmaceutical compositions comprising one or more arginine, salicylic acid and/or azelaic acid that are useful for the treatment of dermatological diseases and the symptoms and underlying causes of such dermatological diseases are also disclosed.

Abstract: A field effect transistor semiconductor device having a compact device footprint for use in automotive and hot swap applications. The device includes a plurality of field effect transistor cells with the plurality of transistor cells having at least one low threshold voltage transistor cell and at least one high threshold voltage transistor cell arranged on a substrate. The field effect transistor semiconductor device is configured and arranged to operate the at least one high threshold voltage transistor cell during linear mode operation, and operate both the low threshold voltage transistor cell and the high threshold voltage transistor cell during resistive mode operation. Further provided is a method of operating field effect transistor semiconductor device including a plurality of field effect transistor cells that includes at least one low threshold voltage transistor cell and at least one high threshold voltage transistor cell.

Abstract: The present invention relates to, among other things, methods and systems for recognizing and characterizing protein aggregation processes at the earliest possible time and use of such new methods and systems for (1) the identification and selection of protein formulations that minimize aggregation and extend long-term stability and (2) the identification of protein variants with the lowest tendency to aggregate.

Abstract: Genomic references are structured as a reference graph that represents diploid genotypes in organisms. A path through a series of connected nodes and edges represents a genetic sequence. Genetic variation within a diploid organism is represented by multiple paths through the reference graph. The graph may be transformed into a traversal graph in which a path represents a diploid genotype. Genetic analysis using the traversal graph allows an organism's diploid genotype to be elucidated, e.g., by mapping sequence reads to the reference graph and scoring paths in the traversal graph based on the mapping to determine the path through the traversal graph that best fits the sequence reads.

Abstract: A battery cell assembly includes a pouch-type battery cell having a battery member, an external housing, and first and second electrical terminals. The external housing has a central housing portion and a peripheral lip member extending around a periphery of the central housing portion. The central housing portion encloses the battery member therein. The first and second electrical terminals are electrically coupled to the battery member and extend outwardly from the peripheral lip member. The assembly further includes a first tube disposed against the peripheral lip member of the external housing. The peripheral lip member extends around the first tube such that the first tube is at least partially disposed within a first interior region defined by the peripheral lip member.

Abstract: A surface mount semiconductor device and method of manufacture. A semiconductor die is mounted on a first support surface; a leadframe is attached to the semiconductor die, the leadframe comprising: an electrical lead having a first lead region connected to the semiconductor die; and a second lead region distal the first lead region, wherein the second lead region is connected to a second support surface; encapsulating the semiconductor die, first support surface and the first lead region; the second lead region is severed from the second support surface to expose a lead end; and the second lead region is electro-plated with a metallic material, such that the lead end is coated with said metallic material.

Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Abstract: A method includes receiving a sample. The method also includes applying a denaturing agent to a first portion of the sample, and detecting, in response to the application of the denaturing agent, a first measure from the first portion of the sample. The method also includes modifying the temperature of a second portion of the sample and detecting, in response to the modifying the temperature of the second portion of the sample, a second measure from the second portion of the sample. The method also includes computing thermodynamic information for the sample based on the indication of the first measure, and computing kinetic information for the sample based on the indication of the second measure. The method also includes computing, based on the thermodynamic information and the kinetic information, an indication of temporal stability of the protein component of the sample.

Abstract: The present invention relates to pharmaceutical compositions and methods useful for the treatment of dermatological disorders, and in particular acne vulgaris and skin pigmentation disorders. Pharmaceutical compositions comprising one or more arginine, salicylic acid and/or azelaic acid that are useful for the treatment of dermatological diseases and the symptoms and underlying causes of such dermatological diseases are also disclosed.

Abstract: A video storage apparatus is described which stores and provides access to a video sequence of images. The apparatus comprises an array of storage devices, each image in the sequence being stored on at least one of the storage devices in the array, or being distributed across the array of storage devices with each portion being independently reproducible. A driver is provided, the driver being operable to access the video sequence by reading images in time order from the array of storage devices, temporally adjacent ones of the images, or different portions of the same image, being read by the driver from different storage devices in the array. In this way, an array of independent drives can be used to store video and allow much faster access to the stored video than would be the case with a single drive, and in a way which is more robust to drive failure.

Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Abstract: The present invention provides filter assemblies, tuning elements and a method of tuning a filter. A filter assembly includes a housing having a top cover, a bottom cover and at least one sidewall, the top cover, the bottom cover and the at least one sidewall defining an internal cavity, the housing configured to receive first through third radio frequency (“RF”) transmission lines; a top metal sheet mounted within the internal cavity that has a plurality of openings that form a first hole pattern; and a bottom metal sheet mounted within the internal cavity that has a plurality of openings that form a second hole pattern. The top and bottom metal sheets are vertically spaced-apart from each other in a vertically stacked relationship within the internal cavity. The top metal sheet and the bottom metal sheet each include at least one resonator.

Abstract: A system for detecting valvular malfunction includes a monitoring device and a processor. The monitoring device includes a heart sound sensor configured to detect heart sounds of the patient, and a signal processor. The processor is configured to receive a signal representative of the detected heart sounds from the signal processor, wherein the processor is configured to compare the signal to a baseline signal stored in memory. The processor may be part of the monitoring device or may be part of an external device, or both.

Abstract: A method for a Diffie Hellman key exchange, the method including selecting a field size p in the form p=hq+1, where q is a prime number that is one plus a factorial number b, such that q=(b!+1), and h is a cofactor, such that p=hq+1 is prime; selecting a generator integer g whose order modulo p is the prime q or is divisible by q; choosing a private key x; computing a public key gx mod p by raising said generator g to the power of said private key x, using arithmetic modulo said prime field size p; sending said public key gx mod p to a correspondent; receiving, from the correspondent, a second public key B comprising g raised to a second private key y selected by the correspondent, in the form gy; and creating a key Bx from the received second public key B, by raising said second public key B to the power of said private key x, using arithmetic modulo said prime field size p.

Abstract: A photoresist or semiconductor manufacturing residue stripping and cleaning composition comprising water, one or more alkaline compounds, one or more corrosion inhibitors, and one or more oxidized products of one or more antioxidants, the method of making the composition and the method of using the composition.

Abstract: The present invention provides filter assemblies, tuning elements and a method of tuning a filter. A filter assembly includes a housing having a top cover, a bottom cover and at least one sidewall, the top cover, the bottom cover and the at least one sidewall defining an internal cavity, the housing configured to receive first through third radio frequency (“RF”) transmission lines; a top metal sheet mounted within the internal cavity that has a plurality of openings that form a first hole pattern; and a bottom metal sheet mounted within the internal cavity that has a plurality of openings that form a second hole pattern. The top and bottom metal sheets are vertically spaced-apart from each other in a vertically stacked relationship within the internal cavity. The top metal sheet and the bottom metal sheet each include at least one resonator.

Abstract: A request for a parking space is received from a requesting vehicle. Data is received from at least one data-collecting vehicle related to at least one parking space. Based at least in part on the received data, a parking availability map is generated indicating a parking space appropriate for the requesting vehicle. If the parking space is occupied by an unauthorized vehicle, a message is provided to a parking enforcement authority that the parking space is occupied by an unauthorized vehicle.