Patents by Inventor Richard C. Siegel

Richard C. Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIVIRAL COMPOUNDS
    Publication number: 20240174704
    Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
    Type: Application
    Filed: July 18, 2023
    Publication date: May 30, 2024
    Inventors: Gregory F. Chin, Byoung-Kwon Chun, Michael O. Clarke, Bindu Goyal, Hon C. Hui, Petr Jansa, Richard L. Mackman, Dustin S. Siegel, Hai Yang
  • CD73 compounds
    Patent number: 11919869
    Abstract: Provided herein is A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.
    Type: Grant
    Filed: October 27, 2022
    Date of Patent: March 5, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark J. Bartlett, Gregory F. Chin, Michael O. Clarke, Jennifer L Cosman, Deeba Ensan, Bindu Goyal, Stephen Ho, Richard L Mackman, Michael R. Mish, Dustin S. Siegel, Kyle C. Tamshen, Hai Yang
  • Use of a clathrate modifier, to promote passage of proteins during nanofiltration
    Patent number: 6773600
    Abstract: The invention relates to the field of protein purification and the recovery of large proteinaceous material through small, nanometer sized, pore exclusion filters for removal of contaminants such as viral pathogens.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: August 10, 2004
    Assignee: Cantocor, Inc.
    Inventors: Barry P. Rosenblatt, Richard C. Siegel
  • Use of a clathrate modifier, to promote passage of proteins during nanofiltration
    Publication number: 20030230532
    Abstract: The invention relates to the field of protein purification and the recovery of large proteinaceous material through small, nanometer sized, pore exclusion filters for removal of contaminants such as viral pathogens.
    Type: Application
    Filed: June 4, 2003
    Publication date: December 18, 2003
    Inventors: Barry P. Rosenblatt, Richard C. Siegel
  • Antibody-metal ion complexes
    Patent number: 4741900
    Abstract: This invention relates to antibody-metal ion complexes having a metal ion coordinately bound to a compatible chelator covalently bound to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody-metal ion complexes. Therapeutic and in vitro and in vivo diagnostic methods utilizing such antibody-metal ion complexes are described.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: May 3, 1988
    Assignee: Cytogen Corporation
    Inventors: Vernon L. Alvarez, John D. Rodwell, Chyi Lee, John W. F. Goers, Richard C. Siegel, Thomas J. McKearn
  • Hydrophilic assay reagent containing one member of specific binding pair
    Patent number: 4713350
    Abstract: This invention provides a hydrophilic specific binding assay reagent which is prepared by a process comprising the steps of reacting a partner of a specific binding pair and at least one hydrophilic substance with haloalkyl moieties associated with the surface of a solid phase and recovering the reagent so prepared from any unreacted binding partner. Preferably, the alpha-haloalkyl is chloromethyl and the at least one hydrophilic substance comprises at least one protein, such as albumin, and at least one non-proteinaceous amine to which the solid phase is impermeable, such as tris (hydroxymethyl) aminomethane. The specific binding assay reagent of the invention can be combined with other reagents to provide an assay composition.
    Type: Grant
    Filed: October 24, 1983
    Date of Patent: December 15, 1987
    Assignee: Technicon Instruments Corporation
    Inventors: Richard C. Siegel, Christina S. Marx, Bartholomew Hargitay, Neil Wotherspoon
  • Protected binding assay avoiding non-specific protein interference
    Patent number: 4650751
    Abstract: A specific binding enzyme-resistant ligand assay test material, which material comprises (a) a solid phase incorporated with one partner of a specific binding pair comprising said ligand or a binding analog thereof and a specific binding protein therefor; (b) a conjugate comprising the other partner of said specific binding pair incorporated with a substance which protects the specific binding protein of said pair from enzyme inactivation when bound with its partner; and (c) an active protein-inactivating enzyme. Also a specific binding method of assaying for an enzyme-resistant ligand in a sample, which method uses the above test material and which results in a reduction in interference caused by non-specific protein.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: March 17, 1987
    Assignee: Technicon Instruments Corporation
    Inventors: Richard C. Siegel, Christina S. Marx