Abstract: Various devices and methods for improving intravascular imaging are disclosed. In one embodiment, fluid dispersion devices are included on a catheter to improve dispersal of a flush solution within a flow of fluid (e.g., blood) in a vessel. In other embodiments, a catheter includes at least one inflatable balloon to selectively partially occlude a vessel to be imaged and/or treated in order to minimize the refractory effects of blood on the imaging/treatment process. In one embodiment, a catheter may image/treat at least a portion of a vessel by moving an imaging/treatment device in a distal direction relative to a proximal section of the catheter.