Patents by Inventor Richard Calvin Ebersole

Richard Calvin Ebersole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amplification of assay reporters by nucleic acid replication
    Patent number: 5985548
    Abstract: A method for the amplified detection of an analyte, wherein amplification is achieved by replication of a target nucleic acid sequence which has been immobilized in response to analyte.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: November 16, 1999
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: David Nash Collier, Richard Calvin Ebersole, Tina Marie Hatfield, Edwin R. Hendrickson, John Richard Moran
  • Analyte detection by means of an analyte-responsive polymer
    Patent number: 5756279
    Abstract: A method is provided for detecting an analyte in a liquid sample, the method using light energy propagational properties of an analyte-responsive polymer. The analyte-responsive polymer is interfaced with a means to detect changes in the light propagation of the analyte-responsive polymer and the changes are correlated to the amount of analyte in the liquid sample.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: May 26, 1998
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Richard Calvin Ebersole, Robert Paul Foss, Michael David Ward
  • Analyte detection by means of an analyte-responsive polymer
    Patent number: 5695925
    Abstract: A composition is provided which is a transducing polymer having from 1 to 20 crosslinks per polymer molecule and selected from the group consisting of amphoteric co- or ter-polymers of pI between 6.2 to 8.0 of acrylic acid, alkyl methacrylate, and N,N-dimethly-aminoethyl methacrylate, the amphoteric co- or ter-polymer immobilized on a surface. Also provided is a method for the preparation of an analyte-responsive polymer immobilized on a surface in which the steps are a. mixing a solution of a crosslinker and the claimed transducing polymer, b. applying the solution of step a to a surface, and c. then curing the polymer to a ratio of from 1 to 20 crosslinks per transducing polymer molecule. Acoustic and optical methods for detecting analtyes are also provided which use an analyte-responsive polymer.
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: December 9, 1997
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Richard Calvin Ebersole, Robert Paul Foss, Michael David Ward
  • Assay method for biological target complexes on the surface of a biosensor
    Patent number: 5658732
    Abstract: A biosensor detector method for detecting biological targets, using specific binding, or hybridization techniques coupled with enzymatic amplification and the mass sensing capability of a piezoelectric oscillator. An optical biosensor is also contemplated.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: August 19, 1997
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Richard Calvin Ebersole, John Richard Moran, Michael David Ward