Patents by Inventor Richard Charles Hartley

Richard Charles Hartley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mitochondria-targeted dicarbonyl sequestering compounds
    Patent number: 9963474
    Abstract: The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycemic diabetes. A mass spectrometry probe and to a method of labelling a biological molecule 1 for mass spectrometry detection are also described.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: May 8, 2018
    Assignee: Medical Research Council
    Inventors: Michael Patrick Murphy, Robin Andrew James Smith, Richard Charles Hartley
  • MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS
    Publication number: 20160289252
    Abstract: The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycemic diabetes. A mass spectrometry probe and to a method of labelling a biological molecule 1 for mass spectrometry detection are also described.
    Type: Application
    Filed: November 21, 2014
    Publication date: October 6, 2016
    Inventors: Michael Patrick MURPHY, Robin Andrew James SMITH, Richard Charles HARTLEY
  • Compound
    Patent number: 9359323
    Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: June 7, 2016
    Inventors: Donald Barton McPhail, Graeme James Cook, Richard Charles Hartley
  • Compound
    Publication number: 20130267586
    Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.
    Type: Application
    Filed: October 13, 2011
    Publication date: October 10, 2013
    Applicant: ANTOXIS LIMITED
    Inventors: Donald Barton McPhail, Graeme James Cook, Richard Charles Hartley
  • Flavonoid compounds as therapeutic antioxidants
    Patent number: 7601754
    Abstract: Novel flavonoid compounds having anti-oxidant activity are described. Formula 1. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidative damage, especially curative or prophylactic treatment of Alzheimer's disease or ischaemia-reperfusion injury, is described.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: October 13, 2009
    Assignee: Antoxis Limited
    Inventors: Stuart Thomas Caldwell, Christopher James Bennett, Richard Charles Hartley, Donald Barton McPhail, Garry Graeme Duthie