Abstract: The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g., AMI, with a combination of a tissue plasminogen activator (t-PA) variant having improved fibrin specificity and extended plasma half-life when compared with wild-type human t-PA and a low molecular weight heparin.

Abstract: The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g. AMI, with a combination of a tissue plasminogen activator (t-PA) variant having improved fibrin specificity and extended plasma half-life when compared with wild-type human t-PA and a low molecular weight heparin.

Abstract: A delay locked loop (DLL) circuit and method for testing the operability of the circuit utilizes one or more test signal sources and a test signal receiver to selectively transmit test signals, for example, static test signals, through an array of delay elements of the DLL circuit. The resulting output signals of the array are used to determine whether any delay element or a tap selector of the DLL circuit has malfunctioned, e.g., stuck-at fault.

Abstract: A delay locked loop (DLL) circuit and method for testing the operability of the circuit utilizes one or more test signal sources and a test signal receiver to selectively transmit test signals, for example, static test signals, through an array of delay elements of the DLL circuit. The resulting output signals of the array are used to determine whether any delay element or a tap selector of the DLL circuit has malfunctioned, e.g., stuck-at fault.

Abstract: A reclosable lid (10) for a container holding a flowable substance has a cover (12) having an opening (28) and a moveable element (850) connected to the cover (12). The moveable element (850) is moveable between at least one open position, wherein the flowable substance may flow through the opening, and at least one closed position, wherein the opening is obstructed. In some embodiments, the lid (10) may include an overlay (250) moveable between at least one open position and at least one closed position.

Abstract: A system for selectively affecting data flow to and/or from a memory device. The system includes a first mechanism for intercepting data bound for the memory device or originating from the memory device. A second mechanism compares a data level associated with the first mechanism to one or more thresholds and provides a signal in response thereto. A third mechanism selectively releases data from the first mechanism or from the memory device in response to the signal. In the specific embodiment, the first mechanism includes one or more First-In-First-Out (FIFO) memory buffers having level indicators that provide data level information. The third mechanism includes a memory manager that provides the signal to the one or more FIFO buffers or to the memory device based on the data level information, thereby causing the one or more FIFO buffers to release the data or accept data from the memory device.

Abstract: A system and method for stabilizing the temperature of a detector array. The novel invention (100) includes one or more video reference pixels (52) adapted to output a reference signal that is responsive to the temperature of the detector array (50), and a mechanism for adjusting the temperature of the detector array (50) based on the reference signal. In the illustrative embodiment, the mechanism includes a thermal electric cooler (112) and a processor (104) running a control algorithm (106) which calculates the amount of current which should be applied to the thermal electric cooler (112) based on the reference signal from the video reference pixels (52). The video reference pixels (52) are constructed from the same substrate as the detector array (50), but are constructed in a manner such that they do not respond to changes in scene illumination.

Abstract: A system and method for aligning an input signal (24) synchronized to a first clock signal (22) with a second clock signal (26). The invention includes a mechanism (106) for generating a third clock signal (354) and an arrangement (352) for loading the input signal (24) in accordance with the third clock signal (354) and reading out an output signal in accordance with the second clock signal (26). In an illustrative embodiment, the invention is used in a sensor system (350) to align detector input data (24), which is synchronized to a data-capture clock (22), with a signal-processing clock (26). The register (352) acts as a data path transitioning stage between the actual time the input data is sampled and the time a processing system (102) clocks in the sampled data.

Abstract: An orthopedic implantable device articulately connecting a first spinal vertebra to an adjacent second spinal vertebra includes a pair of first components adapted to be attached to locations left and right of a midline of the first vertebra, respectively; and a pair of second components adapted to be attached to locations left and right of a midline of the second vertebra, respectively. Each of the first components includes a body and a male articulation member attached to the first component body and each of the second components includes a body and a female articulation member attached to the second component body. The first components are articulately connected to the second components by engaging the male articulation members to the female articulation members, thereby articulately connecting the first vertebra to said second vertebra along lines left and right of the midlines, respectively.

Abstract: The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g. AMI, with a combination of a tissue plasminogen activator (t-PA) variant having improved fibrin specificity and extended plasma half-life when compared with wild-type human t-PA and a low molecular weight heparin.

Abstract: An orthopedic implantable device articulately connects a first spinal vertebra to an adjacent second spinal vertebra along the midline of the first and second vertebrae or along an axis medial to the facets. The device includes a first component having a male articulation member and a second component having a female articulation member. The first and second components are adapted to be attached to posterior locations of the first and the second vertebrae, respectively. The first component is articulately connected to the second component by engaging the male articulation member to the female articulation member or vice versa. The articulation mechanisms may be a hook and loop or a hinge. First and second components are configured to replace the natural lamina, spinous process, pars interarticularis, and/or facets of the corresponding first and second vertebrae.

Abstract: A spine fixation assembly connecting a first and second vertebra includes first and second elongated plates that form an X-shaped structure. The first elongated plate has a first and a second end that are attached to a first location of the first vertebra and to a second location of the second vertebra, respectively. The second elongated plate has a first and a second end that are attached to a second location of said first vertebra and to a first location of the second vertebra, respectively. The ends of the plates are attached to the various locations of the vertebra via screws or hooks. The elongated plates may have adjustable length, may be rotated around a central axis passing through the center of-the X-shaped structure and may be cross-coupled to each other via a screw. A third and fourth elongated plated may be attached horizontally across the top and bottom of the X-shaped structure, respectively.

Abstract: An orthopedic implantable device articulately connects a first spinal vertebra to an adjacent second spinal vertebra along the midline of the first and second vertebrae or along an axis medial to the facets. The device includes a first component having a male articulation member and a second component having a female articulation member. The first and second components are adapted to be attached to posterior locations of the first and the second vertebrae, respectively. The first component is articulately connected to the second component by engaging the male articulation member to the female articulation member or vice versa. The articulation mechanisms may be a hook and loop or a hinge. First and second components are configured to replace the natural lamina, spinous process, pars interarticularis, and/or facets of the corresponding first and second vertebrae.

Abstract: A spine fixation assembly connecting a first and second vertebra includes first and second elongated plates that form an X-shaped structure. The first elongated plate has a first and a second end that are attached to a first location of the first vertebra and to a second location of the second vertebra, respectively. The second elongated plate has a first and a second end that are attached to a second location of said first vertebra and to a first location of the second vertebra, respectively. The ends of the plates are attached to the various locations of the vertebra via screws or hooks. The elongated plates may have adjustable length, may be rotated around a central axis passing through the center of the X-shaped structure and may be cross-coupled to each other via a screw. A third and fourth elongated plated may be attached horizontally across the top and bottom of the X-shaped structure, respectively.

Abstract: A function for adaptively generating test vectors to verify the behavior of a digital system. The function utilizes one or more user-defined verification directives for directing the generation of the test vectors to areas of interest within the digital system. An emulator of the digital system provides dynamic feedback of internal state information to the test vector generation function during the verification. The test vector generation function adaptively generates future verification test vectors based on the user-defined verification directives in view of the internal state information feedback received from the emulator.

Abstract: A function for verifying the behavior of a digital system, where the digital system can exhibit several differing but valid behaviors from the same input. Identical input vectors are applied to both a hardware model and hardware emulator of the digital system via a simulator. Simulating the hardware emulator generates one or more predicted output vectors, while simulating the hardware model produces a single output vector. The output vector of the hardware model is then compared with the one or more predicted output vectors of the hardware emulator. If there is not an output match, an exception is raised. If the output vector of the hardware model matches one of the predicted output vectors of the hardware emulator, a rules checker applies a set of context specific rules defining a valid behavior to the current matching output vector, the internal model state information from the hardware emulator, and a history file of previous output vectors.

Abstract: An engine comprises a rotary unit (1) and a reciprocating unit (3) coupled to a common drive (7). A first rotary unit (1) provides the induction phase of the 4-stroke cycle and passes air to the reciprocating unit for the compression and combustion phases. The exhaust gases are passed to a second rotary unit (5) having an afterburner for the exhaust phase. Alternatively, two rotary units and two reciprocating units each having two pistons may be arranged alternately. The invention may also be utilized for improved 2-stroke engines making one power pulse per stroke.

Abstract: A thermal infrared imaging device (10) includes a thermal detector (50) having a linearly-arrayed plurality of spaced apart detector elements (50', 50", 50"', . . . ). A scene to be viewed is scanned across the detector (50) with successive fields of the scene shifted according the spacing between adjacent detector elements (50', 50", 50"', . . . ) in order to capture image information for the entire scene by interlacing of successive scan lines from the plurality of detector elements (50', 50", 50"', . . . ). Each complete scan of the viewed scene across the detector (50) creates an image field including a scan line for each detector element (50', 50", 50"', . . . ). Each scan line includes plural pixels, or picture elements of the viewed scene, each having a value indicative of the thermal infrared brightness of the viewed scene at the corresponding location along the scan line. An scan-line sum for each scan line is created by adding the absolute values of the pixel values for each scan line.

Abstract: A thermal imaging device (10) provides for its use with a variety of accessory telescopic lenses (12). Each of the accessory telescopic lenses (12) and the thermal imaging device (10) include cooperating physical features allowing the lenses (12) to be mated with the device (10) in a single relative position. Each lens (12) also carries a uniquely positioned magnet (176), and the thermal imaging device (10) includes a plurality of magnetically-responsive sensors (178) responding to the magnets (176) of the various lenses (12) to identify which (if any) of the accessory lens (12) is installed on the device (10). Some of the accessory lenses (12) also include a variable-power feature. These variable-power lenses (12) have an additional magnet (182) moving between an effective position and an ineffective position in response to a user-selected power setting for the lens (12).

Abstract: A thermal imaging device (10) has single integrated circuit chip (86) to perform various analog signal processing (ASP) functions. The imaging device (10) has a detector array (50) including a plurality of detectors (50') each of which generate an electrical signal (78) indicative of the infrared flux incident thereon. These electrical signals (78) are processed and provided in the form of serial analog video signals (52) to the ASP chip (86). The ASP chip (86) includes circuitry (200) for correcting for the differing responsivity of serial manufactured detector arrays (50), circuitry (202) for correcting the gain of the serial analog signal (52) globally, and circuitry (206) for sensing the gain of a processing serial analog signal (90) which the ASP chip (86) provides to an analog-to-digital (A/D) converter (92) of the thermal imaging device (10).