Publication number: 20070072897
Abstract: The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.
Type:
Application
Filed:
September 27, 2006
Publication date:
March 29, 2007
Applicant:
Wyeth
Inventors:
Paige Mahaney, Gavin Heffernan, Richard Coghlan, Stephen Cohn, Callain Kim, Douglas Jenkins, Michael Marella, Casey McComas, Joseph Sabatucci, Eugene Terefenko, Eugene Trybulski, An Vu, Fei Ye, Puwen Zhang