Patents by Inventor Richard D. Abramson

Richard D. Abramson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5' to 3' exonuclease mutations of thermostable DNA polymerases
    Patent number: 5795762
    Abstract: The present invention relates to thermostable DNA polymerases which exhibit a different level of 5' to 3' exonuclease activity than their respective native polymerases. Particular conserved amino acid domains in thermostable DNA polymerases are mutated or deleted to alter the 5' to 3' exonuclease activity of the polymerases. The present invention also relates to means for isolating and producing such altered polymerases.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 18, 1998
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Richard D. Abramson, David H. Gelfand
  • DNA encoding thermostable nucleic acid polymerase enzyme from thermus species Z05
    Patent number: 5674738
    Abstract: A purified thermostable enzyme is derived from the eubacterium Thermus species Z05. The enzyme has DNA polymerase, activity reverse transcriptase activity, and optionally 5'.fwdarw.3' exonuclease activity. The enzyme can be native or recombinant, and may be used with primers and nucleoside triphosphates in a temperature-cycling chain reaction where at least one nucleic acid sequence is amplified in quantity from an existing sequence.
    Type: Grant
    Filed: August 29, 1995
    Date of Patent: October 7, 1997
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Richard D. Abramson, David H. Gelfand, I. Lawrence Greenfield
  • 5' to 3' exonuclease mutations of thermostable DNA polymerases
    Patent number: 5466591
    Abstract: The present invention relates to thermostable DNA polymerases which have been mutated such that a lesser amount of 5' to 3' exonuclease activity is exhibited from that which is exhibited by the native enzyme.
    Type: Grant
    Filed: February 23, 1993
    Date of Patent: November 14, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard D. Abramson, David H. Gelfand
  • Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05
    Patent number: 5455170
    Abstract: A purified thermostable enzyme is derived from the eubacterium Thermus species Z05. The enzyme has DNA polymerase, activity reverse transcriptase activity, and optionally 5'.fwdarw.3' exonuclease activity. The enzyme can be native or recombinant, and may be used with primers and nucleoside triphosphates in a temperature-cycling chain reaction where at least one nucleic acid sequence is amplified in quantity from an existing sequence.
    Type: Grant
    Filed: August 27, 1993
    Date of Patent: October 3, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard D. Abramson, David H. Gelfand, I. Lawrence Greenfield
  • DNA encoding a mutated thermostable nucleic acid polymerase enzyme from thermus species sps17
    Patent number: 5405774
    Abstract: A purified thermostable enzyme is derived from the bacterium Thermus species sps17. The enzyme has DNA polymerase activity, reverse transcriptase activity, and optionally, 5'.fwdarw.3' exonuclease activity. The enzyme can be native or recombinant, and can be used with selected primers and nucleoside triphosphates in a temperature-cycling chain reaction where at least one nucleic acid sequence is amplified in quantity from an existing sequence.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: April 11, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard D. Abramson, David H. Gelfand, I. Lawrence Greenfield