Patents by Inventor Richard D. Gless

Richard D. Gless has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBIOTIC OLIGOPEPTIDE MIMETICS
    Publication number: 20180340008
    Abstract: Disclosed are amino acid mimetics that possess antibiotic properties in prokaryotic cells. These mimetics are coupled to one or more optionally substituted amino acids provided that at least one of the amino acids is an optionally substituted amino acid selected from the group consisting of phenylglycine, tryptophan, phenylalanine, histidine, and tyrosine.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventors: Mansour BASSIRI, Richard D. GLESS
  • ANTIBIOTIC OLIGOPEPTIDES
    Publication number: 20180298053
    Abstract: Disclosed are methionine mimetics that possess antibiotic properties in prokaryotic cells. These mimetics are coupled to one or more optionally substituted amino acids provided that at least one of the amino acids is phenylglycine, tryptophan, phenylalanine or tyrosine.
    Type: Application
    Filed: April 17, 2018
    Publication date: October 18, 2018
    Inventors: Mansour BASSIRI, Richard D. GLESS
  • ANTIBIOTIC AMINO ACID MIMETICS
    Publication number: 20180282271
    Abstract: Disclosed are methionine mimetic compounds that possess antibiotic properties in prokaryotic cells. The compounds of this invention comprise a dipeptide having a methionine mimetic bound to an aromatic amino acid. Such compounds exhibit significantly improved antibacterial properties.
    Type: Application
    Filed: March 26, 2018
    Publication date: October 4, 2018
    Inventors: Mansour BASSIRI, Richard D. Gless
  • Substituted noribogaine
    Patent number: 9783535
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: October 10, 2017
    Inventors: Deborah C. Mash, Richard D. Gless, Robert M. Moriarty
  • Noribogaine salt ansolvates
    Patent number: 9617265
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Grant
    Filed: May 23, 2015
    Date of Patent: April 11, 2017
    Assignee: DEMERX, INC.
    Inventors: Richard D. Gless, Jr., William C. Schinzer
  • Synthetic noribogaine
    Patent number: 9617274
    Abstract: Synthetic noribogaine preferably free of ibogaine and, optionally, one or more of other naturally occurring Tabernanth iboga alkaloids, is provided.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: April 11, 2017
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Richard D. Gless, Jr.
  • STABLE CRYSTALLINE NORIBOGAINE SALT ANSOLVATES
    Publication number: 20170022194
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicant: DemeRx, Inc.
    Inventors: Richard D. Gless, JR., William C. Schinzer
  • NORIBOGAINE SALT TABLETS
    Publication number: 20170022193
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicant: DemeRx, Inc.
    Inventors: Richard D. Gless, JR., William C. Schinzer
  • Methods and compositions for preparing noribogaine from voacangine
    Patent number: 9403817
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: August 2, 2016
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, Jr.
  • Methods and compositions for preparing and purifying noribogaine
    Patent number: 9394294
    Abstract: Disclosed are methods and compositions for purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: July 19, 2016
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr.
  • PHOSPHATE ESTERS OF NORIBOGAINE
    Publication number: 20160115185
    Abstract: Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the methods of their use, including in the treatment of addiction and/or pain.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 28, 2016
    Applicant: DEMERX, INC.
    Inventors: Richard D. Gless, JR., Robert M. Moriarty
  • NORIBOGAINE SALT ANSOLVATES
    Publication number: 20160108043
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Application
    Filed: May 23, 2015
    Publication date: April 21, 2016
    Applicant: DEMERX, INC.
    Inventors: Richard D. Gless, JR., William C. Schinzer
  • Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
    Patent number: 9308272
    Abstract: This invention relates generally to compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: April 12, 2016
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Richard D. Gless
  • SUBSTITUTED NORIBOGAINE
    Publication number: 20150361080
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Application
    Filed: May 21, 2015
    Publication date: December 17, 2015
    Applicant: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, JR., Robert M. Moriarty
  • SUBSTITUTED NORIBOGAINE
    Publication number: 20150329536
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Application
    Filed: December 20, 2012
    Publication date: November 19, 2015
    Inventors: Deborah C. Mash, Richard D. Gless, Robert M. Moriarty
  • Phosphate esters of noribogaine
    Patent number: 9051343
    Abstract: Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the methods of their use, including in the treatment of addiction and/or pain.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: June 9, 2015
    Assignee: DEMERX, INC.
    Inventors: Richard D. Gless, Jr., Robert M. Moriarty
  • Substituted noribogaine
    Patent number: 9045481
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: June 2, 2015
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr., Robert M. Moriarty
  • Noribogaine salt ansolvates
    Patent number: 9040520
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 26, 2015
    Assignee: DemeRx, Inc.
    Inventors: Richard D. Gless, Jr., William C. Schinzer
  • METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE
    Publication number: 20150133655
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Application
    Filed: October 14, 2014
    Publication date: May 14, 2015
    Applicant: DEMERX, INC.
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, JR.
  • Substituted noribogaine
    Patent number: 8940728
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: January 27, 2015
    Assignee: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr., Robert M. Moriarty