Abstract: Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.

Abstract: Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.

Abstract: Methods include directing a group of ions through a separation region of an ion manipulation apparatus, separating the group of ions in the separation region based on ion mobility, selecting a subset of the group of ions based on a dependence between ion mobility and ion arrival time of the separated ions at a deposition switch of the ion manipulation apparatus, and depositing the selected subset of ions on a substrate. Related systems and ion manipulation apparatus are disclosed. Also disclosed are methods and system that provide concurrent ion accumulation and ion separation in coupled and switchable electrode regions using traveling wave electric fields.

Abstract: The present disclosure provides for compositions and methods of treating cancer. In some embodiments, PTPN11 is targeted with and anti-PTPN11 drug, such as a Shp2 inhibitor (e.g., SHP099). In some embodiments, other upregulated, hyperphosphorylated, or hyperacetylated target proteins are inhibited or targeted.

Abstract: A chair comprises a seat and a backrest carried between opposite frame sides each with a backrest support, a front leg and a rear leg. The seat comprises an upholstered seat cushion disposed on the seat. The upholstered seat cushion comprising a cushion layer carried by a backing and covered by a layer of upholstery. The layer of upholstery extends over the cushion layer and the backing, and wraps around a perimeter of the backing. A snap connection attaches the backing of the upholstered seat cushion to the seat. The snap connection comprises resilient hooks extending from backing of the seat cushion and into holes in the seat.

Abstract: Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.

Abstract: A carrying case for a portable electronic device includes an adjustable viewing stand for supporting the electronic device at an angle selected by the user, the adjustable viewing stand comprising at least two panels hingably connected to one another and foldable so as to be able to reside inside the carrying case when the carrying case is closed and the carrying case comprising at least one subwell.

Abstract: Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities. A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.

Abstract: A chair comprises a seat and a backrest carried between opposite frame sides each with a backrest support, a front leg and a rear leg. The seat comprises an upholstered seat cushion disposed on the seat. The upholstered seat cushion comprising a cushion layer carried by a backing and covered by a layer of upholstery. The layer of upholstery extends over the cushion layer and the backing, and wraps around a perimeter of the backing. A snap connection attaches the backing of the upholstered seat cushion to the seat. The snap connection comprises resilient hooks extending from backing of the seat cushion and into holes in the seat.

Abstract: A processor of a device may provision a component of the device with a digital signature algorithm and an authentication key algorithm and/or server-provisioned private and/or public keys. The processor may generate one or more private keys and public keys and/or store them in a secure memory of the device. The processor may transmit the generated public keys to an owner server and receive a pedigree document in response, which may be signed with the private key. The owner server may determine a change in an ownership of the device and append the pedigree document in an immutable fashion in response to the determining to reflect the change in the ownership and/or sign the appended pedigree document with a private key. A chain of ownership of the device is verifiable using only information contained within the appended pedigree document and rooted in the processor itself.

Abstract: A welding helmet can record a welding time based on an arc intensity detected by a sensor mounted on the helmet. A configured level is compared with the arc intensity detected by the sensor to determine a welding duration. Individual welding times from multiple welding instances can be accumulated over a period of time to provide a total welding time for an operator. The total welding time may be stored in the welding helmet.

Abstract: A switch for coupling a first ion manipulation device to a second ion manipulation device comprises a first surface and a second surface, at least one first electrode coupled to each of the first and second surface and configured to receive a first voltage and generate a first potential, and at least one second electrode coupled to each of the first and second surface and configured to receive a second voltage and generate a second potential, wherein the first potential inhibits the motion of ions along a first direction and the second potential inhibits the motion of ions along a second direction different from the first direction.

Abstract: Apparatus include a plurality of electrode arrangements spaced apart from each other opposite an ion propagation axis and defining an ion transfer channel that extends along the ion propagation axis that tapers between an input end that is situated to receive ions and an output end that is situated to couple the received ions to an input end of an ion guide. Methods include positioning a plurality of electrode arrangements at oblique angles opposite an ion propagation axis so as to form a ion transfer channel that tapers between an input end and an output end, and coupling the output end of the ion transfer channel to an input end of an ion optical element so as to direct ions in the ion transfer channel into the ion optical element. Related systems are also disclosed.

Abstract: A carrying case for a portable electronic device includes an adjustable viewing stand for supporting the electronic device at an angle selected by the user, the adjustable viewing stand comprising at least two panels hingably connected to one another and foldable so as to be able to reside inside the carrying case when the carrying case is closed and the carrying case comprising at least one subwell.

Abstract: A carrying case for a portable electronic device includes an adjustable viewing stand for supporting the electronic device at an angle selected by the user, the adjustable viewing stand comprising at least two panels hingably connected to one another and foldable so as to be able to reside inside the carrying case when the carrying case is closed.

Abstract: A carrying case for a portable electronic device includes an adjustable viewing stand for supporting the electronic device at an angle selected by the user, the adjustable viewing stand comprising at least two panels hingably connected to one another and foldable so as to be able to reside inside the carrying case when the carrying case is closed.

Abstract: Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities. A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.

Abstract: An apparatus includes a first pair of opposing electrode arrangements that confine ions between them in a portion of a confinement volume inwardly laterally in a first confinement direction with respect to a longitudinal ion propagation direction, each opposing electrode arrangement including an arrangement of RF electrodes situated to receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes of the arrangement of RF electrodes so as to provide the confining of ions between the first pair of opposing electrode arrangements, and a second pair of opposing electrode arrangements that confine the ions between the second pair in the confinement volume inwardly laterally in a second confinement direction that complements the first confinement direction, each opposing electrode arrangement of the second pair including an arrangement of RF electrodes that receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes.