Abstract: An apparatus and method for supplemental oxygen administration to a patient that provides enhanced efficiency of oxygen use due to the administration of an oxygen bolus at the beginning of each inhalation by a patient. The supplemental oxygen delivery device utilizes first and second one-way valves corresponding to air inspiration and air expiration ports, respectively, and that are positioned in an air pathway so that air inspiration opens the first one-way valve to permit air flow through the air inspiration port and air expiration closes the first one-way valve and opens the second one-way valve to permit air expiration through the air expiration port. An oxygen supply source is connected to the device so as to provide an air bolus in the air pathway upstream and in front of the first one-way valve so as to provide a burst of oxygen during the first part of inhalation.

Abstract: This invention relates to a method for improving the resistance of biomaterial to thrombosis and infection and for improving tissue ingrowth, by eliminating undissolved gasses therefrom and by incorporation of therapeutic agents therein via the application of hydrostatic pressure.