Abstract: The present invention relates to methods of treating disorders in which DOT1L-mediated protein methylation plays a part, such as cancer, by administering DOT1L inhibitor compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: Blasting apparatus are disclosed relating to abrasive blasting that include a blasting pot and a blast pot discharge assembly connected to the blasting pot below the blasting pot. The blast pot discharge assembly may contain an elbow section and an eccentric reducer section and may also have an injector in the elbow section that injects liquid into the elbow section toward the eccentric reducer section.

Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase DOT1L and one or more therapeutic agents, particularly anticancer agents, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.

Abstract: Use of Sulfurihydrogenibium sp. carbonic anhydrase (SspCA) or mutants thereof for catalyzing the hydration reaction of CO2 into bicarbonate and hydrogen ions or catalyzing the desorption reaction to produce a CO2 gas is provided.

Abstract: The present invention relates to methods of treating disorders in which DOT1L-mediated protein methylation plays a part, such as cancer, by administering DOT1L inhibitor compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to polynucleotide and polypeptide sequences of novel carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase.

Abstract: The present invention relates to polynucleotide and polypeptide sequences of novel carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase.

Abstract: The present invention relates to polynucleotide and polypeptide sequences of novel carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase.

Abstract: The present invention relates to polynucleotide and polypeptide sequences of carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase.

Abstract: Disclosed is a pallet loading and unloading sling, termed a SlingBag device, for efficiently transporting burlap bags and deploying them to secure and protect underwater pipelines. In preferred form, the SlingBag is a T-shaped mat that folds up into a four-sided bag. By using a SlingBag atop a wooden pallet, the process for loading and unloading burlap bags from the pallet may be simplified The SlingBag comprises two rectangular mats that are arranged in a perpendicular cross section, forming a T-shaped mat. When placed upon a pallet for loading, the central panel fits atop the pallet, and the four side flaps extend outward. Burlap bags filled with dry bulk sand or dry sand/cement mix are stacked atop the pallet with the SlingBag. Then, the side flaps are folded up to form a four-sided sling container, and the lifting loops on the side panels are tied in place to secure the sling. In the preferred embodiment, the SlingBag is comprised of polypropylene.

Abstract: Disclosed is a pallet loading and unloading sling, termed a SlingBag device, for efficiently transporting burlap bags and deploying them to secure and protect underwater pipelines. In preferred form, the SlingBag is a T-shaped mat that folds up into a four-sided bag. By using a SlingBag atop a wooden pallet, the process for loading and unloading burlap bags from the pallet may be simplified The SlingBag comprises two rectangular mats that are arranged in a perpendicular cross section, forming a T-shaped mat. When placed upon a pallet for loading, the central panel fits atop the pallet, and the four side flaps extend outward. Burlap bags filled with dry bulk sand or dry sand/cement mix are stacked atop the pallet with the SlingBag. Then, the side flaps are folded up to form a four-sided sling container, and the lifting loops on the side panels are tied in place to secure the sling. In the preferred embodiment, the SlingBag is comprised of polypropylene.

Abstract: Disclosed is a pallet loading and unloading sling, termed a SlingBag device, for efficiently transporting burlap bags and deploying them to secure and protect underwater pipelines. In preferred form, the SlingBag is a T-shaped mat that folds up into a four-sided bag. By using a SlingBag atop a wooden pallet, the process for loading and unloading burlap bags from the pallet may be simplified The SlingBag comprises two rectangular mats that are arranged in a perpendicular cross section, forming a T-shaped mat. When placed upon a pallet for loading, the central panel fits atop the pallet, and the four side flaps extend outward. Burlap bags filled with dry bulk sand or dry sand/cement mix are stacked atop the pallet with the SlingBag. Then, the side flaps are folded up to form a four-sided sling container, and the lifting loops on the side panels are tied in place to secure the sling. In the preferred embodiment, the SlingBag is comprised of polypropylene.

Abstract: The present invention relates to polynucleotide and polypeptide sequences of novel carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase.

Abstract: Disclosed is an apparatus for pipeline stabilization and shoreline erosion protection, termed a BulkMat device, for protecting and securing pipelines, which are typically located in ditches or on the floor of large bodies of water. In preferred form, the BulkMat comprises a long fabric mat with four to eight fabric compartments sewn onto the mat and filled with dry bulk sand/cement mix. In the preferred embodiment, the BulkMat is comprised of polypropylene. The BulkMat has four lifting loops that are used to pick-up and lower the BulkMat onto the desired location. When the bulk mat is placed on the location, and water sets in, the sand/cement mix in the compartments will harden to concrete. By hardening after it is set in place, the BulkMat will conform completely to the pipeline or covered area to be protected, precisely matching the specific area.

Abstract: Disclosed is a pallet loading and unloading sling, termed a SlingBag device, for efficiently transporting burlap bags and deploying them to secure and protect underwater pipelines. In preferred form, the SlingBag is a T-shaped mat that folds up into a four-sided bag. By using a SlingBag atop a wooden pallet, the process for loading and unloading burlap bags from the pallet may be simplified The SlingBag comprises two rectangular mats that are arranged in a perpendicular cross section, forming a T-shaped mat. When placed upon a pallet for loading, the central panel fits atop the pallet, and the four side flaps extend outward. Burlap bags filled with dry bulk sand or dry sand/cement mix are stacked atop the pallet with the SlingBag. Then, the side flaps are folded up to form a four-sided sling container, and the lifting loops on the side panels are tied in place to secure the sling. In the preferred embodiment, the SlingBag is comprised of polypropylene.

Abstract: Disclosed is an apparatus for pipeline stabilization and shoreline erosion protection, termed a BulkMat device, for protecting and securing pipelines, which are typically located in ditches or on the floor of large bodies of water. In preferred form, the BulkMat comprises a long fabric mat with four to eight fabric compartments sewn onto the mat and filled with dry bulk sand/cement mix. In the preferred embodiment, the BulkMat is comprised of polypropylene. The BulkMat has four lifting loops that are used to pick-up and lower the BulkMat onto the desired location. When the bulk mat is placed on the location, and water sets in, the sand/cement mix in the compartments will harden to concrete. By hardening after it is set in place, the BulkMat will conform completely to the pipeline or covered area to be protected, precisely matching the specific area.

Abstract: An object-based relational distributed database system and associated methods of operation that transforms data stored in a plurality of remote, heterogeneous user databases into a homogeneous data model is disclosed. Data stored in distributed, heterogeneous user database structures is homogenized by mapping into object attributes of predetermined instances of objects forming to a conceptual model that relates the various heterogeneous databases. The object attributes are stored in remote databases at client sites, which can be separate computer systems from the heterogeneous user databases or separate processes running on a computer system that maintains the heterogeneous user databases. The system stores location information and status information relating to the homogenized data in a centralized object broker for object management, thereby facilitating location and retrieval of data items from one or more of the remote, heterogeneous user databases.

Abstract: An object-based relational distributed database system and associated methods of operation that transforms data stored in a plurality of remote, heterogeneous user databases into a homogeneous data model is disclosed. Data stored in distributed, heterogeneous user database structures is homogenized by mapping into object attributes of predetermined instances of objects forming to a conceptual model that relates the various heterogeneous databases. The object attributes are stored in remote databases at client sites, which can be separate computer systems from the heterogeneous user databases or separate processes running on a computer system that maintains the heterogeneous user databases. The system stores location information and status information relating to the homogenized data in a centralized object broker for object management, thereby facilitating location and retrieval of data items from one or more of the remote, heterogeneous user databases.

Abstract: Disclosed is a flooding system for uprighting and setting marine structures into and above bodies of water. The structures include a surface platform and at least one hollow support leg. Each leg includes at least one port that when closed will seal the leg. The system includes a valve attached to each port. The valve serves as a closure that regulates the flow of water from the body of water through the port to flood the structure. An operator is coupled to each valve by a low friction remote control cable. The operator is located above the surface of the body of water and usually attached to the platform. The cable translates the relative motion of the operator to open and close the valve. The cable comprises a flexible member encased in a flexible casing. The flexible member is isolated from the casing by a bearing means that allows the member to move axially within the casing to translate the motion of the operation to control the valve.