Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: The present invention relates to isolated strains of Epichloë endophytes that form symbiotic associations with host plants, wherein the symbiotic associations are combinations of endophytes and host plants that are not found in nature. The invention also relates to combinations of host plants and Epichloë endophytes that are not found in nature, methods of making such combinations and methods of conferring at least some level of pest resistance on a host plant using such endophytes.

Abstract: The present invention relates to isolated strains of Epichloë endophytes that form stable symbiotic associations with cereal grasses, particularly wheat, wherein the symbiotic associations are combinations of endophytes and host plants that are not found in nature The invention also relates to methods of identifying and/or selecting fungal endophytes that form stable symbiotic associations with wheat plants including methods of screening for fungal endophytes that form stable symbiotic associations with wheat plants, and to methods of screening for wheat plants that form stable symbiotic associations with fungal endophytes.

Abstract: The present invention generally relates to methods of producing one or more indole diterpene compounds in the epoxy janthitrem biosynthetic pathway and polynucleotides, polypeptides, expression constructs and host cells useful in the production of one or more indole diterpene compounds, and methods of using same to confer a benefit to an organism, such as increased insect pest resistance.

Abstract: The present invention relates to isolated strains of Epichloë endophytes that form symbiotic associations with host plants, wherein the symbiotic associations are combinations of endophytes and host plants that are not found in nature. The invention also relates to combinations of host plants and Epichloë endophytes that are not found in nature, methods of making such combinations and methods of conferring at least some level of pest resistance on a host plant using such endophytes.

Abstract: The present invention relates to isolated strains of Epichloë endophytes that form stable symbiotic associations with cereal grasses, particularly wheat, wherein the symbiotic associations are combinations of endophytes and host plants that are not found in nature The invention also relates to methods of identifying and/or selecting fungal endophytes that form stable symbiotic associations with wheat plants including methods of screening for fungal endophytes that form stable symbiotic associations with wheat plants, and to methods of screening for wheat plants that form stable symbiotic associations with fungal endophytes.

Abstract: The present invention relates to at least one epichloae fungal endophyte strain combined with at least one species of Secale spp., which confers at least some level of pest protection on the Secale spp. plant. In particular, the invention relates to an isolated strain of epichloae fungal endophyte selected from the group consisting of AR3039 (NRRL# 50716), AR3046 (NRRL# 50576), AR3049 (NRRL#50577), AR3050 (NRRL# 50578), AR3064 (NRRL# 50718), AR3067 (NRRL# 50719), AR3068 (NRRL# 50720), AR3073 (NRRL# 50721), AR3074 (NRRL# 50722), AR3076 (NRRL# 50723), and AR3078 (NRRL# 50724), and combinations thereof; a Secale spp. plant infected with a fungal endophyte wherein Secale spp. is not a natural host of the endophyte; a method of making a stable host plant/epichloae fungal endophyte combination; a method of conferring at least some level of pest protection on a host Secale spp. plant; and a Secale spp. seed infected with an epichloae fungal endophyte.

Abstract: The invention provides a method and compositions for detecting the presence of viable endophyte in a plant, the method comprising germinating seed and excising a young leaf, optionally preparing an extract from the young leaf, and performing antibody, nucleic acid, or preferably PCR-based methods to detect the viable endophyte, wherein at least one primer hybridizes to the intergenic region (IGS) of the ribosomal repeat region of a specific endophyte when used in a PCR-based method. The invention provides a new method for rapid identification of both viable beneficial endophytes and any viable contaminating endophytes, as opposed to any non-viable endophytes, by detecting the presence of endophytes in the first leaf of germinated plants.

Abstract: The present invention relates to at least one epichloae fungal endophyte strain combined with at least one species of Secale spp., which confers at least some level of pest protection on the Secale spp. plant. In particular, the invention relates to an isolated strain of epichloae fungal endophyte selected from the group consisting of AR3039 (NRRL #50716), AR3046 (NRRL #50576), AR3049 (NRRL #50577), AR3050 (NRRL #50578), AR3064 (NRRL #50718), AR3067 (NRRL #50719), AR3068 (NRRL #50720), AR3073 (NRRL #50721), AR3074 (NRRL #50722), AR3076 (NRRL #50723), and AR3078 (NRRL #50724), and combinations thereof; a Secale spp. plant infected with a fungal endophyte wherein Secale spp. is not a natural host of the endophyte; a method of making a stable host plant/epichloae fungal endophyte combination; a method of conferring at least some level of pest protection on a host Secale spp. plant; and a Secale spp. seed infected with an epichloae fungal endophyte.

Abstract: The invention provides a methods and compositions for detecting the presence of viable endophyte in a plant, the method comprising detecting the presence of an endophyte in a young leaf or extract thereof, from the plant, wherein detecting the presence of the endophyte in the young leaf or extract is indicative of the presence of viable endophyte in the plant.

Abstract: Method for logging diagnostic information, for use in a transactional environment having function for sending a transactional and re-sendable request to an application program. A counter is associated with the request, wherein a value associated with the counter is updated when an error occurs in the environment. The environment also comprises a counter threshold. The method utilizes a comparator, responsive to sending the request, for comparing the value associated with the counter against the counter threshold; a tracing control component, responsive to the value associated with the counter meeting the counter threshold, for enabling a tracing program; and a logging component, responsive to re-sending the request, for logging diagnostic information generated by the tracing program.

Abstract: Updated operating code and parameters can be reprogrammed into a modem system with no disassembly of the modem hardware. The modem system includes a memory chip in which operating code and parameters are stored. Two control programs control the reprogramming of updated operating code. One of the control programs is designed for manufacturing and testing purposes. The other control program allows remote reprogramming of updated operating code or parameters from a remote location such as a customer site. A user can thus remotely upgrade system firmware with updates, bug fixes, enhancements or other new releases of system operating code by downloading the update over a phone line to a host PC and reprogramming the memory chip of the modem over the serial port from the host PC. The user can also remotely upgrade the modem system firmware by directly programming the memory chip of the modem without the assistance of the host PC. The modem system is portable, obtaining power from a standard 9 volt battery.

Abstract: Updated opening code and parameters can be reprogrammed into a modem system with no disassembly of the modem hardware. The modem system includes a memory chip in which operating code and parameters are stored. Two control programs control the reprogramming of updated operating code. One of the control programs is designed for manufacturing and testing purposes. The other control program allows remote reprogramming of updated operating code or parameters from a remote location such as a customer site. A user can thus remotely upgrade system firmware with updates, bug fixes, enhancements or other new releases of system operating code by downloading the update over a phone line to a host PC and reprogramming the memory chip of the modem over the serial port from the host PC. The user can also remotely upgrade the modem system firmware by directly programing the memory chip of the modem without the assistance of the host PC. The modem system is portable, obtaining power from a standard 9 volt battery.

Abstract: Updated operating code and parameters can be reprogrammed into a modem system with no disassembly of the modem hardware. The modem system includes a memory chip in which operating code and parameters are stored. Two control programs control the reprogramming of updated operating code. One of the control programs is designed for manufacturing and testing purposes. The other control program allows remote reprogramming of updated operating code or parameters from a remote location such as a customer site. A user can thus remotely upgrade system firmware with updates, bug fixes, enhancements or other new releases of system operating code by downloading the update over a phone line to a host PC and reprogramming the memory chip of the modem over the serial port from the host PC. The user can also remotely upgrade the modem system firmware by directly programming the memory chip of the modem without the assistance of the host PC. The modem system is portable, obtaining power from a standard 9 volt battery.

Abstract: Updated operating code and parameters can be reprogrammed into a modem system with no disassembly of the modem hardware. The modem system includes a memory chip in which operating code and parameters are stored. Two control programs control the reprogramming of updated operating code. One of the control programs is designed for manufacturing and testing purposes. The other control program allows remote reprogramming of updated operating code or parameters from a remote location such as a customer site. A user can thus remotely upgrade system firmware with updates, bug fixes, enhancements or other new releases of system operating code by downloading the update over a phone line to a host PC and reprogramming the memory chip of the modem over the serial port from the host PC. The user can also remotely upgrade the modem system firmware by directly programming the memory chip of the modem without the assistance of the host PC. The modem system is portable, obtaining power from a standard 9 volt battery.

Abstract: Updated operating code and parameters can be reprogrammed into a modem system with no disassembly of the modem hardware. The modem system includes an in-circuit reprogrammable memory chip in which operating code and parameters are stored. Two control programs control the reprogramming of updated operating code. One of the control programs is designed for manufacturing and testing purposes. The other control program allows remote reprogramming of updated operating code or parameters from a remote location such as a customer site. The modem system is portable, obtaining power from a standard 9 volt battery. Therefor, various power saving features are also incorporated into the modem system.

Abstract: Updated operating code and parameters can be reprogrammed into a modem system with no disassembly of the modem hardware. The modem system includes an in-circuit reprogrammable memory chip in which operating code and parameters are stored. Two control programs control the reprogramming of updated operating code. One of the control programs is designed for manufacturing and testing purposes. The other control program allows remote reprogramming of updated operating code or parameters from a remote location such as a customer site. The modem system is portable, obtaining power from a standard 9 volt battery. Therefor, various power saving features are also incorporated into the modem system.