Patents by Inventor RICHARD DEAN BRAATZ
RICHARD DEAN BRAATZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11768249Abstract: System, methods, and other embodiments described herein relate to improving the estimation of battery life. In one embodiment, a method includes measuring electrochemical data of a battery cell associated with an electrochemical reaction triggered by a test during a diagnostic cycle. The method also includes determining a feature associated with the degradation of the battery cell from the electrochemical data. The method also includes predicting an end-of-life (EOL) of the battery cell by using the feature in a machine learning (ML) model.Type: GrantFiled: March 31, 2021Date of Patent: September 26, 2023Assignees: Toyota Research Institute, Inc., Massachusetts Institute of Technology, The Board of Trustees of the Leland Stanford Junior UniversityInventors: William C. Chueh, Bruis van Vlijmen, William E. Gent, Vivek Lam, Patrick K. Herring, Chirranjeevi Balaji Gopal, Patrick A. Asinger, Benben Jiang, Richard Dean Braatz, Xiao Cui, Gabriel B. Crane
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Patent number: 11614491Abstract: System, methods, and other embodiments described herein relate to improving the cycling of batteries by using data and a hierarchical Bayesian model (HBM) for predicting the cycle life of a cycling protocol. In one embodiment, a method includes classifying cycle life of a battery into a class using battery data from cycling with a protocol, wherein the class represents cycle life distributions of cycling protocols. The method also includes quantifying, using the class in a HBM, variability for the battery induced by the protocol. The method also includes predicting, using the HBM, an adjusted cycle life for the protocol according to the variability. The method also includes communicating the adjusted cycle life to operate the battery.Type: GrantFiled: April 20, 2021Date of Patent: March 28, 2023Assignees: Toyota Research Institute, Inc., Massachusetts Institute of Technology, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Richard Dean Braatz, Benben Jiang, Fabian Mohr, Michael Forsuelo, William E. Gent, Patrick K. Herring, William C. Chueh, Stephen J. Harris
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Publication number: 20230053902Abstract: Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments; these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.Type: ApplicationFiled: March 9, 2022Publication date: February 23, 2023Applicants: Massachusetts Institute of Technology, Rensselaer Polytechnic InstituteInventors: J. Christopher Love, Kerry R. Love, Laura Crowell, Alan Stockdale, Richard Dean Braatz, Amos Enshen Lu, Steven Cramer, Steven Timmick, Nicholas Vecchiarello, Chaz Goodwine, Craig A. Mascarenhas
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Publication number: 20220341995Abstract: System, methods, and other embodiments described herein relate to improving the cycling of batteries by using data and a hierarchical Bayesian model (HBM) for predicting the cycle life of a cycling protocol. In one embodiment, a method includes classifying cycle life of a battery into a class using battery data from cycling with a protocol, wherein the class represents cycle life distributions of cycling protocols. The method also includes quantifying, using the class in a HBM, variability for the battery induced by the protocol. The method also includes predicting, using the HBM, an adjusted cycle life for the protocol according to the variability. The method also includes communicating the adjusted cycle life to operate the battery.Type: ApplicationFiled: April 20, 2021Publication date: October 27, 2022Applicants: Toyota Research Institute, Inc., The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of TechnologyInventors: Richard Dean Braatz, Benben Jiang, Fabian Mohr, Michael Forsuelo, William E. Gent, Patrick K. Herring, William C. Chueh, Stephen J. Harris
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Publication number: 20220137149Abstract: System, methods, and other embodiments described herein relate to improving the estimation of battery life. In one embodiment, a method includes measuring electrochemical data of a battery cell associated with an electrochemical reaction triggered by a test during a diagnostic cycle. The method also includes determining a feature associated with the degradation of the battery cell from the electrochemical data. The method also includes predicting an end-of-life (EOL) of the battery cell by using the feature in a machine learning (ML) model.Type: ApplicationFiled: March 31, 2021Publication date: May 5, 2022Applicants: Toyota Research Institute, Inc., The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of TechnologyInventors: William C. Chueh, Bruis van Vlijmen, William E. Gent, Vivek Lam, Patrick K. Herring, Chirranjeevi Balaji Gopal, Patrick A. Asinger, Benben Jiang, Richard Dean Braatz, Xiao Cui, Gabriel B. Crane
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Patent number: 11226374Abstract: A method of using data-driven predictive modeling to predict and classify battery cells by lifetime is provided that includes collecting a training dataset by cycling battery cells between a voltage V1 and a voltage V2, continuously measuring battery cell voltage, current, can temperature, and internal resistance during cycling, generating a discharge voltage curve for each cell that is dependent on a discharge capacity for a given cycle, calculating, using data from the discharge voltage curve, a cycle-to-cycle evolution of cell charge to output a cell voltage versus charge curve Q(V), generating transformations of ?Q(V), generating transformations of data streams that include capacity, temperature and internal resistance, applying a machine learning model to determine a combination of a subset of the transformations to predict cell operation characteristics, and applying the machine learning model to output the predicted battery operation characteristics.Type: GrantFiled: October 16, 2018Date of Patent: January 18, 2022Assignees: The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of TechnologyInventors: Kristen Ann Severson, Richard Dean Braatz, William C. Chueh, Peter M. Attia, Norman Jin, Stephen J. Harris, Nicholas Perkins
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Patent number: 10987636Abstract: Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).Type: GrantFiled: August 31, 2018Date of Patent: April 27, 2021Assignee: Massachusetts Institute of TechnologyInventors: J. Christopher Love, Craig A. Mascarenhas, Amos Enshen Lu, Richard Dean Braatz
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Publication number: 20200251186Abstract: Systems and methods for generating and evaluating candidate sequences of partitioning steps to partition at least one biologically produced product from at least one impurity. In some embodiments, a plurality of candidate sequences of partitioning steps may be generated, wherein at least one candidate sequence of the plurality of candidate sequences comprises a plurality of partitioning steps in a specified order. The plurality of candidate sequences may be evaluated. For instance, a data set associated with the at least one partitioning step may be accessed, the data set comprising: first data indicative of a behavior of the at least one biologically produced product with respect to the at least one partitioning step; and second data indicative of a behavior of the at least one impurity with respect to the at least one partitioning step. The at least one candidate sequence may be scored based at least in part on the data set.Type: ApplicationFiled: March 30, 2018Publication date: August 6, 2020Applicants: Massachusetts Institute of Technology, Rensselaer Polytechnic InstituteInventors: J. Christopher Love, Kerry R. Love, Steven Cramer, Steven Timmick, Nicholas Vecchiarello, Chaz Goodwine, Laura Crowell, Alan Stockdale, Richard Dean Braatz, Amos Enshen Lu
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Publication number: 20200224144Abstract: Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments, these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.Type: ApplicationFiled: March 30, 2018Publication date: July 16, 2020Applicants: Massachusetts Institute of Technology, Rensselaer Polytechnic InstituteInventors: J. Christopher Love, Kerry R. Love, Laura Crowell, Alan Stockdale, Richard Dean Braatz, Amos Enshen Lu, Steven Cramer, Steven Timmick, Nicholas Vecchiarello, Chaz Goodwine, Craig A. Mascarenhas
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Publication number: 20190113577Abstract: A method of using data-driven predictive modeling to predict and classify battery cells by lifetime is provided that includes collecting a training dataset by cycling battery cells between a voltage V1 and a voltage V2, continuously measuring battery cell voltage, current, can temperature, and internal resistance during cycling, generating a discharge voltage curve for each cell that is dependent on a discharge capacity for a given cycle, calculating, using data from the discharge voltage curve, a cycle-to-cycle evolution of cell charge to output a cell voltage versus charge curve Q(V), generating transformations of ?Q(V), generating transformations of data streams that include capacity, temperature and internal resistance, applying a machine learning model to determine a combination of a subset of the transformations to predict cell operation characteristics, and applying the machine learning model to output the predicted battery operation characteristics.Type: ApplicationFiled: October 16, 2018Publication date: April 18, 2019Inventors: Kristen Ann Severson, Richard Dean Braatz, William C. Chueh, Peter M. Attia, Norman Jin, Stephen J. Harris, Nicholas Perkins
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Publication number: 20190070564Abstract: Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).Type: ApplicationFiled: August 31, 2018Publication date: March 7, 2019Applicant: Massachusetts Institute of TechnologyInventors: J. Christopher Love, Craig A. Mascarenhas, Amos Enshen Lu, Richard Dean Braatz
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Publication number: 20170354609Abstract: The disclosure describes an injection molding process for coating a tablet core to produce a coated pharmaceutical tablet, wherein the injection-molded coating is substantially continuous (e.g., completely covers the tablet core with no openings), and describes the resulting coated pharmaceutical tablet. The disclosure describes compositions for coatings and tablet cores and equipment suitable for performing the process.Type: ApplicationFiled: June 12, 2017Publication date: December 14, 2017Applicant: Massachusetts Institute of TechnologyInventors: Vibha Puri, Parind Mahendrakumar Desai, Keith D. Jensen, David Brancazio, Eranda Harinath, Alexander Racine Martinez, Jung Hoon Chun, Richard Dean Braatz, Allan S. Myerson, Bernhardt Levy Trout
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Publication number: 20160289173Abstract: The present invention generally relates to devices and methods for crystallizing a compound. In certain industries, crystallization techniques require additional filtration steps in order to obtain products of relatively high yield and/or high purity. In some embodiments, the devices and methods described herein facilitate continuous production of high yield and/or high purity products without the need for additional filtration steps. In some embodiments, the devices and methods comprise flowing a fluid comprising a compound (e.g., a crystallizable compound, a solidifiable compound) over a substrate such that the compound crystallizes and/or precipitates on the substrate. In some embodiments, the crystallized compound can be recovered (e.g., at a high purity in solution). In certain embodiments, the substrate is orientated substantially vertically (e.g., such that flow of the fluid is driven by gravity). In some cases, the substrate comprises a plurality of crystallization promoting structures.Type: ApplicationFiled: March 30, 2016Publication date: October 6, 2016Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: ALLAN STUART MYERSON, RICHARD DEAN BRAATZ, STEVEN THOMAS FERGUSON, MIN SU, BERNHARDT LEVY TROUT, LIFANG ZHOU, NIMA YAZDAN PANAH