Patents by Inventor Richard Dennis DiMarchi

Richard Dennis DiMarchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyethylene glycol linked GLP-1 compounds
    Patent number: 7557183
    Abstract: The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: July 7, 2009
    Assignee: Eli Lilly and Company
    Inventors: Richard Dennis DiMarchi, Wolfgang Glaesner, Rohn Lee Millican, Jr., Andrew Mark Vick, Lianshan Zhang
  • Polyethylene Glycol Linked Glp-1 Compounds
    Publication number: 20080113905
    Abstract: The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.
    Type: Application
    Filed: March 19, 2004
    Publication date: May 15, 2008
    Applicant: ELI LILLY AND COMPANY
    Inventors: Richard Dennis DiMarchi, Wolgang Glaesner, John Lee Millican Jr, Andrew Mark Vick, Lianshan Zhang
  • Pre-mixes of GLP-1 and basal insulin
    Patent number: 7238663
    Abstract: The present invention encompasses pre-mixed formulations comprising a GLP-1 polypeptide and a basal insulin.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: July 3, 2007
    Assignee: Eli Lilly and Company
    Inventors: Michael Rosario DeFelippis, Richard Dennis DiMarchi, Kingman Ng
  • Amidated glucagon-like peptide-1
    Patent number: 7199217
    Abstract: The present invention encompasses a GLP-1 analog and compositions and formulations thereof useful for the treatment of hyperglycemia and other various diseases and conditions in mammals.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: April 3, 2007
    Assignee: Eli Lilly and Company
    Inventors: Richard Dennis DiMarchi, Rohn Lee Millican, Jr., Wolfgang Glaesner
  • Biphasic mixtures of GLP-1 and insulin
    Patent number: 7179788
    Abstract: The present invention encompasses pharmaceutical formulations comprising a biphasic mixture which comprises a glucagon like peptide (GLP-1) compound in a solid phase and an insulin in a solution phase.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: February 20, 2007
    Assignee: Eli Lilly and Company
    Inventors: Michael Rosario DeFelippis, Richard Dennis DiMarchi, Kingman Ng, Michael Ernst Trautmann
  • Biphasic mixtures of glp-1 and insulin
    Publication number: 20040254107
    Abstract: The present invention encompasses pharmaceutical formulations comprising a biphasic mixture which comprises a glucagon like peptide (GLP-1) compound in a solid phase and an insulin in a solution phase.
    Type: Application
    Filed: March 19, 2004
    Publication date: December 16, 2004
    Inventors: Michael Rosario DeFelippis, Richard Dennis DiMarchi, Kingman Ng, Michael Ernst Trautmann
  • Pre-mixes of glp-1 and basal insulin
    Publication number: 20040235710
    Abstract: The present invention encompasses pre-mixed formulations comprising a GLP-1 polypeptide and a basal insulin.
    Type: Application
    Filed: February 9, 2004
    Publication date: November 25, 2004
    Inventors: Michael Rosario DeFelippis, Richard Dennis DiMarchi, Kingman Ng
  • Method for administering monomeric insulin
    Publication number: 20040214747
    Abstract: The claimed invention relates to a method of administering AspB28-human insulin by inhalation, a method for treating diabetes by administering AspB28-human insulin by inhalation, and a method for treating hyperglycemia by administering AspB28-human insulin by inhalation.
    Type: Application
    Filed: May 24, 2004
    Publication date: October 28, 2004
    Inventors: Richard Dennis DiMarchi, Roger Garrick Harrison, Ronald Keith Wolff
  • Amidated glucagon-like peptide-1
    Publication number: 20040132647
    Abstract: The present invention encompasses a GLP-1 analog and compositions and formulations thereof useful for the treatment of hyperglycemia and other various diseases and conditions in mammals.
    Type: Application
    Filed: June 10, 2003
    Publication date: July 8, 2004
    Inventors: Richard Dennis DiMarchi, Rohn Lee Millican Jr, Wolfgang Glaesner
  • METHOD FOR ADMINISTERING ASPB28-HUMAN INSULIN
    Publication number: 20010053761
    Abstract: The claimed invention relates to a method of administering AspB28-human insulin by inhalation, a method for treating diabetes by administering AspB28-human insulin by inhalation, and a method for treating hyperglycemia by administering AspB28-human insulin by inhalation.
    Type: Application
    Filed: January 6, 1999
    Publication date: December 20, 2001
    Inventors: RICHARD DENNIS DIMARCHI, ROGER GARRICK HARRISON, RONALD KEITH WOLFF
  • METHOD FOR ADMINISTERING MONOMERIC INSULIN ANALOGS
    Publication number: 20010007853
    Abstract: The claimed invention relates to a method of administering an insulin analog by inhalation, a method for treating diabetes by administering an insulin analog by inhalation, and a method for treating hyperglycemia by administering an insulin analog by inhalation.
    Type: Application
    Filed: January 6, 1999
    Publication date: July 12, 2001
    Inventors: RICHARD DENNIS DIMARCHI, ROGER GARRICK HARRISON, RONALD KEITH WOLFF
  • Method of treating insulin resistance
    Patent number: 5939387
    Abstract: The present invention is in the field of human medicine, particularly in the treatment of Non-insulin Dependent Diabetes Mellitus (NIDDM) and other insulin resistant states such as those associated with obesity and aging. The invention provides a method of treating insulin resistant mammals, which comprises administering to a mammal in need thereof a growth hormone releasing agent.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: August 17, 1999
    Assignee: Eli Lilly and Company
    Inventors: Carol Lynn Broderick, Richard Dennis DiMarchi, Mark Louis Heiman, Lawrence Edward Stramm