Abstract: The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.

Abstract: The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.

Abstract: The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.

Abstract: The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.

Abstract: The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.

Abstract: The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.

Abstract: The present invention provides methods for wound management that comprise contacting a wound of a patient with an effective amount of a therapeutic composition comprising a chelating agent, a pH buffering agent, an antimicrobial agent, Vitamin E and a carrier and a surfactant. The antimicrobial agent(s) has increased antimicrobial activity because of the synergy with the chelating agent and maintenance of the treated area at a pH suitable for sustained antibiotic activity so that the antimicrobial agent can be used in effective doses that are less than in the absence of the chelator. The Vitamin E promotes tissue repair, reducing the likelihood of opportunistic infection, improving wound healing and reducing pain sensation. The wound management methods of the present invention further include contacting the wound with a medical dressing having an effective amount of the composition deposited thereon.

Abstract: The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or aquaria. The present invention provides bathing and dipping methods for reducing a microbial infection of an animal with an antibiotic solution of enhanced antimicrobial activity comprising at least one chelating agent and at least one antibiotic effective against the microbial infection. The present invention also provides a method for reducing a microbial infection of an animal comprising bathing or dipping an animal having a microbial infection in an antimicrobial solution comprising the chelating agent EDTA, and at least one antibiotic, and optionally a pH buffering agent. The immersion of the aquatic animal in the antimicrobial solution containing the EDTA, antibiotic and pH buffering agent may be repeated until the microbial burden of the animal is eliminated.

Abstract: The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or aquaria. The present invention provides bathing and dipping methods for reducing a microbial infection of an animal with an antibiotic solution of enhanced antimicrobial activity comprising at least one chelating agent and at least one antibiotic effective against the microbial infection. The present invention also provides a method for reducing a microbial infection of an animal comprising bathing or dipping an animal having a microbial infection in an antimicrobial solution comprising the chelating agent EDTA, and at least one antibiotic, and optionally a pH buffering agent. The immersion of the aquatic animal in the antimicrobial solution containing the EDTA, antibiotic and pH buffering agent may be repeated until the microbial burden of the animal is eliminated.

Abstract: The present invention relates to methods of inhibiting the proliferation of a microbial population of a surface lesion of a human or animal, wherein the lesion is contacted with an antimicrobial composition comprising a pharmaceutically acceptable antibiotic, a pharmaceutically acceptable chelating agent and a pharmaceutically acceptable pH buffering agent. Another aspect of the present invention is a medical dressing for delivering an antimicrobial composition to a site of a skin injury or lesion of a mammal, comprising a support and an antimicrobial composition, wherein the antimicrobial composition is at least one antimicrobial agent and at least one chelating agent. The present invention also relates to methods for delivering an antibiotic to an injury to the skin of a human or animal and to kits for the preparation and use of an antimicrobial composition to inhibit a microbial infection of a skin injury or lesion of a human or animal.

Abstract: The invention includes novel strains of E. coli and methods for treating livestock with strains of the invention to inhibit growth of S. typhimurium as well as other pathogenic enterobacteria, such as E. coli 0157:H7, in the intestinal tract of treated animals. By inhibiting growth of such contaminant pathogenic organisms in the intestinal tract of treated animals, the number of such organisms living in the animals, or excreted into the environment, is reduced or eliminated. The potential for re-introduction and for contamination of meat and other products is concomitantly reduced or eliminated.