Patents by Inventor Richard F. Clark

Richard F. Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NAMPT INHIBITORS
    Publication number: 20130303511
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
    Type: Application
    Filed: May 10, 2013
    Publication date: November 14, 2013
    Applicant: AbbVie Inc.
    Inventors: Richard F. Clark, Bryan Sorensen, Augustine T. Osuma, Robin Frey, Kenton Longenecker, George Doherty, Michael L. Curtin, Michael R. Michaelides, Ramzi F. Sweis, Marina A. Pliushchev, Andy Judd, Todd M. Hansen, Howard R. Heyman
  • NAMPT INHIBITORS
    Publication number: 20130303508
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
    Type: Application
    Filed: May 10, 2013
    Publication date: November 14, 2013
    Applicant: ABBVIE INC.
    Inventors: Richard F. Clark, Bryan Sorensen, Augustine T. Osuma, Robin Frey, Kenton Longenecker, George Doherty, Michael L. Curtin, Michael R. Michaelides, Ramzi F. Sweis, Marina A. Pliushchev, Andy Judd, Todd M. Hansen, Howard R. Heyman
  • NAMPT INHIBITORS
    Publication number: 20130303509
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
    Type: Application
    Filed: May 10, 2013
    Publication date: November 14, 2013
    Applicant: ABBVIE INC.
    Inventors: Todd M. Hansen, Kenton Longenecker, Howard R. Heyman, Michael L. Curtin, Richard F. Clark, Bryan Sorensen, Zhiqin Ji, Kevin Woller, George Doherty, Robin Frey
  • Pyrimidine inhibitors of kinase activity
    Patent number: 8536180
    Abstract: Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R are also disclosed.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: September 17, 2013
    Assignee: AbbVie Inc.
    Inventors: Richard F. Clark, Nwe Y. Ba-maung, Scott A. Erickson, Steve D. Fidanze, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang, Randy L. Bell
  • Pyrimidine inhibitors of kinase activity
    Patent number: 8354422
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: January 15, 2013
    Assignee: Abbott Laboratories Inc.
    Inventors: Richard F. Clark, Randy L. Bell, Nwe Y. Ba-maung, Scott A. Erickson, Steve D. Fidanze, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang
  • NAMPT AND ROCK INHIBITORS
    Publication number: 20120122842
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: Abbott Laboratories
    Inventors: Michael L. Curtin, Bryan K. Sorensen, Howard R. Heyman, Richard F. Clark, Kevin R. Woller, Omar J. Shah, Michael Michaelides, Chris Tse, Anil Vasudevan, Helmut Mack, Todd M. Hansen, Ramzi Sweis, Marina A. Pliushchev
  • Protein kinase inhibitors
    Patent number: 8067409
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: November 29, 2011
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. Ba-Maung, Randy L. Bell, Richard F. Clark, Scott A. Erickson, Steve D. Fidanze, Robert D. Hubbard, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang
  • PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES
    Publication number: 20110281842
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora.
    Type: Application
    Filed: May 12, 2011
    Publication date: November 17, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Michaelides, Andrew S. Judd, Shannon R. Fix-Stenzel, Richard F. Clark, Bryan K. Sorensen, Zhiqin Ji
  • SHEAR- AND/OR PRESSURE-RESISTANT MICROSPHERES
    Publication number: 20110177341
    Abstract: The resistance of hollow microspheres towards shear and pressure may be enhanced by forming a non-tacky, solid, non-particulate outer coating comprised of a non-thermoset film-forming material on the outer surfaces of such microspheres.
    Type: Application
    Filed: March 30, 2011
    Publication date: July 21, 2011
    Applicant: Henkel Corporation
    Inventors: Richard F. Clark, David R. Meloon, Jessica Killion
  • Nonflammable hollow polymeric microspheres
    Publication number: 20110178197
    Abstract: Hollow polymeric microspheres may be rendered nonflammable by coating with one or more flame retardants, while maintaining a composite density of not greater than 0.05 g/cm3.
    Type: Application
    Filed: March 30, 2011
    Publication date: July 21, 2011
    Applicant: Henkel Corporation
    Inventors: Richard F. Clark, Jessica Killion
  • IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION
    Publication number: 20110124632
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: October 18, 2010
    Publication date: May 26, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Nwe Y. Ba-maung, Richard F. Clark, Scott A. Erickson, Steve D. Fidanze, Megumi Kawai, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang
  • Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
    Patent number: 7928243
    Abstract: The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: April 19, 2011
    Assignee: Abbott Laboratories
    Inventors: Yu Gui Gu, Richard F. Clark, Qun Li, Moshe Weitzberg, Hing Sham
  • Pyrimidine Inhibitors of Kinase Activity
    Publication number: 20100305126
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Richard F. Clark, Randy L. Bell, Nwe Y. Ba-maung, Scott A. Erickson, Steve D. Fidanze, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang
  • PYRIMIDINE INHIBITORS OF KINASE ACTIVITY
    Publication number: 20100305118
    Abstract: Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R are also disclosed.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Richard F. Clark, Nwe Y. Ba-maung, Scott A. Erickson, Steve D. Fidanze, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang, Randy L. Bell
  • PROTEIN KINASE INHIBITORS
    Publication number: 20090253723
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: November 20, 2008
    Publication date: October 8, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Nwe Y. Ba-Maung, Randy L. Bell, Richard F. Clark, Scott A. Erickson, Steve D. Fidanze, Robert D. Hubbard, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang
  • NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME
    Publication number: 20080161368
    Abstract: The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
    Type: Application
    Filed: December 5, 2007
    Publication date: July 3, 2008
    Inventors: Yu Gui Gu, Richard F. Clark, Qun Li, Moshe Weitzberg, Hing Sham
  • Ultra low density thermally clad microspheres and method of making same
    Patent number: 7368167
    Abstract: Microsphere beads are mixed with a surface barrier solid, liquid or mixture of such a liquid with a solid effective to prevent agglomeration and surface bonding of the microspheres; by the control of the application of heat and balancing temperature and active mixing, removal of water from and expansion of the microsphere is achieved. Microsphere densities of as low as 0.005 to less than 0.015 g/cm3 are realized. The surface barrier solid, liquid or mixture of such a liquid with a solid in the present invention is any one of a wide diversity of materials which meet the requirements of the intended function, i.e., to prevent the agglomeration of the microspheres during the process. Suitable materials include, by way of example, fillers, pigments, plasticizers, diluents, extenders, monomers and oligomers and the like.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: May 6, 2008
    Assignee: Henkel Corporation
    Inventors: Richard W Johnston, Richard F. Clark
  • Thienopyridones as AMPK activators for the treatment of diabetes and obesity
    Patent number: 7119205
    Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: October 10, 2006
    Assignee: Abbott Laboratories
    Inventors: Rajesh R. Iyengar, Andrew S. Judd, Gang Zhao, Philip R. Kym, Hing L. Sham, Yugui Gu, Gang Liu, Mei Liu, Hongyu Zhao, Richard F. Clark, Ernst U. Frevert, Barbara L. Cool, Tianyuan Zhang, Robert F. Keyes, Todd M. Hansen, Zhili Xin
  • Antibacterial compounds with improved pharmacokinetic profiles
    Publication number: 20040033970
    Abstract: Antibacterial compounds with improved pharmacokinetic profiles having formula (I) 1
    Type: Application
    Filed: April 24, 2003
    Publication date: February 19, 2004
    Inventors: Richard F. Clark, Stevan Djuric, Zhenkun Ma, Ly Phan, Michael Rupp
  • 6-O-substituted ketolides having antibacterial activity
    Patent number: RE39591
    Abstract: Antimicrobial compounds having the formula as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: April 24, 2007
    Assignee: Abbott Laboratories
    Inventors: Yat Sun Or, Zhenkun Ma, Richard F. Clark, Daniel T. Chu, Jacob J. Plattner, George Griesgraber