Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: Methods for treating cancer patients with human platelet derived growth factor receptor alpha inhibiting compounds, in which the patient is identified as having a cancer that is human platelet derived growth factor receptor beta negative.

Abstract: The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.

Abstract: A system and method for identifying abnormal medical images. The system can be configured to receive a medical image, segment an anatomical structure from the medical image to define a segmented dataset, register the segmented dataset to a baseline dataset defining a normal anatomical structure, classify, by an abnormality classifier, whether the anatomical structure within the medical image as either abnormal or normal, wherein the abnormality classifier comprises a machine learning algorithm trained to distinguish between normal and abnormal versions of the anatomical structure in medical images, and based on whether the anatomical structure can be segmented from the medical image, whether the segmented dataset can be registered to the baseline dataset, or a classification associated with the medical image output by the abnormality classifier, flagging the medical image as either normal or abnormal.

Abstract: In some examples, a processor may access past order information for a plurality of merchants to determine, for an upcoming time period, a number of orders predicted to be received by the merchants. The processor may determine geographic locations of delivery agent devices, each associated with a respective delivery agent. The processor may compare, for the upcoming time period, a number of active delivery agents with the number of orders predicted to be received. Based at least on determining a predicted shortage of active delivery agents for the upcoming time period, the processor selects a first delivery agent of the plurality of delivery agents to pick up a first order from a first pickup location of a first merchant and a second order from a second pickup location of a second merchant, and sends a message to a first delivery agent device associated with the first delivery agent.

Abstract: A method of designing a grout material for an anchoring pile system based on the analysis of a stress state of the anchoring pile constructed into a subterranean formation. An advisory process can utilize a model to produce a numerical model of the anchoring pile, a model to determine the operational loads, a model to determine the grout material, and a model to determine the stress state of the grout interfaces. The group of models can determine a probability of failure of the grout material, a probability of failure of a grout interface, and a predicted lifespan of the grout materials.

Abstract: A child safety seat and base assembly wherein a base is arranged to be secured with respect to a motor vehicle and a seat is arranged to be removably secured is disclosed. The assembly includes: a rotary element rotatably mounted to the base; a seat latch on the rotary element that engages the child safety seat to releasably hold the child safety seat to the base and rotary element; a seat latch actuation assembly for opening or closing the seat latch wherein opening the seat latch releases the child safety seat; and an interlock mechanism actuated upon opening the seat latch that prevents rotation of the rotary element with respect to the base. The seat latch actuation assembly may include a slidably mounted handle, wherein in use, the base blocks access to the handle when the seat is in any position other than one or two side-loading position(s).

Abstract: Methods and systems for modifying a plug container to permit a fiber pass-through allowing data to be communicated from a pressurized environment into a non-pressurized environment. The systems and methods including surrounding a communication line with a protective sheath coupled with a top plug and a cap of a plug container including an elongated body having a flow path therethrough. The cap including a pass-through for receiving the communication line and obtaining data corresponding to one or more wellbore conditions including at least a temperature, a pressure, and a top plug location.

Abstract: The present invention is generally related to a high capacity, high efficiency nonwoven filtration media comprising a gradient pore structure. In particular, the filtration media can comprise thermoplastic synthetic microfibers, fibrillated fibers, staple fibers, and a binder. Furthermore, the filtration media may be produced without the use of glass fibers or microglass fibers. Consequently, the filtration media of the present invention does not cause the same issues as conventional filtration media that comprises glass fibers and/or microglass fibers. Moreover, the filtration media can be used to treat fuel, lubrication fluids, hydraulic fluids, and various other industrial gases.

Abstract: A method of designing a cement pumping procedure of a wellbore isolation barrier with a design application receiving customer inputs comprising a plurality of wellbore data and a job objective. The design application can retrieve a cement pumping procedure from a data source comprising a series of sequential steps to achieve the job objective. The design application can load the customer inputs into the cement pumping procedure, access a database of best practices, calculate a probability score for achieving the job objective based on a model, and recommend modifying one or more steps of the cement pumping procedure with one or more best practices in response to the probability score being below a threshold.

Abstract: The invention relates to a child safety seat (100) comprising an integral harness belt (102) for restraining a child in the child safety seat (100), a belt tension monitor (106) adapted for monitoring a belt tension acting on the harness belt (102), a motorized harness belt tensioner (104) comprising a tensioning element (114) driven by an electromechanical actuator (122) and adapted for adjusting the belt tension acting on the harness belt (102), and a controller adapted for controlling the motorized harness belt tensioner (104) to adjust the belt tension to match a first predefined belt tension and for monitoring the resulting belt tension using the belt tension monitor (106).

Abstract: The present invention is generally related to a high capacity, high efficiency nonwoven filtration media comprising a gradient pore structure. In particular, the filtration media can comprise thermoplastic synthetic microfibers, fibrillated fibers, staple fibers, and a binder. Furthermore, the filtration media may be produced without the use of glass fibers or microglass fibers. Consequently, the filtration media of the present invention does not cause the same issues as conventional filtration media that comprises glass fibers and/or microglass fibers. Moreover, the filtration media can be used to treat fuel, lubrication fluids, hydraulic fluids, and various other industrial gases.

Abstract: A non-limiting example of a computer-implemented method for error injection includes executing a pre-silicon operation on a simulated chip verifying that a plurality of latches from a timing simulation set error checkers when run against a manufacturing test suite in order to generate a cross-reference file containing latch entries in a table. It executes a first post-silicon operation on a hardware chip based on the simulated chip to determine empirically that timing latches from logic built-in self tests (“LBIST”) trigger the same error checkers set by the plurality of latches verified in the simulated chip. The method updates the cross-reference file based on the results of the determination. The method executes a second post-silicon operation on the hardware chip to improve chip frequency by working around functional checkers using the cross-reference file and updating the cross-reference file based on the results of the improving.

Abstract: The invention relates to a child safety seat (100) comprising an integral harness belt (106) for restraining a child in the child safety seat (100), a deflector (102) for the harness belt (106), an elastic mechanism (104) adapted for forcing the deflector (102) from a first position (114) to a second position (112), the harness belt (106) being guided by the deflector (102), wherein due to the guidance by the deflector (102) the harness belt (106) length available for buckling in the child is shorter in the second position (112) than in the first position (114), a latch mechanism transferable between a blocking position and a release position, the latch mechanism being adapted for blocking in the blocking position the deflector (102) against a movement toward the second position (112) and for releasing in the release position the deflector (102) for a movement induced by the forcing toward the second position (112), a release mechanism adapted for transferring the latch mechanism from the blocking position to

Abstract: A medical devices en-vivo positional determination system using a plurality of optical time of flight (TDF) transceivers along with gyroscopic angular and mechanical distance sensors for the determination of absolute linear and angular positional information of the tool bit tip for the purposes of more accurate hand-held drilling or cutting, on the workpiece using forward kinematic equations calculated on a microcomputer to provide a real-time display of the 3-linear position and 2-angular orientation of the tool bit (such as a drill, scalpel, or wire driver).

Abstract: Biomechanically, a human foot operates as a lever of the second class during the motions involved with walking, running or jumping. Extending the toes during such motion increases the distance between the fulcrum and effort of the foot-lever and results in increased foot propulsion.

Abstract: A method of evaluating a stress state of a wellbore isolation barrier with an evaluation application receiving a data set, obtained from wellbore sensors, from a remote data source by one or more communication methods. The data set comprises periodic wellbore data indicative of the stress state of the wellbore isolation barrier. The evaluation application may determine a modeled stress state of the wellbore isolation barrier by evaluating a data set consisting of the received data. The evaluation application may generate an alert if the model stress state exceeds a user threshold.

Abstract: The method and system determine and report measures of adherence of patients to prescription medication regimens based upon fill gaps in the prescription history of the patients. The measure of adherence may be the proportion of days covered by the medication. The method and system may receive or access information relating to a patient's medical history, including past prescription medication fills. Fills of both the prescription medication and other medications that may substitute for the prescription medication may be considered in determining patient adherence levels. Upon determining the patient's level of adherence, the system and method may generate a report including the adherence information and associated information, such as a home pharmacy location. The report may include an indication of whether new-to-therapy information should be presented to a patient based on patient adherence levels.

Abstract: A system and method for identifying abnormal medical images. The system can be configured to receive a medical image, segment an anatomical structure from the medical image to define a segmented dataset, register the segmented dataset to a baseline dataset defining a normal anatomical structure, classify, by an abnormality classifier, whether the anatomical structure within the medical image as either abnormal or normal, wherein the abnormality classifier comprises a machine learning algorithm trained to distinguish between normal and abnormal versions of the anatomical structure in medical images, and based on whether the anatomical structure can be segmented from the medical image, whether the segmented dataset can be registered to the baseline dataset, or a classification associated with the medical image output by the abnormality classifier, flagging the medical image as either normal or abnormal.

Abstract: Examples described herein provide a computer-implemented method that includes initiating a logic built-in self-test (LBIST) of a device under test (DUT). The method further includes performing latch state counting using a multiple input signature register (MISR) of the DUT, the performing responsive to the MISR being in a counter mode. The method further includes performing a latch transition counting of latches of the DUT using the MISR of the DUT and a storage latch, the performing responsive to the MISR being in the counter mode. The method further includes performing a latch count comparison by comparing an output of the MISR responsive to the MISR being in the counter mode to an output of a count compare register, the output of the count compare register representing a desired MISR state.