Abstract: The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.

Abstract: The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.

Abstract: Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.

Abstract: Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.

Abstract: The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization experiments. Such arrays may utilize very small fluid volumes, in the order of picoliters. The method is especially suited to preparing combinatorial libraries useful in developing techniques for crystallizing biomacromolecules, such as proteins. The small volumes conserve macromolecules that may be costly and rare, and permit the testing of a large number of experimental crystallization conditions for a given amount of a macromolecule. The time required for the experiments may be very short due to the small volumes. The invention is conducive to forming high-density microarrays of small volume crystallization experiments. Acoustic detection of crystals in situ, and distinction between biomacromolecular and non-biomacromolecular crystals, are also taught.

Abstract: A method of decoding a plurality of glyphs comprising the steps of scanning a group of glyphs to form image data for expected glyph locations, assigning for each location a first value indicative of the likelihood that location contains a glyph in a first state, assigning for each location a second value indicative of the likelihood that location contains a glyph in a second state, determining the difference between the first and second values for each potential glyph location, establishing a distribution analysis of the determined differences and using that distribution analysis at least in part to control decoding of the plurality of glyphs.

Abstract: The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form small volumes high throughput combinatorial experimentation for crystallization. The method is especially suited to preparing combinatorial libraries of small volume crystallization experiments for crystallizing difficult to crystallize biomacromolecules. The small volumes conserve costly and difficult to obtain macromolecules and permit an increased number of experimental crystallization conditions tested for an amount of the biomacromolecule of interest for crystallization. The time required for the experiments is greatly reduced by the scaled down experimental volumes. The invention is conducive to forming high density microarrays of small volume crystallization experiments. Acoustic detection of crystals in situ and distinction between biomacromolecular and non-biomacromolecular crystals is also taught.

Abstract: A method of forming and moving ink drops across a gap between a print head and a print medium, or intermediate print medium, in a marking device includes generating an electric field, forming the ink drops adjacent the print head and controlling the electric field. The electric field is generated to extend across the gap. The ink drops are formed in an area adjacent the print head. The electric field is controlled such that an electrical attraction force exerted on the formed ink drops by the electric field is the greatest force acting on the ink drops. The marking device may be incorporated into a transfuse printing system having an intermediate print medium made of one or more materials that allow for lateral dissipation of electrical charge from the incident ink drops.

Abstract: The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization experiments. Such arrays may utilize very small fluid volumes, in the order of picoliters. The method is especially suited to preparing combinatorial libraries useful in developing techniques for crystallizing biomacromolecules, such as proteins. The small volumes conserve macromolecules that may be costly and rare, and permit the testing of a large number of experimental crystallization conditions for a given amount of a macromolecule. The time required for the experiments may be very short due to the small volumes. The invention is conducive to forming high-density microarrays of small volume crystallization experiments. Acoustic detection of crystals in situ, and distinction between biomacromolecular and non-biomacromolecular crystals, are also taught.

Abstract: A system for improving the uniformity of ink droplets delivered from a plurality of droplet sources on a printhead is described. The system includes a cooling system that compensates for nonuniform heating effects in a printhead which results in nonuniform temperatures. The distribution of the cooling system, and the effectiveness of the cooling system is set to maintain an approximately uniform ink temperature across the printhead.

Abstract: The present invention provides a method and device for the acoustic ejection of fluid droplets from fluid-containing reservoirs using focusing means having an F-number greater than approximately 2. The droplets are ejected toward designated sites on a substrate surface for deposition thereon. In one embodiment, the device is comprised of: a plurality of reservoirs each adapted to contain a fluid; an ejector comprising a means for generating acoustic radiation and a large F-numbered means for focusing the acoustic radiation at a focal point near the fluid surface in each of the reservoirs; and a means for positioning the ejector in acoustically coupled relationship to each of the reservoirs. The invention is useful in a number of contexts, particularly in the preparation of biomolecular arrays.

Abstract: A user interface is implemented using visual indicia and a background for the visual indicia that encodes address information. The background appears visually as a stipple pattern, but is implemented using glyphs which form an address carpet that encodes address information uniquely identifying each location of the user interface. An image capture device is used to capture an area of the address carpet that is at or near visual indicia of interest to the user while selecting a location in the visual indicia. The image capture device captures the area of interest, and transmits the image area to a computer for processing. The computer first determines the proper orientation of the image, and then decodes the information encoded by the glyphs. The decoding results in an X, Y address identifying the location of the captured area in the address carpet and, by reference, the address of the selected location. Based on the address, the computer may perform an operation associated with the area.

Abstract: A method and apparatus which laterally focuses aqueous ink drops onto a substrate, using electric fields. The drops are not charged, and focusing results from the forces on the uncharged dielectric drop that occur in a nonuniform electric field. It is shown that initial lateral velocity misdirection of the drops is corrected using electric fields. Lateral velocities which would produce drop displacements of ˜50 &mgr;m from their intended positions, at a height of 1 mm above the ink surface, may be corrected to produce displacements of less than 2.5 &mgr;m.

Abstract: A captured image includes a portion of a set of two-dimensional address codes. The portion of address codes can be decoded to determine a discrete pointer uniquely defining the portion. The captured image is first processed to determine the orientation of the portion, and then decoded based on the orientation to determine the discrete pointer. To determine the orientation of the portion, the portion is first analyzed to determine values at discrete locations within the portion. The values at each location form a matrix of binary data. The values of the matrix are then correlated to determine an orientation of the captured portion of two dimensional address codes. After determining the orientation of the portion, the values can be further analyzed to determine a discrete pointer that identifies the location of the portion within the address space defined by the two-dimensional address codes.

Abstract: A self-clocking glyph code is provided for encoding n-bit long digital values (where n>1) in a logically ordered sequence of composite glyphs that are written, printed, or otherwise recorded on a hardcopy recording medium in accordance with a predetermined spatial formatting rule. As used herein, a "composite glyph" is a graphical symbol that has a plurality of predefined, substantially orthogonal, graphical characteristics; each of which is capable of assuming any one of a plurality of predefined graphical states. An n-bit long digital value is distributively encoded in a glyph of this type by decomposing its n-bits, prior to or during the encoding, into a plurality of shorter, ordered, non-overlapping bit strings. The digital values of these bit strings, in turn, are encoded in the states of respective graphical characteristics of the composite glyph in a predetermined logical order, thereby preserving the logical ordering of the bit strings.

Abstract: An image display/processing apparatus which integrates as a single unit a two-dimensional (2-D) display, such as an LCD, with a two-dimensional (2-D) sensor array, such as a photodiode array. The arrays are aligned with a pixel corresponding to a single sensor element of the sensor array. Levels from the sensor elements which have been thresholded to predetermined threshold values are fed-back to the LCD for image display and processing. The LCD image may be moved in a pixel increment by control circuitry to implement morphological image processing.

Abstract: Bands of predetectors (92) detect the approach of lines of glyphs (12, 14) within an image being scanned. Linear lines or arrays of glyph detectors (116, 118, 120) are sampled in accordance with the detected approach of lines of glyphs. Each detector array includes a plurality of analog glyph detectors (20, 50) which respond to the presence of glyphs with a characteristic analog output. Preferably, the glyph detectors generate a corresponding analog output of a first polarity or other characteristic in response to glyphs of a first orientation and an output of a second polarity or characteristic in response to glyphs of a second orientation. The analog signals which are characteristic of the detection of a glyph are converted into binary 1's and 0's in accordance with the polarity or other characteristic of the signals. In this manner, glyphs are detected by analog detectors and the information encoded in the glyphs is directly output as a binary signal without computer analysis of the image.

Abstract: A compact neural network architecture is trainable to sense and classify an optical image directly projected onto it. The system is based upon the combination of a two-dimensional amorphous silicon photoconductor array and a liquid-crystal spatial light modulator. Appropriate filtering of the incident optical image upon capture is incorporated into the net work training rules, through a modification of the standard backpropagation training algorithm. Training of the network on two image classification problems is described: the recognition of handprinted digits, and facial recognition. The network, once trained is capable of standalone operation, sensing an incident image and outputting a final classification signal in real time.

Abstract: A method of ejecting a droplet of a fluid from a surface of the fluid includes the step of generating an acoustic wave to eject the droplet from the fluid surface. The acoustic wave is shaped into an optimal toneburst such that the droplet is ejected substantially in a direction of acoustic wave propagation substantially independent of an orientation of the fluid surface.

Abstract: A detector array method and apparatus for real time in-situ color control in printers and copiers includes an array for performing a linear matrix transformation on color patch information generated by a printer or copier. A light sensor array detects color components from a series of color test patches and performs a predetermined matrix transformation on the color information to produce a set of control signals for feedback to the printer or copier. In another embodiment, the light sensor array is extended to produce a fully analog neural network processor which is capable of arbitrary mappings of the color information into control signals for use by the printer or copier apparatus. The system is fully programmable, adaptive and, in one embodiment, trainable using backpropagation or other techniques.