Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.

Abstract: An extracorporeal gas exchange device includes a housing, a rigid shaft rotatable within the housing, a plurality of agitation mechanisms positioned on the rigid shaft, and a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between fluid flowing within the housing and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers are positioned radially outward from the plurality of agitation mechanisms. The rotational speed of the rigid shaft is adjustable independent of the flow rate of fluid through the housing.

Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.

Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.

Abstract: An extracorporeal gas exchange device includes a housing, a rigid shaft rotatable within the housing, a plurality of agitation mechanisms positioned on the rigid shaft, and a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between fluid flowing within the housing and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers are positioned radially outward from the plurality of agitation mechanisms. The rotational speed of the rigid shaft is adjustable independent of the flow rate of fluid through the housing.

Abstract: Firearm rests for hunting stands are provided. A firearm rest includes a first arm and a second arm. The second arm is spaced apart from the first arm along a lateral direction. The first arm and second arm each include a body extending between a first end and a second end, the body including a fixed portion and a rotational portion that is rotational between an extended position and a retracted position. The firearm rest further includes a cross-beam extending generally along the lateral direction between the first arm and the second arm. The cross-beam is coupled to the first arm at the first end and coupled to the second arm at the first end. The cross-beam has a position along a vertical direction in the extended position that is above a position of the cross-beam along the vertical direction in the retracted position.

Abstract: Firearm rests for hunting stands are provided. A firearm rest includes a first arm and a second arm. The second arm is spaced apart from the first arm along a lateral direction. The first arm and second arm each include a body extending between a first end and a second end, the body including a fixed portion and a rotational portion that is rotational between an extended position and a retracted position. The firearm rest further includes a cross-beam extending generally along the lateral direction between the first arm and the second arm. The cross-beam is coupled to the first arm at the first end and coupled to the second arm at the first end. The cross-beam has a position along a vertical direction in the extended position that is above a position of the cross-beam along the vertical direction in the retracted position.

Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.

Abstract: An approach is provided for supporting telephony services over a data network. A communication network establishes a voice session from a calling station to a called station associated with a user. A service platform, in communication with the communication network, obtains Caller ID information corresponding to the voice session, and determines an instant communication client of the user. The Caller ID information is transmitted over the data network to the instant communication client for display of the Caller ID information.

Abstract: An ion source able to ionize both liquid and gaseous vapors from interfaced liquid separation techniques and a solids/liquid atmospheric pressure (AP) probe. The liquid effluents are ionized by electrospray ionization, photoionization or atmospheric pressure chemical ionization and the vapors released from a probe device placed in a heated gas stream in the AP source are ionized by a corona or Townsend electrical discharge or photoionization. The source has the ability to ionize compounds from both liquid and solid sources, which facilitates ionization of volatile and semivolatile compounds by applying heat from a gas stream as well as highly non-volatile compounds infused by electrospray or separated by liquid chromatography or capillary electrophoresis.

Abstract: An approach is provided for supporting telephony services over a data network. A communication network establishes a voice session from a calling station to a called station associated with a user. A service platform, in communication with the communication network, obtains Caller ID information corresponding to the voice session, and determines an instant communication client of the user. The Caller ID information is transmitted over the data network to the instant communication client for display of the Caller ID information.

Abstract: An approach is provided for supporting telephony services over a data network. A communication network establishes a voice session from a calling station to a called station associated with a user. A service platform, in communication with the communication network, obtains Caller ID information corresponding to the voice session, and determines an instant communication client of the user. The Caller ID information is transmitted over the data network to the instant communication client for display of the Caller ID information.

Abstract: An ion source able to ionize both liquid and gaseous vapors from interfaced liquid separation techniques and a solids/liquid atmospheric pressure (AP) probe. The liquid effluents are ionized by electrospray ionization, photoionization or atmospheric pressure chemical ionization and the vapors released from a probe device placed in a heated gas stream in the AP source are ionized by a corona or Townsend electrical discharge or photoionization. The source has the ability to ionize compounds from both liquid and solid sources, which facilitates ionization of volatile and semivolatile compounds by applying heat from a gas stream as well as highly non-volatile compounds infused by electrospray or separated by liquid chromatography or capillary electrophoresis.

Abstract: An atmospheric pressure (AP) mass spectrometry ion source able to ionize analytes in liquid effluents from interfaced liquid separation techniques and from individual containers, as in microtiter plates, by direct introduction of the analyte into the ion source using a moving ribbon, wire, or belt with vaporization of the analyte and subsequent ionization using an electric discharge or photoionization. The AP source may also incorporate atmospheric pressure chemical ionization (APCI), photoionization (APPI) and/or electrospray ionization (ESI), techniques that are commercially available. The source facilitates ionization of volatile and semivolatile compounds by applying heat from a gas stream to vaporize analyte entering the ionization region on a moving transport device. Solvent removal prior to sample entering the ionization region enables ionization of a wider range of compounds than liquid introduction APCI or APPI.

Abstract: Embodiments of a module and backplane are presented herein.

Abstract: An approach is provided for supporting telephony services over a data network. The approach aggregate message waiting indication information from one or more voice mail systems for notifying a user of the presence of a voice mail message resident on any one of the voice mail systems. According to a user profile, a notification message is transmitted over the data network to one or more instant communication clients based upon the aggregated message waiting indication information, wherein the notification message specifies the presence of the voice mail message.

Abstract: Embodiments of a module and backplane are presented herein.

Abstract: Embodiments of a module and backplane are presented herein.