Abstract: The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.

Abstract: A raised bed planter box includes a first corner post, a second corner post, a third corner post, and a fourth corner post. Each of the corner posts defines a first open-ended channel and a second open-ended channel positioned at an angle of about 90 degrees relative to the first open-ended channel. A first sidewall extends between the first open-ended channel of the first corner post and the first open-ended channel of the second corner post. A first end wall extends between the second open-ended channel of the second corner post and the second open-ended channel of the third corner post. A second sidewall extends between the first open-ended channel of the third corner post and the first open-ended channel of the fourth corner post. A second end wall extends between the second open-ended channel of the fourth corner post and the second open-ended channel of the first corner post.