Patents by Inventor Richard Gomer
Richard Gomer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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COMPOSITIONS ASSOCIATED WITH AND METHODS OF MANAGING NEUTROPHIL MOVEMENT USING SERUM AMYLOID P (SAP)
Publication number: 20150087576Abstract: The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a Serum Amyloid P (SAP) composition in an amount and for a time sufficient to suppress neutrophil movement into the body region. In particular, it relates to a method of reducing the number of neutrophils in a body region suffering from an acute injury or from a chronic or long-term disease. Further, the disclosure relates to a method of increasing the number of neutrophils in a body region by administering an anti-SAP antibody or material able to bind SAP. The disclosure further relates to compositions usable with these methods.Type: ApplicationFiled: December 13, 2012Publication date: March 26, 2015Inventors: Richard Gomer, Anu S. Maharjan, David J. Roife -
Publication number: 20130039897Abstract: The disclosure relates to compositions including dipeptidyl peptidase-IV (DPPIV) as well as compositions including an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium autocrine proliferation repressor A (AprA) region. The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a DPPIV composition to the body region in an amount and for a time sufficient to suppress neutrophil movement into the body region or enhancing neutrophil movement out of the body region. In particular, it relates to a method of reducing the number of neutrophils in a body region suffering from an acute injury or from a chronic or long-term disease. Further, the disclosure relates to a method of increasing the number of neutrophils in a body region by administering an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium AprA region.Type: ApplicationFiled: August 10, 2012Publication date: February 14, 2013Applicant: The Texas A&M University SystemInventors: Richard Gomer, Jonathan Phillips, Sarah Herlihy, Anu S. Maharjan, Darrell Pilling
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Patent number: 8187608Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.Type: GrantFiled: September 23, 2011Date of Patent: May 29, 2012Assignee: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Patent number: 8187599Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.Type: GrantFiled: September 2, 2011Date of Patent: May 29, 2012Assignee: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Publication number: 20120009146Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.Type: ApplicationFiled: September 23, 2011Publication date: January 12, 2012Applicant: WILLIAM MARSH RICE UNIVERSITYInventors: Richard Gomer, Darrell Pilling
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Publication number: 20110311554Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.Type: ApplicationFiled: September 2, 2011Publication date: December 22, 2011Inventors: Richard Gomer, Darrell Pilling
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Patent number: 8057802Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.Type: GrantFiled: December 24, 2008Date of Patent: November 15, 2011Assignee: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Patent number: 8012472Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.Type: GrantFiled: September 27, 2006Date of Patent: September 6, 2011Assignee: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Patent number: 7935682Abstract: The present invention relates to the ability of SAP to suppress the differentiation of monocytes into fibrocytes. It also relates to the ability of IL-4 and IL-3 to enhance the differentiation of monocytes into fibrocytes. Methods and compositions for binding SAP, decreasing SAP levels and suppressing SAP activity are provided. Methods of using, inter alia, CPHPC, the 4,6-pyruvate acetyl of beta-D-galactopyranose, ethanolamines, high EEO agarose, IL-4, and IL-13, and anti-SAP antibodies and fragments thereof to increase monocyte differentiation into fibrocytes are provided. These methods are useful in a variety of applications, including wound healing. Wound dressings are also provided. Finally, the invention may include assays for detecting the ability of various agents to modulate monocyte differentiation into fibrocytes and to detect monocyte defects.Type: GrantFiled: June 22, 2005Date of Patent: May 3, 2011Assignee: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Publication number: 20100221208Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.Type: ApplicationFiled: December 24, 2008Publication date: September 2, 2010Applicant: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Patent number: 7763256Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.Type: GrantFiled: September 27, 2006Date of Patent: July 27, 2010Assignee: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Patent number: 7666432Abstract: The present invention relates to the ability of SAP to suppress the differentiation of monocytes into fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress the differentiation of monocytes into fibrocytes. Methods and compositions for suppressing differentiation of monocytes into fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate monocyte differentiation into fibrocytes and to detect monocyte defects. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.Type: GrantFiled: June 22, 2005Date of Patent: February 23, 2010Assignee: William Marsh Rice UniversityInventors: Richard Gomer, Darrell Pilling
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Publication number: 20070191973Abstract: This invention allows users to set different alarm conditions and data storage criteria for multiple data points based on the operating modes (states) of their machinery. The users will also be able to selectively view the collected data based on the machinery states.Type: ApplicationFiled: February 10, 2006Publication date: August 16, 2007Applicant: General Electric CompanyInventors: Bryan Holzbauer, Ken Ceglia, Wayne Johnson, Scott Williams, Richard Gomer
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Publication number: 20070065866Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.Type: ApplicationFiled: September 27, 2006Publication date: March 22, 2007Inventors: Richard Gomer, Darrell Pilling
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Publication number: 20070065368Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.Type: ApplicationFiled: September 27, 2006Publication date: March 22, 2007Inventors: Richard Gomer, Darrell Pilling
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Publication number: 20060106501Abstract: A method of generating NOx curves over a range of load points includes obtaining current measurements from a respective sensor and validating the current measurements. A plurality of input curves are generated using predefined inputs for each load point. The plurality of input curves include a first set point curve and a second set point curve, where the second setpoint curve includes the first setpoint curve offset with the current measurements. A plurality of NOx curves are generated including a design curve, an adjusted design curve, and a NOx generation curve created by a neural model. The second setpoint curve is passed through the neural model to derive the NOx generation curve. After validating the NOx generation curve and adjusted design curve, one of the plurality of NOx curves is outputted.Type: ApplicationFiled: November 12, 2004Publication date: May 18, 2006Applicant: GENERAL ELECTRIC COMPANYInventors: Richard Gomer, Bryan Holzbauer, Scott Williams, Shane Jenkins, James Maxson, Stephen Kwan
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Publication number: 20060106740Abstract: Methods, apparatus, and articles of manufacture such as software media for creating projected power production data are disclosed. The method may comprise storing historical heat rate data and historical process information for at least one power generation unit in a historical heat rate database. The method may also comprise retrieving the historical heat rate data from the database for a selected time interval and correcting the historical rate data using correction factors which may be based on differences between the historical process information and projected process information; and creating a projected cost or a projected price for a future time interval based on the retrieved historical heat rate data.Type: ApplicationFiled: November 12, 2004Publication date: May 18, 2006Applicant: GENERAL ELECTRIC COMPANYInventors: Bryan Holzbauer, Scott Williams, James Maxson, Shane Jenkins, Stephen Kwan, Richard Gomer
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Publication number: 20060107228Abstract: A method, system, and article of manufacture such as software media is disclosed for creating a text input file and a text output file according to the requirements of a power generation party.Type: ApplicationFiled: November 12, 2004Publication date: May 18, 2006Applicant: GENERAL ELECTRIC COMPANYInventors: Bryan Holzbauer, Scott Williams, James Maxson, Shane Jenkins, Richard Gomer
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Publication number: 20060106737Abstract: A method of generating emission curves over a range of load points includes obtaining current measurements from a respective sensor. The current measurements are validated and a plurality of emission curves using predefined inputs for each load point are generated. The plurality of emission curves includes an emission design curve and a corresponding real time incremental emission curve. Each corresponding real time incremental emission curve and emission design curve are validated to generate a validated emission curve. An incremental emission cost curve using each validated emission curve for each type of emission is generated. Each incremental emission cost curve is summed if there is more than one incremental emission cost curve.Type: ApplicationFiled: November 12, 2004Publication date: May 18, 2006Applicant: GENERAL ELECTRIC COMPANYInventors: Richard Gomer, Bryan Holzbauer, Scott Williams, Shane Jenkins, James Maxson, Stephen Kwan
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Publication number: 20060106739Abstract: Methods, apparatus, and articles of manufacture such as software media for creating projected power production data are described herein. The method may comprise storing historical heat rate data for at least one power generation unit in a historical heat rate database. The method may also comprise retrieving the historical heat rate data from the database for a selected time interval and creating a projected cost curve and/or a projected price curve for a future time interval based on the historical heat rate data.Type: ApplicationFiled: November 12, 2004Publication date: May 18, 2006Applicant: GENERAL ELECTRIC COMPANYInventors: Bryan Holzbauer, Scott Williams, James Maxson, Shane Jenkins, Stephen Kwan, Richard Gomer