Patents by Inventor Richard Gomer

Richard Gomer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150087576
    Abstract: The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a Serum Amyloid P (SAP) composition in an amount and for a time sufficient to suppress neutrophil movement into the body region. In particular, it relates to a method of reducing the number of neutrophils in a body region suffering from an acute injury or from a chronic or long-term disease. Further, the disclosure relates to a method of increasing the number of neutrophils in a body region by administering an anti-SAP antibody or material able to bind SAP. The disclosure further relates to compositions usable with these methods.
    Type: Application
    Filed: December 13, 2012
    Publication date: March 26, 2015
    Inventors: Richard Gomer, Anu S. Maharjan, David J. Roife
  • Publication number: 20130039897
    Abstract: The disclosure relates to compositions including dipeptidyl peptidase-IV (DPPIV) as well as compositions including an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium autocrine proliferation repressor A (AprA) region. The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a DPPIV composition to the body region in an amount and for a time sufficient to suppress neutrophil movement into the body region or enhancing neutrophil movement out of the body region. In particular, it relates to a method of reducing the number of neutrophils in a body region suffering from an acute injury or from a chronic or long-term disease. Further, the disclosure relates to a method of increasing the number of neutrophils in a body region by administering an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium AprA region.
    Type: Application
    Filed: August 10, 2012
    Publication date: February 14, 2013
    Applicant: The Texas A&M University System
    Inventors: Richard Gomer, Jonathan Phillips, Sarah Herlihy, Anu S. Maharjan, Darrell Pilling
  • Patent number: 8187608
    Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: May 29, 2012
    Assignee: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Patent number: 8187599
    Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: May 29, 2012
    Assignee: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Publication number: 20120009146
    Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 12, 2012
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Richard Gomer, Darrell Pilling
  • Publication number: 20110311554
    Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.
    Type: Application
    Filed: September 2, 2011
    Publication date: December 22, 2011
    Inventors: Richard Gomer, Darrell Pilling
  • Patent number: 8057802
    Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: November 15, 2011
    Assignee: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Patent number: 8012472
    Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: September 6, 2011
    Assignee: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Patent number: 7935682
    Abstract: The present invention relates to the ability of SAP to suppress the differentiation of monocytes into fibrocytes. It also relates to the ability of IL-4 and IL-3 to enhance the differentiation of monocytes into fibrocytes. Methods and compositions for binding SAP, decreasing SAP levels and suppressing SAP activity are provided. Methods of using, inter alia, CPHPC, the 4,6-pyruvate acetyl of beta-D-galactopyranose, ethanolamines, high EEO agarose, IL-4, and IL-13, and anti-SAP antibodies and fragments thereof to increase monocyte differentiation into fibrocytes are provided. These methods are useful in a variety of applications, including wound healing. Wound dressings are also provided. Finally, the invention may include assays for detecting the ability of various agents to modulate monocyte differentiation into fibrocytes and to detect monocyte defects.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: May 3, 2011
    Assignee: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Publication number: 20100221208
    Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.
    Type: Application
    Filed: December 24, 2008
    Publication date: September 2, 2010
    Applicant: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Patent number: 7763256
    Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: July 27, 2010
    Assignee: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Patent number: 7666432
    Abstract: The present invention relates to the ability of SAP to suppress the differentiation of monocytes into fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress the differentiation of monocytes into fibrocytes. Methods and compositions for suppressing differentiation of monocytes into fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate monocyte differentiation into fibrocytes and to detect monocyte defects. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: February 23, 2010
    Assignee: William Marsh Rice University
    Inventors: Richard Gomer, Darrell Pilling
  • Publication number: 20070191973
    Abstract: This invention allows users to set different alarm conditions and data storage criteria for multiple data points based on the operating modes (states) of their machinery. The users will also be able to selectively view the collected data based on the machinery states.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 16, 2007
    Applicant: General Electric Company
    Inventors: Bryan Holzbauer, Ken Ceglia, Wayne Johnson, Scott Williams, Richard Gomer
  • Publication number: 20070065866
    Abstract: The present invention relates to the ability of anti-Fc?R antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth, pancreas, gastrointestinal tract, brain, breast, bone marrow, bone, genitourinary system, a tumor, or a wound.
    Type: Application
    Filed: September 27, 2006
    Publication date: March 22, 2007
    Inventors: Richard Gomer, Darrell Pilling
  • Publication number: 20070065368
    Abstract: The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate differentiation into fibrocytes. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.
    Type: Application
    Filed: September 27, 2006
    Publication date: March 22, 2007
    Inventors: Richard Gomer, Darrell Pilling
  • Publication number: 20060106501
    Abstract: A method of generating NOx curves over a range of load points includes obtaining current measurements from a respective sensor and validating the current measurements. A plurality of input curves are generated using predefined inputs for each load point. The plurality of input curves include a first set point curve and a second set point curve, where the second setpoint curve includes the first setpoint curve offset with the current measurements. A plurality of NOx curves are generated including a design curve, an adjusted design curve, and a NOx generation curve created by a neural model. The second setpoint curve is passed through the neural model to derive the NOx generation curve. After validating the NOx generation curve and adjusted design curve, one of the plurality of NOx curves is outputted.
    Type: Application
    Filed: November 12, 2004
    Publication date: May 18, 2006
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Richard Gomer, Bryan Holzbauer, Scott Williams, Shane Jenkins, James Maxson, Stephen Kwan
  • Publication number: 20060106740
    Abstract: Methods, apparatus, and articles of manufacture such as software media for creating projected power production data are disclosed. The method may comprise storing historical heat rate data and historical process information for at least one power generation unit in a historical heat rate database. The method may also comprise retrieving the historical heat rate data from the database for a selected time interval and correcting the historical rate data using correction factors which may be based on differences between the historical process information and projected process information; and creating a projected cost or a projected price for a future time interval based on the retrieved historical heat rate data.
    Type: Application
    Filed: November 12, 2004
    Publication date: May 18, 2006
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Bryan Holzbauer, Scott Williams, James Maxson, Shane Jenkins, Stephen Kwan, Richard Gomer
  • Publication number: 20060107228
    Abstract: A method, system, and article of manufacture such as software media is disclosed for creating a text input file and a text output file according to the requirements of a power generation party.
    Type: Application
    Filed: November 12, 2004
    Publication date: May 18, 2006
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Bryan Holzbauer, Scott Williams, James Maxson, Shane Jenkins, Richard Gomer
  • Publication number: 20060106737
    Abstract: A method of generating emission curves over a range of load points includes obtaining current measurements from a respective sensor. The current measurements are validated and a plurality of emission curves using predefined inputs for each load point are generated. The plurality of emission curves includes an emission design curve and a corresponding real time incremental emission curve. Each corresponding real time incremental emission curve and emission design curve are validated to generate a validated emission curve. An incremental emission cost curve using each validated emission curve for each type of emission is generated. Each incremental emission cost curve is summed if there is more than one incremental emission cost curve.
    Type: Application
    Filed: November 12, 2004
    Publication date: May 18, 2006
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Richard Gomer, Bryan Holzbauer, Scott Williams, Shane Jenkins, James Maxson, Stephen Kwan
  • Publication number: 20060106739
    Abstract: Methods, apparatus, and articles of manufacture such as software media for creating projected power production data are described herein. The method may comprise storing historical heat rate data for at least one power generation unit in a historical heat rate database. The method may also comprise retrieving the historical heat rate data from the database for a selected time interval and creating a projected cost curve and/or a projected price curve for a future time interval based on the historical heat rate data.
    Type: Application
    Filed: November 12, 2004
    Publication date: May 18, 2006
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Bryan Holzbauer, Scott Williams, James Maxson, Shane Jenkins, Stephen Kwan, Richard Gomer