Abstract: A composition configured for oral use is provided, the composition including a filler in an amount of at least 20% by weight, based on the total weight of the composition, and at least one active ingredient including one or more botanical materials, stimulants, amino acids, vitamins, antioxidants, cannabinoids, pharmaceutical agents, or a combination thereof. The composition further includes a salt and at least one sweetener. The composition has a moisture content of at least about 40% by weight, based on the total weight of the composition.

Abstract: A method for allowing user configuration of an endpoint for consuming a business object includes: loading a definition of the business object, the definition having properties and methods; mapping the definition to endpoint-supported protocols; and allowing user configuration of the endpoint based upon at least one of: (i) services configuration, (ii) protocol configuration, or (iii) managed configuration.

Abstract: A method for allowing user configuration of an endpoint for consuming a business object includes: loading a definition of the business object, the definition having properties and methods; mapping the definition to endpoint-supported protocols; and allowing user configuration of the endpoint based upon at least one of: (i) services configuration, (ii) protocol configuration, or (iii) managed configuration.

Abstract: The system and method disclosed herein is a dynamic endpoint generator that enables a client device or application to consume business objects. The business objects are dynamic business objects whose definitions can be changed by either adding or removing data or actions without the need to involve technical or development resources to reconfigure or recompile the actual objects. The endpoint generator provides updated endpoint information automatically without the need for manual generation of endpoint or contract data. If a business object is modified or newly added, the endpoint generator is automatically notified and publishes information about the modified or newly added object. The client device that is accessing the business object is notified about the modified or newly added object. Or, an endpoint is generated when a client device requests a business object.

Abstract: Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses.

Abstract: The system and method disclosed herein is a dynamic endpoint generator that enables a client device or application to consume business objects. The business objects are dynamic business objects whose definitions can be changed by either adding or removing data or actions without the need to involve technical or development resources to reconfigure or recompile the actual objects. The endpoint generator provides updated endpoint information automatically without the need for manual generation of endpoint or contract data. If a business object is modified or newly added, the endpoint generator is automatically notified and publishes information about the modified or newly added object. The client device that is accessing the business object is notified about the modified or newly added object. Or, an endpoint is generated when a client device requests a business object.

Abstract: Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses.

Abstract: The present invention features compounds of Formula (I) and (Ia), pharmaceutical compositions and use in the treatment of viral disease:

Abstract: Novel antiviral compounds of Formula (I): wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or —C5-9cycloalkyl, each of which may be optionally substituted; R2 represents substituted phenyl, or —(CH2)nC5-7cycloalkyl optionally substituted on the cycloalkyl; R3 represents heterocyclyl or heteroaryl; optionally substituted phenyl or optionally substituted —C1-6alkyl; R4 represents hydrogen; and salts, solvates and esters thereof processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:

Abstract: A laser cutting system including a laser cutting device, a sheet supporting and positioning grid, sheet loading members, and an intermediate sheet transfer device. A laser device is able to cut a metal sheet while the sheet is supported by a grid. The grid is movable on a laser cutting table. The sheet loading members comprise movable members able to support a metal sheet during loading of the sheet onto the grid. The movable members are enabled to pass through the grid to receive and support a sheet. An intermediate sheet transfer device is positioned outside of the grid and intermediate a sheet delivery cart and the grid. The intermediate sheet transfer device enables an easier transfer of a metal sheet from a sheet delivery cart onto the movable members. The intermediate transfer device may also include movable members. The movable members may include rotatable balls.

Abstract: A flushable urine conductive appliance comprising a flexible layered sheet adapted to be folded for positioning between the legs of a female to direct urine to an appropriate receptacle including at least an inner layer formed from a fibrous or non-fibrous sheet adapted for rapid disintegration of structural integrity in contact with water, and intermediate layer formed from at least one continuous film of water-soluble polymer, and an outer layer formed from at least one fibrous or non-fibrous sheet and capable of rapid disintegration of structural integrity when in contact with water.