Patents by Inventor Richard H. Ffrench-Constant

Richard H. Ffrench-Constant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Infection Factor Assay
    Publication number: 20120258128
    Abstract: There is provided a method of selecting an anti-macrophage micro-organism comprising an anti-macrophage factor, the method comprising the steps of: a) obtaining an assay micro-organism and preparing a sample thereof; b) lysing the assay micro-organism cells contained in the sample from (a) to form a lysate fluid; c) contacting a sample of macrophage cells with the lysate fluid from step (b); d) determining the macrophage cell viability and comparing the viability to the viability of macrophage cells in a control macrophage sample; and e) selecting the micro-organism as an anti-macrophage micro-organism if the viability is reduced by at least 10%. The anti-macrophage factors identifiable by methods according to the invention can be used in the formulation of vaccines and other therapies against disorders caused by the anti-macrophage micro-organism.
    Type: Application
    Filed: April 3, 2012
    Publication date: October 11, 2012
    Applicant: UNIVERSITY OF EXETER
    Inventors: Andrea J. Dowling, Richard H. Ffrench-Constant
  • DNA sequences from tcd genomic region of
    Patent number: 7777100
    Abstract: Nucleotide sequences for seven genes, tccC4, tcdA3, tcdA2, tcdB2, tccC3, tcdA4, tccC5, from the tcd genomic region of Photorhabdus luminescens W-14, are useful in heterologous expression of orally active insect toxins.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: August 17, 2010
    Inventors: Richard H. ffrench-Constant, Nicholas R. Waterfield
  • Nucleic acid encoding an insecticidal protein toxin from photorhabdus
    Patent number: 7569748
    Abstract: Proteins from the genus Photorhabdus are toxic to insects upon exposure. Photorhabdus luminescens (formerly Xenorhabdus luminescens) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus Heterohabditis. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: August 4, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jerald C. Ensign, David J. Bowen, James Petell, Raymond Fatig, Sue Schoonover, Richard H. Ffrench-Constant, Thomas A. Rocheleau, Michael B. Blackburn, Timothy D. Hey, Donald J. Merlo, Gregory L Orr, Jean L. Roberts, James A. Strickland, Lining Guo, Todd A. Ciche, Kitisri Sukhapinda
  • DNA sequences from tcd genomic region of photorhabdus luminescens
    Publication number: 20080168588
    Abstract: Nucleotide sequences for seven genes, tccC4, tcdA3, tcdA2, tcdB2, tccC3, tcdA4, tccC5, from the tcd genomic region of Photorhabdus luminescens W-14, are useful in heterologous expression of orally active insect toxins.
    Type: Application
    Filed: July 31, 2007
    Publication date: July 10, 2008
    Inventors: Richard H. ffrench-Constant, Nicholas R. Waterfield
  • tcdB2 protein from W-14
    Patent number: 7268275
    Abstract: TcdB2, a protein from Photorhabdus luminescens W-14, and nucleotide sequences encoding TcdB2, are useful for enhancing expression of orally active Photorhabdus luminescens insecticidal toxins in heterologous organisms.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: September 11, 2007
    Assignee: University of Bath
    Inventors: Richard H. ffrench-Constant, Nicholas R. Waterfield
  • DNA Sequences from
    Patent number: 7161062
    Abstract: Nucleotide sequences for two genes, tcdB and tccC2, from the tcd genomic region of Photorhabdus luminescens W-14 are useful in heterologous expression of orally active insect toxins.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: January 9, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Richard H. Ffrench-Constant, David J. Bowen, Thomas A. Rocheleau, Nicholas R. Waterfield
  • DNA sequences from Tcd genomic region of photorhabdus luminescens
    Publication number: 20040103455
    Abstract: Nucleotide sequences for seven genes, tccC4, tcdA3, tcdA2, tcdB2, tccC3, tcdA4, tccC5, from the tcd genomic region of Photorhabdus luminescens W-14, are useful in heterologous expression of orally active insect toxins.
    Type: Application
    Filed: November 12, 2003
    Publication date: May 27, 2004
    Inventors: Richard H. Ffrench-Constant, Nicholas R. Waterfield
  • Insecticidal protein toxins from Photorhabdus
    Publication number: 20030207806
    Abstract: Proteins from the genus Photorhabdus are toxic to insects upon exposure. Photorhabdus luminescens (formerly Xenorhabdus luminescens) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus Heterorhabditis. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.
    Type: Application
    Filed: October 2, 2002
    Publication date: November 6, 2003
    Inventors: Jerald C. Ensign, David J. Bowen, James Petell, Raymond Fatig, Sue Schoonover, Richard H. Ffrench-Constant, Thomas A. Rocheleau, Michael B. Blackburn, Timothy D. Hey, Donald J. Merlo, Gregory L. Orr, Jean L. Roberts, James A. Strickland, Lining Guo, Todd A. Ciche, Kitisri Sukhapinda
  • DNA sequences from photorhabdus luminescens
    Patent number: 6639129
    Abstract: Nucleotide sequences for two genes, tcdB and tccC2, from the tcd genomic region of Photorhabdus luminescens W-14 are useful in heterologous expression of orally active insect toxins.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: October 28, 2003
    Assignees: Wisconsin Alumni Research Foundation, University of Bath
    Inventors: Richard H. ffrench-Constant, David J. Bowen, Thomas A. Rocheleau, Nicholas R. Waterfield
  • Insecticidal protein toxins from Photorhabdus
    Patent number: 6528484
    Abstract: Proteins from the genus Photorhabdus are toxic to insects upon exposure. Photorhabdus luminescens (formerly Xenorhabdus luminescens) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus Heterorhabditis. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: March 4, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jerald C. Ensign, David J. Bowen, James Petell, Raymond Fatig, Sue Schoonover, Richard H. ffrench-Constant, Thomas A. Rocheleau, Michael B. Blackburn, Timothy D. Hey, Donald J. Merlo, Gregory L. Orr, Jean L. Roberts, James A. Strickland, Lining Guo, Todd A. Ciche, Kitisri Sukhapinda
  • Insecticidal protein toxins from xenorhabdus
    Publication number: 20020147148
    Abstract: Proteins from the genus Xenorhabdus are toxic to insects upon oral exposure. These protein toxins can be applied to insect larvae food and plants for insect control.
    Type: Application
    Filed: February 19, 2002
    Publication date: October 10, 2002
    Inventors: Jerald C. Ensign, David J. Bowen, Jennifer L. Tenor, Todd A. Ciche, James K. Petell, James A. Strickland, Gregory L. Orr, Raymond O. Fatig, Scott B. Bintrim, Richard H. Ffrench-Constant
  • DNA sequences from photorhabdus luminescens
    Publication number: 20020078478
    Abstract: Nucleotide sequences for two genes, tcdB and tccC2, from the tcd genomic region of Photorhabdus luminescens W-14 are useful in heterologous expression of orally active insect toxins.
    Type: Application
    Filed: March 26, 2001
    Publication date: June 20, 2002
    Inventors: Richard H. Ffrench-Constant, David Bowen, Thomas A. Rocheleau, Nicholas R. Waterfield
  • Insecticidal protein toxins from Xenorhabdus
    Patent number: 6379946
    Abstract: Proteins from the genus Xenorhabdus are toxic to insects upon oral exposure. These protein toxins can be applied to insect larvae food and plants for insect control.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: April 30, 2002
    Assignee: Wisconsin Alumn Research Foundation
    Inventors: Jerald C. Ensign, David J. Bowen, Jennifer L. Tenor, James K. Petell, Gregory L. Orr, Scott B. Bintrim, Todd A. Ciche, James A. Strickland, Raymond O. Fatig, Richard H. Ffrench-Constant
  • Insecticidal protein toxins from xenorhabdus
    Patent number: 6048838
    Abstract: Proteins from the genus Xenorhabdus are toxic to insects upon oral exposure. These protein toxins can be applied to insect larvae food and plants for insect control.
    Type: Grant
    Filed: May 4, 1998
    Date of Patent: April 11, 2000
    Assignee: Dow AgroSciences LLC
    Inventors: Jerald C. Ensign, David J. Bowen, Jennifer L. Tenor, Todd A. Ciche, James K. Petell, James A. Strickland, Gregory L. Orr, Raymond O. Fatig, Scott B. Bintrim, Richard H. Ffrench-Constant
  • Drug and pesticide screening
    Patent number: 6008046
    Abstract: The present invention relates to methods and reagents for drug and pesticide screening. Screening methods are disclosed employing normal and mutant receptors, allowing for the testing of large numbers of potentially useful compounds.
    Type: Grant
    Filed: June 2, 1993
    Date of Patent: December 28, 1999
    Assignee: Ophidian Pharmaceuticals, Inc.
    Inventors: Richard H. Ffrench-Constant, Meyer B. Jackson