Patents by Inventor Richard Houghten

Richard Houghten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH-AFFINITY SMALL MOLECULE FORMYLPEPTIDE RECEPTOR LIGANDS FROM SCREENING OF COMBINATORIAL MIXTURE-BASED LIBRARIES
    Publication number: 20160320402
    Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
    Type: Application
    Filed: February 2, 2016
    Publication date: November 3, 2016
    Inventors: Bruce S. Edwards, Larry A. Sklar, Clemencia Pinilla, Richard A. Houghten, Jon R. Appel, Marc A. Giulianotti, Jose Medina-Franco
  • High-affinity small molecule formylpeptide receptor ligands from screening of combinatorial mixture-based libraries
    Patent number: 9310364
    Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: April 12, 2016
    Assignees: STC.UNM, TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
    Inventors: Bruce S. Edwards, Larry A. Sklar, Clemencia Pinilla, Richard A. Houghten, Jon R. Appel, Marc A. Giulianotti, Jose Medina-Franco
  • Methods and compositions for treating pain
    Patent number: 9233159
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 12, 2016
    Assignees: MannKind Corporation, Torrey Pines Institute for Molecular Studies
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • COMPOUNDS AND METHODS OF TREATING NEUROLOGICAL DISORDERS
    Publication number: 20150315179
    Abstract: Embodiments of the present disclosure provide for compositions including a compound, pharmaceutical compositions including the compound, methods of treatment of a disease or related condition (e.g., neurological disease on condition), methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Application
    Filed: April 30, 2015
    Publication date: November 5, 2015
    Inventors: Madepalli K. Lakshmana, Adel Nefzi, Richard Houghten, Dmitriy Minond
  • METHODS AND COMPOSITIONS FOR TREATING PAIN
    Publication number: 20150150980
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Application
    Filed: February 13, 2015
    Publication date: June 4, 2015
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • METHODS AND COMPOSITIONS FOR TREATING PAIN
    Publication number: 20140302151
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 9, 2014
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • Melanin-concentrating hormone receptor antagonists and methods of use
    Patent number: 8372848
    Abstract: This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: February 12, 2013
    Assignees: Mixture Sciences, Inc., The Regents of the University of California
    Inventors: Richard A. Houghten, Colette Dooley, Adel Nefzi, Zhiwei Wang, Oliver Civelli, Hiroshi Nagasaki
  • Conjugates of membrane translocating agents and pharmaceutically active agents
    Patent number: 8017727
    Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: September 13, 2011
    Assignee: Merrion Research III Limited
    Inventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
  • METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE
    Publication number: 20110183358
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: March 17, 2006
    Publication date: July 28, 2011
    Applicants: THE BURNHAM INSTITUTE, TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Kate Welsh, Clemencia Pinilla
  • CONJUGATES OF MEMBRANE TRANSLOCATING AGENTS AND PHARMACEUTICALLY ACTIVE AGENTS
    Publication number: 20100168381
    Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.
    Type: Application
    Filed: December 23, 2009
    Publication date: July 1, 2010
    Inventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
  • Conjugates of membrane translocating agents and pharmaceutically active agents
    Patent number: 7638599
    Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: December 29, 2009
    Assignee: Merrion Research III Limited
    Inventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
  • Peptide mixtures with immunomodulatory activity
    Publication number: 20090214580
    Abstract: The present invention is related to complex peptide mixtures with immunomodulatory effects and methods for their use. The invention is further directed toward treatments of diseases through the modulation of the immune system with complex peptide mixtures. The invention is also directed to methods for improving the characteristics of complex peptide mixtures.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 27, 2009
    Inventors: Richard A. Houghten, Clemencia Pinilla, Roland Martin, Claus-Steffen Sturzebecher, Jacquline Shukaiak-Quant, Henry F. McFarland
  • Inhibiting furin with polybasic peptides
    Patent number: 7569547
    Abstract: Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can improve inhibition of furin. High inhibition was seen in a series of non-amidated and non-acetylated polyarginines. The most potent inhibitor identified to date, nona-L-arginine, had a Ki against furin of 40 nM. Non-acetylated, poly-D-arginine-derived molecules are preferred furin inhibitors for therapeutic uses, such as inhibiting certain bacterial infections, viral infections, and cancers. Due to their relatively small size, these peptides should be non-immunogenic. These peptides are efficiently transported across cell membranes.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: August 4, 2009
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Torrey Pines Institute for Molecular Studies
    Inventors: Iris Lindberg, Angus Cameron, Richard A. Houghten, Jon Richard Appel
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20090043099
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 12, 2009
    Applicant: The Burnham Institute
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh
  • Melanin-Concentrating Hormone Receptor Antagonists and Methods of Use
    Publication number: 20080255218
    Abstract: This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).
    Type: Application
    Filed: March 23, 2005
    Publication date: October 16, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard A. Houghten, Colette Dooley, Adel Nefzi, Zhiwei Wang, Oliver Civelli, Hiroshi Nagasaki
  • Volatilizable solid phase supports for compound synthesis
    Patent number: 7396925
    Abstract: A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: July 8, 2008
    Assignee: Mixture Sciences, Inc.
    Inventors: Jeanick H. Pascal, Michael J. Moran, Richard A. Houghten
  • Methods and compositions for derepression of IAP-inhibited caspase
    Patent number: 7217688
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: May 15, 2007
    Assignees: The Burnham Institute, Torrey Pines Institute for Molecular Studies
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh
  • Pharmaceutical formulations and ligands for use therein; mimetics for UEA-1
    Patent number: 7166296
    Abstract: UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: January 23, 2007
    Assignee: Sarlan, Ltd.
    Inventors: Richard Houghten, Clemencia Pinilla, Imelda Lambkin, Daniel O'Mahony, Christa Hamashin, Amy Schink, Lisa Osthues-Spindler
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20070003535
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: March 17, 2005
    Publication date: January 4, 2007
    Inventors: John Reed, Richard Houghten, Adel Nefzi, John Ostresh, Clemencia Pinilla, Kate Welsh
  • Pharmaceutical Formulations and Ligands for Use Therein; Mimetics for UEA-1
    Publication number: 20060276628
    Abstract: UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes.
    Type: Application
    Filed: June 20, 2006
    Publication date: December 7, 2006
    Inventors: Richard Houghten, Clemencia Pinilla, Imelda Lambkin, Daniel O'Mahony, Christa Hamashin, Amy Schink, Lisa Osthues-Spindler