Patents by Inventor Richard I. Hogrefe

Richard I. Hogrefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triphosphate oligonucleotide modification reagents and uses thereof
    Publication number: 20040214199
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Application
    Filed: November 24, 2003
    Publication date: October 28, 2004
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Triphosphate oligonucleotide modification reagents and uses thereof
    Patent number: 6686461
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: February 3, 2004
    Assignee: Solulink Bioscience, Inc.
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Pre-activated carbonyl linkers for the modification of oligonucleotides
    Patent number: 6320041
    Abstract: The present invention provides a variety of compositions that comprise an activated carboxylic ester moiety on one end of an alkyl tether and a nucleic acid binding moiety on the other end for use as crosslinking reagents in conjugation reactions of nucleotides with solid support matrixes, organic molecules, reporter groups or other biomolecules.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: November 20, 2001
    Assignee: Trilink Biotechnologies, Inc.
    Inventors: Richard I. Hogrefe, Morteza M. Vaghefi
  • Synthetic oligomers having chirally pure phoshonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages
    Patent number: 5792615
    Abstract: Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: August 11, 1998
    Assignee: Genta, Incorporated
    Inventors: Lyle J. Arnold, Jr., Richard I. Hogrefe, Mark A. Reynolds, Timothy A. Riley, David A. Schwartz