Patents by Inventor Richard I. Morimoto

Richard I. Morimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of amyotrophic lateral sclerosis
    Patent number: 10167263
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: January 1, 2019
    Assignees: NORTHWESTERN UNIVERSITY, CAMBRIA PHARMACEUTICALS, INC.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Tian Chen, Richard B. Silverman
  • Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
    Patent number: 9593069
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: March 14, 2017
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Pyrimidine-2,4,6-triones for use in the treatment of amyotrophic lateral sclerosis
    Patent number: 9499494
    Abstract: The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: November 22, 2016
    Assignee: Northwestern University
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Guoyao Xia, Richard B. Silverman
  • Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
    Patent number: 9162968
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: October 20, 2015
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20150203456
    Abstract: The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
    Type: Application
    Filed: October 4, 2013
    Publication date: July 23, 2015
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Richard B. Silverman, Guoyao Xia
  • Cyclohexane-1,3-Diones for Use in the Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20140371313
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Application
    Filed: May 12, 2014
    Publication date: December 18, 2014
    Inventors: Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
    Patent number: 8722939
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: May 13, 2014
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • METHOD OF REDUCING PROTEINS MISFOLDING AND/OR AGGREGATION
    Publication number: 20130310439
    Abstract: The present invention is directed to methods of reducing protein misfolding and/or aggregation in a subject and to method of treating a condition mediated by a dysfunction in protein homeostasis comprising modulating cholinergic signaling activity.
    Type: Application
    Filed: November 5, 2012
    Publication date: November 21, 2013
    Inventors: Richard I. Morimoto, Maria Catarina Telo Baptista Lima Da Silva
  • Method of modulating HSF-1
    Patent number: 8551726
    Abstract: The present invention is directed to methods of modulating HSF1 activity comprising modifying the acetylation of the DNA binding domain of the HSF1.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: October 8, 2013
    Assignee: Northwestern University
    Inventors: Richard I. Morimoto, Sandy Westerheide, Julius Anckar, Lea Sistonen, Barbara Calamini
  • Cyclohexane-1,3-Diones for Use in the Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20120264765
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Application
    Filed: October 29, 2010
    Publication date: October 18, 2012
    Applicants: Cambria Pharmaceuticals, Inc., Northwestern University
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanties, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20120046309
    Abstract: The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
    Type: Application
    Filed: May 5, 2010
    Publication date: February 23, 2012
    Applicants: NORTHWESTERN UNIVERSITY, CAMBRIA PHARMACEUTICALS, INC.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Richard B. Silverman, Guoyao Xia
  • METHOD OF MODULATING HSF-1
    Publication number: 20110311508
    Abstract: The present invention is directed to methods of modulating HSF1 activity comprising modifying the acetylation of the DNA binding domain of the HSF1.
    Type: Application
    Filed: June 7, 2011
    Publication date: December 22, 2011
    Inventors: Richard I. Morimoto, Sandy Westerheide, Julius Anckar, Lea Sistonen, Barbara Calamini
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20110237907
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Application
    Filed: November 20, 2009
    Publication date: September 29, 2011
    Applicants: CAMBRIA PHARMACEUTICALS, INC., NORTHWESTERN UNIVERSITY
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Tian Chen, Richard B. Silverman
  • METHOD OF REGULATING THE HEAT SHOCK RESPONSE
    Publication number: 20110123512
    Abstract: The present invention is directed to method of modulating a heat shock response in a first cell of a multicellular organism comprising stimulating or inhibiting an HSR signaling activity of a second cell, wherein the second cell is a neuronal cell that regulates heat shock response activation in the first cell and that does not directly innervate the first cell.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 26, 2011
    Inventors: Veena Prahlad, Richard I. Morimoto
  • REDUCING POLYGLUTAMINE-BASED AGGREGATION
    Publication number: 20100158923
    Abstract: The disclosure features, inter alia, methods for treating or preventing neurodegenerative disorders and disorders that caused at least in part by polyglutamine aggregation. The method can include reducing activity of the IGF-1/GH axis in a subject. One exemplary neurodegenerative disorder that is also caused at least in part by polyglutamine aggregation is Huntington's disease.
    Type: Application
    Filed: January 19, 2010
    Publication date: June 24, 2010
    Inventors: Richard I. Morimoto, James F. Morley