Patents by Inventor Richard J. Bridges

Richard J. Bridges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aspartylamide inhibitors of excitatory amino acid transporters
    Patent number: 9499472
    Abstract: The compounds of the invention are inhibitors of excitatory amino acid transporters (EAAT) that penetrate the blood-brain barrier to access the central nervous system. The compounds of the invention follow the structural formula: or a salt, ester or prodrug thereof, wherein X is a halogen, such as fluorine, or a radionuclide, such as fluorine-18. The compounds and methods described herein can be used for the treatment of, e.g., neurodegenerative disorders (e.g., amyotrophic lateral sclerosis), ischemia, spinal cord injury, and traumatic brain injury in a patient (e.g., a human). The invention further provides compounds and methods for the synthesis and use of radiographic tracers to diagnose and follow the progression of such disorders.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: November 22, 2016
    Assignee: THE UNIVERSITY OF MONTANA
    Inventors: John M. Gerdes, Richard J. Bridges, Syed K. Ahmed, Sarjubhai Patel
  • Novel Inhibitors of System Xc-
    Publication number: 20150368213
    Abstract: The present invention is directed to novel inhibitors of system Xc?, also known as the cystine/glutamate antiporter. The present invention is further directed to methods of treating and detecting cancer that overexpresses system Xc? which includes but is not limited to gliomas (including glioblastoma), triple negative breast cancer, and bladder cancer. The present invention is further directed to methods of treating seizures including epileptic seizures.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 24, 2015
    Inventors: Nicholas R. Natale, Richard J. Bridges, Sarjubhai A. Patel, Nathan S. Duncan, Matthew J. Weaver, Mariusz P. Gajewski
  • Novel Aspartylamide Inhibitors of Excitatory Amino Acid Transporters
    Publication number: 20150023878
    Abstract: The compounds of the invention are inhibitors of excitatory amino acid transporters (EAAT) that penetrate the blood-brain barrier to access the central nervous system. The compounds of the invention follow the structural formula: or a salt, ester or prodrug thereof, wherein X is a halogen, such as fluorine, or a radionuclide, such as fluorine-18. The compounds and methods described herein can be used for the treatment of, e.g., neurodegenerative disorders (e.g., amyotrophic lateral sclerosis), ischemia, spinal cord injury, and traumatic brain injury in a patient (e.g., a human). The invention further provides compounds and methods for the synthesis and use of radiographic tracers to diagnose and follow the progression of such disorders.
    Type: Application
    Filed: March 5, 2013
    Publication date: January 22, 2015
    Inventors: John M. Gerdes, Richard J. Bridges, Syed K. Ahmed, Sarjubhai Patel
  • Method of inhibiting the transport of L-glutamate to treat CNS disorders
    Patent number: 5942537
    Abstract: A method of inhibiting the transport of a neurotransmitter away from the synapse comprising contacting a neurotransmitter transporter with a compound having the structure ##STR1## wherein ##STR2## or CONHR.sup.3 in any combination and and wherein R.sup.2 =OR.sup.3, NR.sup.3.sub.2, alkyl, or substituted alkyl and R.sup.3 =alkyl or substituted alkyl.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: August 24, 1999
    Assignee: The Regents of the University of California
    Inventors: A. Richard Chamberlin, Richard J. Bridges, Carl W. Cotman, Mark S. Stanley