Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: An apparatus and method for adding a velocity transducer to an electric motor, such as an elevator drive motor, includes mounting a shaft extension on an end surface of a motor shaft by drilling and tapping a bore at the shaft center as parallel as possible. A fastener with a bevel washer between a pair of flat washers attaches the extension to the motor shaft. With the fastener assembly snug, the extension is trued radially with a dial indicator. The bevel washer functions as a spring lock and distributes any off center clamping force produced from non-concentric hole drilling. A shoulder on the extension abuts the motor shaft end surface to maintain parallelism of the longitudinal axes of the shaft extension and the motor shaft. The shaft extension can be formed of an electrically nonconductive material to isolate the transducer from the drive equipment.

Abstract: An apparatus for use during modernization of a group of elevators to maintain optimum service to a building includes an Interim Traffic Manager (ITM) system which evenly distributes hall call routing between old and new elevator controls. During the time that an elevator to be re-equipped is out of service, the original not yet re-equipped elevators, as well as the already re-equipped elevators, respond as a single bank, one elevator car per call. The ITM system is connected between the hall call registering devices and each of old and new elevator controls. When a floor push button is pressed, the ITM system uses a routing algorithm to decide whether to send the call to the old or to the new elevator control based upon traffic loading. The ITM system is an inexpensive, reusable unit which resides on the job site temporarily and, therefore, adds no additional costs to the modernization of an elevator group.

Abstract: 1. In a mine of the character disclosed adapted to be planted on the bed of body of water from a surface vessel, the combination of a mine casing, a drag plate for the mine adapted to retard the downward movement thereof as the mine descends through the water, means including a line for detachably securing the drag plate to the casing in such a manner as to cause the casing to be righted during the descent of the mine through the water, and means effective when the mine reaches a predetermined depth of submergence for disconnecting the drag plate from the casing.

Abstract: Document images recorded upon microfilm using a first film transport are moved to a position to have an image thereof recorded upon a film carried by a second film transport thereby permitting the recording to be applied to the second film in accordance with the positioning of that film rather than in sequence.