Patents by Inventor Richard J. Caimi

Richard J. Caimi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE
    Publication number: 20230058309
    Abstract: One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
    Type: Application
    Filed: March 15, 2022
    Publication date: February 23, 2023
    Inventors: W. Scott Willett, Richard J. Caimi
  • SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE
    Publication number: 20210179679
    Abstract: One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
    Type: Application
    Filed: July 28, 2020
    Publication date: June 17, 2021
    Inventors: W. Scott Willett, Richard J. Caimi
  • SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE
    Publication number: 20200369735
    Abstract: One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
    Type: Application
    Filed: December 31, 2019
    Publication date: November 26, 2020
    Inventors: W. Scott Willett, Richard J. Caimi
  • SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE
    Publication number: 20180044387
    Abstract: One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
    Type: Application
    Filed: April 20, 2017
    Publication date: February 15, 2018
    Inventors: W. Scott Willett, Richard J. Caimi
  • Serum amyloid P derivatives and their preparation and use
    Patent number: 9296800
    Abstract: One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: March 29, 2016
    Assignee: Promedior, Inc.
    Inventors: W. Scott Willett, Richard J. Caimi
  • PULMONARY AND NASAL DELIVERY OF SERUM AMYLOID P
    Publication number: 20130064866
    Abstract: The disclosure relates to methods for delivery of serum amyloid P to the respiratory system. Pharmaceutical compositions comprising SAP suitable for respiratory delivery are also provided.
    Type: Application
    Filed: September 7, 2012
    Publication date: March 14, 2013
    Applicant: Promedior, Inc.
    Inventors: W. Scott Willett, Richard J. Caimi, Lynne Anne Murray
  • SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE
    Publication number: 20100317596
    Abstract: One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
    Type: Application
    Filed: June 4, 2010
    Publication date: December 16, 2010
    Inventors: W. Scott Willett, Richard J. Caimi
  • PULMONARY AND NASAL DELIVERY OF SERUM AMYLOID P
    Publication number: 20100266643
    Abstract: The disclosure relates to methods for delivery of serum amyloid P to the respiratory system. Pharmaceutical compositions comprising SAP suitable for respiratory delivery are also provided.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 21, 2010
    Inventors: W. Scott Willett, Richard J. Caimi, Lynne Anne Murray