Patents by Inventor Richard Jiao

Richard Jiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYDROCRACKING OPERATION WITH REDUCED ACCUMULATION OF HEAVY POLYNUCLEAR AROMATICS
    Publication number: 20240101913
    Abstract: Provided is a hydrocracking process with a recycle loop for converting a petroleum feed to lower boiling products, which process comprises reacting a stream over a non-zeolite noble metal catalyst at a temperature of about 650° F. (343° C.) or less in a reactor positioned in the recycle loop of the hydrocracking reactor.
    Type: Application
    Filed: December 29, 2021
    Publication date: March 28, 2024
    Applicant: CHEVRON U.S.A. INC.
    Inventors: Ling JIAO, Bi-Zheng ZHAN, Don BUSHEE, Theodorus Ludovicus Michael MAESEN, Hye-Kyung TIMKEN, Richard DUTTA, Jay PAREKH
  • THERMAL INTERFACE MATERIALS WITH WEAR-RESISTING LAYERS AND/OR SUITABLE FOR USE BETWEEN SLIDING COMPONENTS
    Publication number: 20190080981
    Abstract: Exemplary embodiments are disclosed of thermal interface materials with wear-resisting layers and/or suitable for use between sliding components. Also disclosed are devices including thermal interface materials and methods of using thermal interface materials.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Inventors: Daniel ZHAO, Richard JIAO
  • Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
    Patent number: 7786305
    Abstract: The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2. The present invention is also directed to intermediates useful in the preparation of formula I compounds.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: August 31, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Richard Jiao, Gregori Morriello, Lihu Yang, Changyou Zhou, Shankaran Kothandaraman, Christopher Moyes
  • Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
    Patent number: 7557124
    Abstract: Compounds of Formula I: (wherein n, R1, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: July 7, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Lihu Yang, Sander G. Mills, Richard Jiao
  • Amino cyclobutylamide modulators of chemokine receptor activity
    Patent number: 7553841
    Abstract: The present invention is directed to compounds of the formulas I and II: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R25, R26, Y, Z, l, m, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: June 30, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Richard Jiao, Lihu Yang
  • Tetrahydropyranyl Cyclopentyl Tetrahydropyridopyridine Modulators of Chemokine Receptor Activity
    Publication number: 20080021061
    Abstract: Compounds of Formula I: (wherein n, R1, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
    Type: Application
    Filed: April 22, 2005
    Publication date: January 24, 2008
    Inventors: Lihu Yang, Sander Mills, Richard Jiao
  • Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
    Patent number: 7230008
    Abstract: The present invention is directed to methods for treating, preventing, ameliorating, controlling or reducing the risk of an inflammatory or immunoregulatory disorder or disease, which method comprises the administration to a patient of an effective amount of the compound of formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: June 12, 2007
    Assignee: Merck & Co, Inc.
    Inventors: Richard Jiao, Gabor Butora, Stephen D. Goble, Deodialsingh Guiadeen, Sander G. Mills, Gregori Morriello, Alexander Pasternak, Cheng Tang, Lihu Yang, Changyou Zhou, Shankaran Kothandaraman, Christopher Moyes
  • Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
    Patent number: 7166614
    Abstract: The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: January 23, 2007
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Limited
    Inventors: Richard Jiao, Stephen D. Goble, Sander G. Mills, Gregori Morriello, Alexander Pasternak, Lihu Yang, Changyou Zhou, Gabor Butora, Shankaran Kothandaraman, Deodialsingh Guiadeen, Christopher Moyes
  • Amino cyclobutylamide modulators of chemokine receptor activity
    Publication number: 20060211722
    Abstract: The present invention is directed to compounds of the formulas I and II: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R25, R26, Y, Z, l, m, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Application
    Filed: March 15, 2004
    Publication date: September 21, 2006
    Inventors: Richard Jiao, Lihu Yang
  • Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
    Publication number: 20060089379
    Abstract: The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Application
    Filed: April 25, 2003
    Publication date: April 27, 2006
    Inventors: Richard Jiao, Stephen Goble, Sander Mills, Gregori Morriello, Alexander Pasternak, Lihu Yang, Changyou Zhou, Gabor Butora, Shankaran Kothandaraman, Deodialsingh Guiadeen, Christopher Moyes
  • Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
    Publication number: 20060030582
    Abstract: The present invention is directed to methods for treating, preventing, ameliorating, controlling or reducing the risk of a disorder or disease, which method comprises the administration to a patient of an effective amount of the compound of formula I: I (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Application
    Filed: April 8, 2005
    Publication date: February 9, 2006
    Inventors: Julie DeMartino, Taro Akiyama, Mary Struthers, Lihu Yang, Joel Berger, Gregori Morriello, Alexander Pastemak, Changyou Zhou, Sander Mills, Gabor Butora, Shankaran Kothandaraman, Deodialsingh Guiadeen, Cheng Tang, Richard Jiao, Stephen Goble, Christopher Moyes
  • Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
    Publication number: 20050107422
    Abstract: The present invention is directed to methods for treating, preventing, ameliorating, controlling or reducing the risk of an inflammatory or immunoregulatory disorder or disease, which method comprises the administration to a patient of an effective amount of the compound of formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Application
    Filed: August 20, 2004
    Publication date: May 19, 2005
    Inventors: Richard Jiao, Gabor Butora, Stephen Goble, Deodialsingh Guiadeen, Sander Mills, Gregori Morriello, Alexander Pasternak, Cheng Tang, Lihu Yang, Changyou Zhou, Shankaran Kothandaraman, Christopher Moyes
  • Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
    Publication number: 20050101628
    Abstract: The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2. The present invention is also directed to intermediates useful in the preparation of formula I compounds.
    Type: Application
    Filed: May 28, 2004
    Publication date: May 12, 2005
    Inventors: Richard Jiao, Gregori Morriello, Lihu Yang, Christopher Moyes, Changyou Zhou, Shankaran Kothandaraman
  • Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
    Patent number: 6812234
    Abstract: The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: November 2, 2004
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Ltd.
    Inventors: Richard Jiao, Gregori Morriello, Lihu Yang, Stephen D. Goble, Sander G. Mills, Alexander Pasternak, Changyou Zhou, Gabor Butora, Shankaran Kothandaraman, Deodialsingh Guiadeen, Christopher Moyes, Cheng Tang
  • TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
    Publication number: 20040167156
    Abstract: The present invention is directed to compounds of the formula I: 1
    Type: Application
    Filed: April 29, 2003
    Publication date: August 26, 2004
    Inventors: Richard Jiao, Gregori Morriello, Lihu Yang, Stephen D. Goble, Sander G. Mills, Alexander Pasternak, Changyou Zhou, Gabor Butora, Shankaran Kothandaraman, Deodialsingh Guiadeen, Christopher Moyes, Cheng Tang