Patents by Inventor Richard Koehn

Richard Koehn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitory oligonucleotides targeted to BCL-2
    Publication number: 20080096835
    Abstract: Inhibitory oligonucleotides are disclosed which are targeted to three specific target regions and subsequences of the target regions found on nucleic acids encoding Bcl-2. These inhibitory oligonucleotides are generally of from about 8 to about 50 nucleotides in length. Specific preferred oligonucleotides are disclosed. The oligonucleotides of the invention may be incorporated into compositions such as pharmaceutical compositions, and may be used in methods for inhibiting the expression of Bcl-2 in a cell or tissue, methods for treating conditions susceptible to modulation of Bcl-2 expression in an organism, and methods for detecting nucleic acid encoding BCL-2.
    Type: Application
    Filed: July 12, 2007
    Publication date: April 24, 2008
    Inventors: Zhidong Chen, Duane Ruffner, Ramesh Prakash, Richard Koehn
  • Inhibitory oligonucleotides targeted to Bcl-2
    Patent number: 7256284
    Abstract: Inhibitory oligonucleotides are disclosed which are targeted to three specific target regions and subsequences of the target regions found on nucleic acids encoding Bcl-2. These inhibitory oligonucleotides are generally of from about 8 to about 50 nucleotides in length. Specific preferred oligonucleotides are disclosed. The oligonucleotides of the invention may be incorporated into compositions such as pharmaceutical compositions, and may be used in methods for inhibiting the expression of Bcl-2 in a cell or tissue, methods for treating conditions susceptible to modulation of Bcl-2 expression in an organism, and methods for detecting nucleic acid encoding BCL-2.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: August 14, 2007
    Assignee: Genta Incorporated
    Inventors: Zhidong Chen, Duane E. Ruffner, Ramesh Prakash, Richard Koehn
  • Inhibitory oligonucleotides targeted to Bcl-2
    Publication number: 20040152654
    Abstract: Inhibitory oligonucleotides are disclosed which are targeted to three specific target regions and subsequences of the target regions found on nucleic acids encoding Bcl-2. These inhibitory oligonucleotides are generally of from about 8 to about 50 nucleotides in length. Specific preferred oligonucleotides are disclosed. The oligonucleotides of the invention may be incorporated into compositions such as pharmaceutical compositions, and may be used in methods for inhibiting the expression of Bcl-2 in a cell or tissue, methods for treating conditions susceptible to modulation of Bcl-2 expression in an organism, and methods for detecting nucleic acid encoding BCL-2.
    Type: Application
    Filed: November 14, 2003
    Publication date: August 5, 2004
    Inventors: Zhidong Chen, Duane E. Ruffner, Ramesh Prakash, Richard Koehn