Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract: Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Abstract: Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.

Abstract: In one embodiment, a computer accessible medium stores a plurality of instructions including instructions which, when executed: track dependencies among a plurality of assets; and responsive to an identification of an asset for potential recovery (the “selected asset”), identify an asset dependency set corresponding to the selected asset. The asset dependency set comprises at least a subset of the plurality of assets, wherein each asset in the subset has a dependency with the selected asset. In some embodiments, one or more of the following may be provided: tracking asset dependencies and presenting the asset dependency set to the user; pruning the asset dependency set to a recovery set identifying the asset dependency set; generating the recovery order (optionally optimized); initiating the recovery according to the recovery order; performing recovery steps; generating the recovery plan and/or executing recovery plans.

Abstract: A data processing network includes data sourcing entities, data logging entities that log data provided by the data sourcing entities, and a data transport network that supports data transport between the data sourcing entities and the data logging entities. The data logging entities and the data sourcing entities are interfaced to the data transport network in a manner that renders the data transport network transparent to the data logging entities and the data sourcing entities.

Abstract: In one embodiment, a computer accessible medium stores a plurality of instructions including instructions which, when executed: track dependencies among a plurality of assets; and responsive to an identification of an asset for potential recovery (the “selected asset”), identify an asset dependency set corresponding to the selected asset. The asset dependency set comprises at least a subset of the plurality of assets, wherein each asset in the subset has a dependency with the selected asset. In some embodiments, one or more of the following may be provided: tracking asset dependencies and presenting the asset dependency set to the user; pruning the asset dependency set to a recovery set identifying the asset dependency set; generating the recovery order (optionally optimized); initiating the recovery according to the recovery order; performing recovery steps; generating the recovery plan and/or executing recovery plans.

Abstract: A pipeline assembling apparatus used in assembling together large diameter PVC pipes into a pipeline includes a gripper assembly having an upright member for placement adjacent a side of an end of a second pipe to be inserted into an adjacent end of a first pipe and a pair of upper and lower horizontal members extending in cantilevered fashion outwardly from the upright member and generally parallel to one another for placement respectively above and below the end of the second pipe, an actuator assembly spaced from the gripper assembly and having a lower yoke of an inverted U-shape formed by a top horizontal member and a pair of vertical side members for placement over the end of the first pipe and a handle fixedly attached to the top horizontal member of the lower yoke, and a link member extending between and pivotally connected at one end to the upper horizontal member of the gripper assembly and at an opposite end to the handle of the actuator assembly such that by manually pulling on an upper extension o

Abstract: This invention provides a means of controlling the composition of electrodepositable photoresists emulsion. The system removes contaminants from the bath which may adversely effect the quality of the deposited coatings and allows for continuous monitoring of the conductivity of the system.