Patents by Inventor Richard Lu
Richard Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11983628Abstract: Systems and methods dynamically adjust an available range for editing an attribute in an image. An image editing system computes a metric for an attribute in an input image as a function of a latent space representation of the input image and a filtering vector for editing the input image. The image editing system compares the metric to a threshold. If the metric exceeds the threshold, then the image editing system selects a first range for editing the attribute in the input image. If the metric does not exceed the threshold, a second range is selected. The image editing system causes display of a user interface for editing the input image comprising an interface element for editing the attribute within the selected range.Type: GrantFiled: September 7, 2021Date of Patent: May 14, 2024Assignee: Adobe Inc.Inventors: Wei-An Lin, Baldo Faieta, Cameron Smith, Elya Shechtman, Jingwan Lu, Jun-Yan Zhu, Niloy Mitra, Ratheesh Kalarot, Richard Zhang, Shabnam Ghadar, Zhixin Shu
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Patent number: 11981708Abstract: The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.Type: GrantFiled: July 31, 2020Date of Patent: May 14, 2024Assignee: Children's Medical Center CorporationInventors: Richard Malley, Yingjie Lu, Fan Zhang
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Patent number: 11976097Abstract: The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.Type: GrantFiled: October 13, 2022Date of Patent: May 7, 2024Assignee: Children's Medical Center CorporationInventors: Richard Malley, Yingjie Lu, Fan Zhang
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Publication number: 20240109954Abstract: Described herein are Fe-enhanced antibodies and methods of use thereof. Also described are Fe-enhanced antibodies to treat Ebola virus infection.Type: ApplicationFiled: February 1, 2022Publication date: April 4, 2024Inventors: Galit Alter, Richard Lu
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Patent number: 11945900Abstract: The present disclosure provides an orthodontic article including the reaction product of the polymerizable composition. Further, the present disclosure provides polymerizable compositions and methods of making an orthodontic article. The method includes obtaining a polymerizable composition and selectively curing the polymerizable composition to form an orthodontic article. Further, methods are provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an orthodontic article; and generating, with the manufacturing device by an additive manufacturing process, the orthodontic article based on the digital object. A system is also provided, including a display that displays a 3D model of an orthodontic article; and one or more processors that, in response to the 3D model selected by a user, cause a 3D printer to create a physical object of an orthodontic article.Type: GrantFiled: June 27, 2019Date of Patent: April 2, 2024Assignee: 3M Innovative Properties CompanyInventors: Thomas P. Klun, Zeba Parkar, John M. Riedesel, Richard J. Pokorny, Chad M. Amb, Benjamin R. Coonce, Robert S. Clough, Tianyu Wu, Saswata Chakraborty, Yongshang Lu, Benjamin C. MacMurray, Ahmed S. Abuelyaman, Karl J. L. Geisler, Jodi L. Connell, Ta-Hua Yu
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Publication number: 20230034817Abstract: The disclosure pertains to a recombinant adeno-associated virus (rAAV) comprising an Anc80L65 capsid for delivering a polynucleotide (e.g., a transgene) into the central nervous system (CNS). Further provided includes methods for treating CNS diseases using the rAAV and pharmaceutical compositions comprising the rAAV.Type: ApplicationFiled: April 11, 2022Publication date: February 2, 2023Applicant: AFFINIA THERAPEUTICS INC.Inventors: Laura K. RICHMAN, Roberto CALCEDO DEL HOYO, Douglas N. SANDERS, Lisa M. STANEK, Samantha SMITH, Richard LU, Christopher TIPPER, Robert Steven Johnson
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Publication number: 20220163438Abstract: Modular flow cytometry systems and methods for processing samples are described herein. The systems include automated or semi-automated modules that are replaceable and removable. A sample pathway module may be removed and placed in a microfluidic device cleaning module for cleaning, and then reinstalled or stored for later use. The systems further include optical modules, electronics modules, and mixing and collection modules. The optical module includes a photo-damaging assembly and detection laser assembly that may be on the same side relative to a plane or surface of a flow cytometry device and opposite of a detection assembly. The laser beam may have a beam waist that is wider in a direction perpendicular to a flow direction than in the flow direction. The mixing and collection module can automatically mix a sample being collected in a sample tube and switch to another sample tube when the other tube is full.Type: ApplicationFiled: November 12, 2021Publication date: May 26, 2022Inventors: Gary Klas, Daniel McAda, Zheng Xia, Matthew Ebersole, Brian Lena, David Appleyard, Richard Lu, Scott Buckley, Mark Abermoske
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Patent number: 7937429Abstract: An equalization scheme for a transmission line employs a Taylor series expansion which enables the provided equalization to be adjusted based on line length. Multiple circuit blocks compute respective terms of the Taylor series, which are then summed to provide a compensating frequency response. For example, for a conductor having a frequency response given by H(f)=e?kl(1+j)?{square root over (f)}, where k is a constant dependent on the physical parameters of the conductor, l is the length of the conductor and f is the frequency of the signal propagated via the conductor, the present scheme provides an inverse frequency response H?1 (f) given by H?1 (f)= 1 + kl ? f 1 ! + k 2 ? l 2 ? f 2 ! + k 3 ? l 3 ? f 2 3 ! + … . The kl terms serve as weighting factors which vary with the length of the conductor.Type: GrantFiled: August 28, 2007Date of Patent: May 3, 2011Assignee: Analog Devices, Inc.Inventor: Yu-Lun Richard Lu
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Patent number: 7786765Abstract: A low voltage shutdown circuit comprises an input node for receiving a voltage Vin to be monitored, first and second voltage-to-current (V to I) converters arranged to receive Vin at respective inputs and to convert Vin to currents I1 and I2 at respective outputs, and a current comparison circuit arranged to produce an output which is in a first state when I1<I2 and in a second state when I1>I2. The V to I converters have respective voltage-to-current transfer functions which intersect at a non-zero threshold voltage Vth, such that the current comparison circuit output toggles when Vin<Vth. This output can be used as needed to, for example, trigger the shut down of other circuitry.Type: GrantFiled: February 15, 2008Date of Patent: August 31, 2010Assignee: Analog Devices, Inc.Inventors: Nathan R. Carter, Yu-Lun Richard Lu
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Patent number: 7769448Abstract: An implantable, multi-chamber cardiac stimulation device and method automatically adjust inter-chamber stimulation delays whenever stimulation rate is changed according to a patient's metabolic need. Inter-chamber stimulation delays include inter-atrial delays, inter-ventricular delays, and atrio-ventricular delays. Inter-chamber stimulation delays are defined according to whether the event which triggers the start of the delay is an intrinsic sensed event or the delivery of a stimulation pulse. Adjustment to inter-chamber stimulation delays is made as a function of the stimulation rate changes. By providing automatically adjustable inter-chamber stimulation delays optimal synchronization of heart chamber contractions may be maintained at all stimulation rates.Type: GrantFiled: May 6, 2005Date of Patent: August 3, 2010Assignee: Pacesetter, Inc.Inventor: Richard Lu
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Publication number: 20080197888Abstract: A low voltage shutdown circuit comprises an input node for receiving a voltage Vin to be monitored, first and second voltage-to-current (V to I) converters arranged to receive Vin at respective inputs and to convert Vin to currents I1 and I2 at respective outputs, and a current comparison circuit arranged to produce an output which is in a first state when I1<I2 and in a second state when I1>I2. The V to I converters have respective voltage-to-current transfer functions which intersect at a non-zero threshold voltage Vth, such that the current comparison circuit output toggles when Vin<Vth. This output can be used as needed to, for example, trigger the shut down of other circuitry.Type: ApplicationFiled: February 15, 2008Publication date: August 21, 2008Inventors: Nathan R. Carter, Yu-Lun Richard Lu
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Publication number: 20080086521Abstract: An equalization scheme for a transmission line employs a Taylor series expansion which enables the provided equalization to be adjusted based on line length. Multiple circuit blocks compute respective terms of the Taylor series, which are then summed to provide a compensating frequency response. For example, for a conductor having a frequency response given by H(f)=e?kl(1+j)?{square root over (f)}, where k is a constant dependent on the physical parameters of the conductor, l is the length of the conductor and f is the frequency of the signal propagated via the conductor, the present scheme provides an inverse frequency response H?1(f) given by H?1(f)= 1 + kl ? f 1 ! + k 2 ? l 2 ? f 2 ! + k 3 ? l 3 ? f 2 3 ! + … . The kl terms serve as weighting factors which vary with the length of the conductor.Type: ApplicationFiled: August 28, 2007Publication date: April 10, 2008Inventor: Yu-Lun Richard Lu
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Publication number: 20070255154Abstract: Techniques are described that allow an implantable device to sense activity data from a patient and estimate the patient's amount of energy expended based on the sensed data. The implantable device may alternatively determine an amount of time the patient has been active based on the activity data. For example, the implantable device may be an implantable gastric stimulator. A system may provide feedback to the patient, a family member, or a doctor about the patient's activity or energy expenditure. The data may be provided in table or graphical format, and may show daily or weekly energy data or may show a trend of the daily or weekly energy data.Type: ApplicationFiled: April 28, 2006Publication date: November 1, 2007Inventors: Richard Lu, John Keimel, Gary Lubben
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Publication number: 20070255337Abstract: The invention is directed to techniques for delivering electrical stimulation to a gastrointestinal tract of a patient via an implantable stimulator and monitoring electrical activity of a patient's heart by sensing cardiac signals via electrodes coupled to the implantable stimulator. The implantable stimulator may analyze the cardiac signals and generate a cardiac therapy recommendation for the patient, or may communicate the cardiac signals via telemetry circuitry to an external device for analysis. The sensed cardiac signals may be electrocardiogram (ECG) signals.Type: ApplicationFiled: April 28, 2006Publication date: November 1, 2007Inventor: Richard Lu
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Patent number: 7220120Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. The invention is further directed to compositions and methods used in lens casting. In a first implementation the invention includes a mold having a ring having an interior periphery; a front mold formed of a plastic and having a lens-forming surface, an edge circumscribing the lens-forming surface that is sized to be complementarily received within a portion of the interior periphery of the ring, and a base having dimensions greater than the interior periphery; and a rear mold formed of a plastic and having a lens-forming surface.Type: GrantFiled: July 22, 2005Date of Patent: May 22, 2007Assignee: Qspex, LLCInventors: Kai Su, Richard Lu, David Wright, Debbie Makita
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Patent number: 7212857Abstract: An implantable cardiac device returns activations of corresponding right and left chambers of a heart to inter-chamber synchrony. A sensing circuit senses intracardiac signals representing right and left chamber ventricular electrical activity. A detector determines if a predetermined characteristic of the electrogram signals indicates dissociation of the corresponding right and left chambers. If dissociation is indicated, a pulse generator stimulates at least one of the corresponding chambers to restore inter-chamber synchrony.Type: GrantFiled: May 1, 2002Date of Patent: May 1, 2007Assignee: Pacesetter, Inc.Inventors: Lisa P. Weinberg, Richard Lu
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Patent number: 7114696Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. In one implementation the invention includes a the casting device comprising a plurality of front molds, each front mold formed of a plastic and having a lens-forming surface. The front molds are configured to form a plurality of lenses of different effective diameters. The casting device further includes a rear mold formed of a plastic and having a lens-forming surface; wherein the rear mold is configured to be paired with each of the plurality of front molds to form a plurality of lenses of different effective diameters.Type: GrantFiled: August 29, 2005Date of Patent: October 3, 2006Assignee: QSPEX, LLCInventors: Kai Su, Richard Lu
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Publication number: 20060103037Abstract: The present invention comprises a method and apparatus for casting a lens, and chemical compositions used to perform the same. In one implementation of the invention, a disposable mold is provided that comprises a substantially amorphous thermoplastic material forming an optically precise surface; wherein the mold further comprises a coating on the optically precise surface of the mold, the coating configured to be incorporated into an ophthalmic lens and removable from the mold.Type: ApplicationFiled: November 18, 2004Publication date: May 18, 2006Inventors: Kai Su, Richard Lu, David Wright, Debbie Makita
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Publication number: 20060103041Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. The invention is further directed to compositions and methods used in lens casting. In a first implementation the invention includes a mold having a ring having an interior periphery; a front mold formed of a plastic and having a lens-forming surface, an edge circumscribing the lens-forming surface that is sized to be complementarily received within a portion of the interior periphery of the ring, and a base having dimensions greater than the interior periphery; and a rear mold formed of a plastic and having a lens-forming surface.Type: ApplicationFiled: November 18, 2004Publication date: May 18, 2006Inventors: Kai Su, Richard Lu, David Wright, Debbie Makita
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Publication number: 20060103038Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. The invention is further directed to compositions and methods used in lens casting. In a first implementation the invention includes a mold having a ring having an interior periphery; a front mold formed of a plastic and having a lens-forming surface, an edge circumscribing the lens-forming surface that is sized to be complementarily received within a portion of the interior periphery of the ring, and a base having dimensions greater than the interior periphery; and a rear mold formed of a plastic and having a lens-forming surface.Type: ApplicationFiled: July 22, 2005Publication date: May 18, 2006Inventors: Kai Su, Richard Lu, David Wright, Debbie Makita