Abstract: Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.

Abstract: Examples disclosed herein relate to propagating changes made on a file system volume of a primary cluster of nodes to the same file system volume also being managed by a secondary cluster of nodes. An application is executed on both clusters, and data changes on the primary cluster are mirrored to the secondary cluster using an exo-clone file. The exo-clone file includes the differences between two or more snapshots of the volume on the primary cluster, along with identifiers of the change blocks and (optionally) state information thereof. Just these changes, identifiers, and state information are packaged in the exo-clone file and then exported to the secondary cluster, which in turn makes the changes to its version of the volume. Exporting just the changes to the data blocks and the corresponding block identifiers drastically reduces the information needed to be exchanged and processed to keep the two volumes consistent.

Abstract: A fault detector for detecting the occurrence of a rapid pressure rise within electrical equipment. The fault detector has a chamber having an interior, a diaphragm in sealing engagement with the chamber and an aperture providing fluid communication between the interior of the chamber and the external environment of the chamber.

Abstract: A fastener assembly to be used in the construction of semi-trailers consisting of a first fastener having a head and a shank, a mating second fastener, and a plurality of axially extending knurls formed on the shank. The knurls engage in a hole for receiving the first fastener to prevent rotation and removal of the first fastener. The first fastener may also be provided with an encapsulating cover with two sealing points on its underside to seal the fastener to a surface through which the fastener is inserted.

Abstract: A method for debugging a processor which is executing vertices of a software application is described. Each vertex is assigned to a programming thread of the processor. The processor has debug hardware for raising exceptions in certain break conditions. The method comprises inspecting a vertex identifier, comparing the vertex identifier and raising an instruction exception event for the programming thread if the vertex identifier assigned to the thread matches the vertex break identifier in the debug hardware. Exceptions are raised based on identified vertices, rather than just individual instructions or instruction addresses.

Abstract: A fastener assembly to be used in the construction of semi-trailers consisting of a first fastener having a head and a shank, a mating second fastener, and a plurality of axially extending knurls formed on the shank. The knurls engage in a hole for receiving the first fastener to prevent rotation and removal of the first fastener. The first fastener may also be provided with an encapsulating cover with two sealing points on its underside to seal the fastener to a surface through which the fastener is inserted.

Abstract: Two or more die are stacked together in a stacked integrated circuit device. Each of the processors on these die is able to communicate with other processors on its die by sending data over the switching fabric of its respective die. The mechanism for sending data between processors on the same die (i.e. intradie communication) is reused for sending data between processors on different die (i.e. interdie communication). The reuse of the mechanism is enabled by assigning each processor a vertical neighbour on its opposing die. Each processor has an interdie connection that connects it to the output exchange bus of its neighbour. A processor is able to borrow the output exchange bus of its neighbour by sending data along the output exchange bus of its neighbour.