Patents by Inventor Richard M. Carlton

Richard M. Carlton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140283441
    Abstract: A method of increasing yield of cultivated algae, which entails the step of cultivating one or more species of algae in the presence of one or more species of PPFM bacteria, for at least a portion of the algae cultivation.
    Type: Application
    Filed: June 11, 2014
    Publication date: September 25, 2014
    Inventors: Mark Holland, Patrick BiBello, Richard M. Carlton
  • Patent number: 8778660
    Abstract: A method of increasing yield of cultivated algae, which entails the step of cultivating one or more species of algae in the presence of one or more species of PPFM bacteria, for at least a portion of the algae cultivation.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: July 15, 2014
    Assignee: NewLeaf Symbiotics, Inc.
    Inventors: Mark Holland, Patrick Di Bello, Richard M. Carlton
  • Publication number: 20110269219
    Abstract: A method of increasing yield of cultivated algae, which entails the step of cultivating one or more species of algae in the presence of one or more species of PPFM bacteria, for at least a portion of the algae cultivation.
    Type: Application
    Filed: April 22, 2011
    Publication date: November 3, 2011
    Inventors: Mark Holland, Patrick Di Bello, Richard M. Carlton
  • Publication number: 20080318867
    Abstract: The present invention relates to virulent (lytic) Listeria monocytogenes phage from the Myoviridae family, preferably P100, alone or in combination with other virulent phages. P100 and the endolysin from P100 can be administered to food products, to the components that will be added to food products, and/or to the infrastructure of the food processing plants within which such food products are processed, or the containers or wraps in which such foods are stored and/or shipped, in order to reduce Listeria monocytogenes contamination. P100 can also be used in the present invention to identify Listeria monocytogenes bacteria present on (or within) foodstuffs, as well as those Listeria monocytogenes bacteria present in the equipment or the general environment of the food processing plants in which the foodstuffs are being processed and in animals infected with Listeria monocytogenes. The phage and the endolysin of the present invention can also be used to treat animals infected with Listeria monocytogenes.
    Type: Application
    Filed: August 28, 2008
    Publication date: December 25, 2008
    Applicant: EBI Food Safety B.V.
    Inventors: Martin LOESSNER, Richard M. Carlton
  • Patent number: 7438901
    Abstract: The present invention relates to virulent (lytic) Listeria monocytogenes phage from the Myoviridae family, preferably P100, alone or in combination with other virulent phages. P100 and the endolysin from P100 can be administered to food products, to the components that will be added to food products, and/or to the infrastructure of the food processing plants within which such food products are processed, or the containers or wraps in which such foods are stored and/or shipped, in order to reduce Listeria monocytogenes contamination. P100 can also be used in the present invention to identify Listeria monocytogenes bacteria present on (or within) foodstuffs, as well as those Listeria monocytogenes bacteria present in the equipment or the general environment of the food processing plants in which the foodstuffs are being processed and in animals infected with Listeria monocytogenes. The phage and the endolysin of the present invention can also be used to treat animals infected with Listeria monocytogenes.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: October 21, 2008
    Assignee: Exponential Biotherapies, Inc.
    Inventors: Martin Loessner, Richard M. Carlton
  • Patent number: 7332307
    Abstract: The present invention is directed to bacteriophage therapy, using methods which enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects. The HDS normally reduces the number of bacteriophage in an animal, which decreases the efficiency of the bacteriophage in killing the host bacteria present during an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes by physico-chemical alteration of the bacteriophage surface proteins, so that the altered bacteriophage remain active in the body for longer periods of time than the unmodified bacteriophage.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: February 19, 2008
    Assignees: The United States of America as represented by the Department of Health and Human Services, Exponential Biotherapies, Inc.
    Inventors: Richard M. Carlton, Carl R. Merril, Sankar L. Adhya
  • Publication number: 20040161431
    Abstract: The present invention is directed to bacteriophage therapy, using methods which enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects. The HDS normally reduces the number of bacteriophage in an animal, which decreases the efficiency of the bacteriophage in killing the host bacteria present during an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes by physico-chemical alteration of the bacteriophage surface proteins, so that the altered bacteriophage remain active in the body for longer periods of time than the unmodified bacteriophage.
    Type: Application
    Filed: September 11, 2003
    Publication date: August 19, 2004
    Inventors: Richard M. Carlton, Carl R. Merril, Sankar L. Adhya
  • Publication number: 20040161411
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Application
    Filed: September 11, 2003
    Publication date: August 19, 2004
    Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
  • Publication number: 20030026785
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Application
    Filed: June 19, 1997
    Publication date: February 6, 2003
    Inventors: CARL R. MERRIL, RICHARD M. CARLTON, SANKAR L. ADHYA
  • Publication number: 20010043917
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Application
    Filed: May 30, 2001
    Publication date: November 22, 2001
    Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
  • Publication number: 20010043924
    Abstract: The present invention is directed to bacteriophage therapy, using methods which enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects. The HDS normally reduces the number of bacteriophage in an animal, which decreases the efficiency of the bacteriophage in killing the host bacteria present during an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes by physico-chemical alteration of the bacteriophage surface proteins, so that the altered bacteriophage remain active in the body for longer periods of time than the unmodified bacteriophage.
    Type: Application
    Filed: May 29, 2001
    Publication date: November 22, 2001
    Applicant: Exponential Biotherapies, Inc.
    Inventors: Richard M. Carlton, Carl R. Merril, Sankar L. Adhya
  • Publication number: 20010026795
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Application
    Filed: May 21, 2001
    Publication date: October 4, 2001
    Applicant: Exponential Biotherapies, Inc.
    Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
  • Patent number: 5811093
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging of a bacteriophage, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: September 22, 1998
    Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
  • Patent number: 5766892
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 16, 1998
    Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
  • Patent number: 5688501
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: November 18, 1997
    Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
  • Patent number: 5660812
    Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 26, 1997
    Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya