Abstract: Binding members for sodium channel Nav1.7 and their use in medicine including for treatment of pain or epilepsy. Binding members comprise a fusion protein containing a Nav1.7-binding peptide, e.g., venom toxin peptide or knottin (“donor diversity scaffold domain”) inserted within an antibody variable domain (“recipient diversity scaffold domain”), and a partner domain (e.g., antibody variable domain), optionally wherein the partner domain enhances specificity of binding to Nav1.7 over other sodium channels.

Abstract: A system for distributing network traffic to multiple traffic management devices. A distributor receives each packet from a network and may act as a layer 2 switch, a router, or distribute the packet to one of a group of traffic management devices. The distributor may receive packets from servers that the traffic management devices are managing communications to. When distributing packets to traffic management devices, information such as source and destination addresses may be used to determine which traffic management device each packet should be sent to. The distributor causes packets that are part of a flow to be delivered to the same traffic management device.