Abstract: Cancer markers are developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genome wide analyses of genome copy number and gene expression in breast cancer revealed 66 genes in the human chromosomal regions, 8p11, 11q13, 17q12, and 20q13 that were amplified. Diagnosis and assessment of amplification levels of genes shown to be amplified are useful in prediction of patient outcome of a of patient's response and drug resistance in breast cancer. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically breast cancer. Inhibitors of these genes will be useful therapies for treatment of these non-responsive cancers.

Abstract: A computer readable storage medium includes executable instructions to calculate a default number of major tick marks as a function of a minimum distance between major tick marks and the length of a GUI control. A whole number of major tick marks that evenly divides a range of values to be mapped along the length of the GUI control is iteratively searched. A whole number of major tick marks is displayed along the length of the GUI control. The default number of major tick marks is the origin from which the search begins.

Abstract: The present invention relates to a receptor molecule which binds to TNF comprising all or a functional portion of the extracellular domain (ECD) of two or more TNF-Rs linked via one or more polypeptide linkers. The receptor can further comprise a signal peptide of a secreted protein, such as the signal peptide of the extracellular domain of the TNF-R or the signal peptide of a cytokine. The invention also relates to isolated DNA encoding a receptor molecule which binds to TNF, comprising two or more sequences encoding all or a functional portion of the ECD of TNF-Rs linked via one or more sequences encoding a polypeptide linker. The invention further relates to a method of making a construct which expresses all or a functional portion of the ECD of two or more TNF-Rs linked via one or more polypeptide linkers and cells which express the construct.

Abstract: A computer readable storage medium includes executable instructions to calculate a default number of major tick marks as a function of a minimum distance between major tick marks and the length of a GUI control. A whole number of major tick marks that evenly divides a range of values to be mapped along the length of the GUI control is iteratively searched. A whole number of major tick marks is displayed along the length of the GUI control. The default number of major tick marks is the origin from which the search begins.

Abstract: Cancer markers are developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genome wide analyses of genome copy number and gene expression in breast cancer revealed 66 genes in the human chromosomal regions, 8p11, 11q13, 17q12, and 20q13 that were amplified. Diagnosis and assessment of amplification levels of genes shown to be amplified are useful in prediction of patient outcome of a of patient's response and drug resistance in breast cancer. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically breast cancer. Inhibitors of these genes will be useful therapies for treatment of these non-responsive cancers.

Abstract: The present invention relates to a receptor molecule which binds to TNF comprising all or a functional portion of the extracellular domain (ECD) of two or more TNF-Rs linked via one or more polypeptide linkers. The receptor can further comprise a signal peptide of a secreted protein, such as the signal peptide of the extracellular domain of the TNF-R or the signal peptide of a cytokine. The invention also relates to isolated DNA encoding a receptor molecule which binds to TNF, comprising two or more sequences encoding all or a functional portion of the ECD of TNF-Rs linked via one or more sequences encoding a polypeptide linker. The invention further relates to a method of making a construct which expresses all or a functional portion of the ECD of two or more TNF-Rs linked via one or more polypeptide linkers and cells which express the construct.

Abstract: The present invention provides methods, systems, and computer program instructions for providing location-independent packet routing and secure access in a wireless networking environment (such as that encountered within a building), enabling client devices to travel seamlessly within the environment. Each client device uses a constant address. An address translation process that is transparent to the client and server is automatically performed as the device roams through the environment, enabling efficient client migration from one supporting access point to another. The secure access techniques provide user-centric authentication and allow policy-driven packet filtering, while taking advantage of encryption capabilities that are built in to the hardware at each endpoint.

Abstract: The present invention relates to a receptor molecule which binds to TNF comprising all or a functional portion of the extracellular domain (ECD) of two or more TNF-Rs linked via one or more polypeptide linkers. The receptor can further comprise a signal peptide of a secreted protein, such as the signal peptide of the extracellular domain of the TNF-R or the signal peptide of a cytokine. The invention also relates to isolated DNA encoding a receptor molecule which binds to TNF, comprising two or more sequences encoding all or a functional portion of the ECD of TNF-Rs linked via one or more sequences encoding a polypeptide linker. The invention further relates to a method of making a construct which expresses all or a functional portion of the ECD of two or more TNF-Rs linked via one or more polypeptide linkers and cells which express the construct.

Abstract: This invention is based upon the discovery that EPHA2, BAG4, and ARF1 are amplified and overexpressed in cancer. The present invention therefore provides methods, reagents, and kits for diagnosing and treating breast cancer.

Abstract: A general, event/handler kernel extension system is implemented. Network server extension architecture isolates and exploits the ability to derive responses on the same interrupt the original request was received on using non-paged memory. TCP network server extensions are implemented. A technique is defined for facilitating immediate completion of connection requests using pre-allocated connection endpoints and describes an approach to recycling these connection endpoints. A hybrid HTTP extension implemented partially in user space and partially in kernel space is defined that provides explicit or transparent implementation of the user space component and shared logging between user and kernel space. A technique is defined for prefetching responses to HTTP GET requests using earlier GET responses. Classifying of handler extensions according to latency in deriving a response to a network request is defined.