Patents by Inventor Richard O. Cliff

Richard O. Cliff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEATED CELL PRESERVATION BY LYOPHILIZATION
    Publication number: 20210368782
    Abstract: The invention provides freeze-dried nucleated cells, a method for preparing them, and methods of using them for in vitro assays and in vivo therapeutic treatments. The method for preparing the cells includes incubating cells in the presence of a cryoprotective sugar to load them with the sugar, then lyophilizing them without separating the cells from the cryoprotective sugar. In embodiments, the cells are also loaded with one or more bioactive agents.
    Type: Application
    Filed: August 13, 2021
    Publication date: December 2, 2021
    Applicant: CELLPHIRE INC.
    Inventors: Joshua Dee, Anna Yu, Glen Michael Fitzpatrick, Richard O. Cliff
  • NUCLEATED CELL PRESERVATION BY LYOPHILIZATION
    Publication number: 20190008143
    Abstract: The invention provides freeze-dried nucleated cells, a method for preparing them, and methods of using them for in vitro assays and in vivo therapeutic treatments. The method for preparing the cells includes incubating cells in the presence of a cryoprotective sugar to load them with the sugar, then lyophilizing them without separating the cells from the cryoprotective sugar. In embodiments, the cells are also loaded with one or more bioactive agents.
    Type: Application
    Filed: January 10, 2017
    Publication date: January 10, 2019
    Inventors: Joshua Dee, Anna Yu, Glen Michael Fitzpatrick, Richard O. Cliff
  • Methods for detecting A? oligomers
    Patent number: 10139419
    Abstract: Methods of detecting A? oligomers, such as may be present in a biological sample are described. The methods include detection using flow cytometry, detection using synthetic A? oligomers and/or in vitro methods detecting A? oligomers associated with cells.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: November 27, 2018
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Richard O. Cliff, Robert W. Flower, Evgenia G. Matveeva
  • METHODS FOR DETECTING Aß OLIGOMERS
    Publication number: 20160169913
    Abstract: Methods of detecting A? oligomers, such as may be present in a biological sample are described. The methods include detection using flow cytometry, detection using synthetic A? oligomers and/or in vitro methods detecting A? oligomers associated with cells.
    Type: Application
    Filed: September 4, 2015
    Publication date: June 16, 2016
    Applicant: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Richard O. Cliff, Robert W. Flower, Evgenia G. Matveeva
  • Method for producing sterile filterable liposome dispersion
    Patent number: 6033708
    Abstract: The present invention relates to a composition and method of producing noggregating, filterable dispersion of liposome encapsulated agent or therapeutic of interest, specifically hemoglobin. A key step in the method of the present invention is the addition of a passivating protein prior to hydration of the liposomes with the agent of interest. The resulting dispersion is composed of unilamellar vesicles having a diameter of less than or equal to 0.2 microns.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: March 7, 2000
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Victoria Kwasiborski, Richard O. Cliff, Alan S. Rudolph