Patents by Inventor Richard O Nicholas

Richard O Nicholas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 7422749
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 9, 2008
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Michael T. Black, Martin K. Burnham, Jason C. Fedon, John E. Hodgson, David J. Knowles, Michael A. Lonetto, Richard O. Nicholas, Leslie M. Palmer, Julie M. Pratt, Raymond W. Reichard, Martin Rosenberg, Christopher M. Traini, Judith Ward, Richard L. Warren
  • Purified polypeptides from
    Patent number: 7250285
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: July 31, 2007
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Robert King Stodola, Martin Karl Russel Burnham
  • Novel compounds
    Publication number: 20040014037
    Abstract: The invention provides RF-1 polypeptides and DNA (RNA) encoding RF-1 polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RF-1 polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: September 14, 2001
    Publication date: January 22, 2004
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Richard O. Nicholas, Robert King Stodola
  • Compounds
    Patent number: 6465621
    Abstract: The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 15, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward
  • Novel prokaryotic polynucleotides, polypeptides and their uses
    Publication number: 20020082234
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: August 27, 2001
    Publication date: June 27, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Michael Arthur Lonetto
  • Novel glucosaminidase
    Publication number: 20020076766
    Abstract: The invention provides glucosaminidase polypeptides and DNA (RNA) encoding glucosaminidase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glucosaminidase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: January 25, 2001
    Publication date: June 20, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Simon J. Foster
  • Novel histidinol dehydrogenase
    Publication number: 20020064848
    Abstract: The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 14, 2001
    Publication date: May 30, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • defl
    Publication number: 20020058796
    Abstract: The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 21, 2001
    Publication date: May 16, 2002
    Inventors: Michael A. Lonetto, David J. Holmes, Deborah D. Jaworski, Richard O. Nicholas, Min Wang, Robert K. Stodola, Anna L. Kosmatka, Richard L. Warren, David J.C. Knowles, Christopher M. Traini, John E. Hodgson
  • ama
    Publication number: 20020052472
    Abstract: The invention provides ama polypeptides and polynucleotides encoding ama polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ama polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: January 12, 2001
    Publication date: May 2, 2002
    Inventors: David T. Beattie, Robert L. Deresiewicz, Adrian M. Lowe, Michael A. Lonetto, John E. Hodgson, Richard O. Nicholas, Leslie Marie Palmer, Julie M. Pratt
  • Prokaryotic polynucleotides polypeptides and their uses
    Patent number: 6348582
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: February 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto
  • Polynucleotides encoding a novel glutamine transport ATP-binding protein
    Patent number: 6346392
    Abstract: The invention provides Glutamine Transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Glutamine Transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glutamine Transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: February 12, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Martin Karl Russel Burnham, Robert H Reid, Jr., Phillip N Zarfos
  • Novel glucosaminidase
    Publication number: 20010039038
    Abstract: The invention provides glucosaminidase polypeptides and DNA (RNA) encoding glucosaminidase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glucosaminidase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: January 25, 2001
    Publication date: November 8, 2001
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Simon J. Foster
  • SigB
    Patent number: 6310192
    Abstract: SigB polypeptides and DNA (RNA) encoding such SigB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such SigB for the treatment of infection, particularly bacterial infections. Antagonists against such SigB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of SigB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: October 30, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Andrew P Fosberry, Elizabeth J Lawlor, Richard O Nicholas
  • MurC from Streptococcus pneumoniae
    Patent number: 6310193
    Abstract: The invention provides MurC polypeptides and DNA (RNA) encoding MurC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: October 30, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Robert King Stodola, Nicola Gail Wallis
  • RsbV-1 from staphylococcus aureus
    Patent number: 6297358
    Abstract: RsbV-1 polypeptides and DNA (RNA) encoding such RsbV-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such RsbV-1 for the treatment of infection, particularly bacterial infections. Antagonists against such RsbV-1 and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of RsbV-1 nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: October 2, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Andrew P Fosberry, Elizabeth J Lawlor, Richard O Nicholas
  • Compounds
    Patent number: 6294661
    Abstract: The invention provides RF-1 polypeptides and DNA (RNA) encoding RF-1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RF-1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: September 25, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Richard O Nicholas, Robert King Stodola
  • Ferrichrome transport ATP-binding protein
    Patent number: 6264955
    Abstract: The invention provides Ferrichrome transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Ferrichrome transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Ferrichrome transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: July 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren, Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham
  • ERA
    Patent number: 6248556
    Abstract: The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, Martin Karl Russel Burnham, John Edward Hodgson, David Justin Charles Knowles, Richard O Nicholas, Julie M Pratt, Raymond Winfield Reichard, Martin Rosenberg, Judith M Ward
  • Histidinol dehydrogenase
    Patent number: 6248576
    Abstract: The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Riechard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Ribosome recycling factor (FRR) of Staphylococcus aureus
    Patent number: 6238887
    Abstract: This invention provides frr polypeptides and polynucleotides encoding frr polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing frr polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: May 29, 2001
    Assignees: Brigham & Women's Hospital, Virus Research Institute, SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: David T Beattie, Robert L Deresiewicz, Adrian M Lowe, Michael A Lonetto, John E Hodgson, Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt