Abstract: The present disclosure relates to an inhaler adapted to supply a formulation comprised in a container to a user, the inhaler being adapted to read information stored in data storage means of the container. The present disclosure also relates to a system comprising such an inhaler and the container comprising the formulation, the container further comprising the data storage means storing the information. The present disclosure also relates to a container comprising a formulation, the container further comprising data storage means storing information, the container being adapted for supplying the formulation to a user, wherein the container is adapted for usage in an inhaler of any of the preceding claims. The disclosure also relates to set comprising the inhaler and a computing device external of the inhaler, wherein the inhaler and the computing device are adapted to communicate with each other. The disclosure also relates to the use of the inhaler, container, set and/or system for inhalation therapy.

Abstract: The present invention relates to a method for measuring at least one inhalation flow feature in an inhaler, wherein a capsule containing a formulation is located in the inhaler, the method comprising the steps of sensing an impact feature relating to impacts of the capsule on the inhaler and correlating the impact feature to at least one inhalation flow feature. The present invention also relates to an inhaler adapted to aerosolize a formulation contained in a capsule, wherein the inhaler comprises a sensor for sensing an impact feature relating to impacts of the capsule on the inhaler and a processor for correlating the impact feature to at least one inhalation flow feature.

Abstract: Laser siping forms sipes in an article. The laser operates in a scan laser configuration for some sipe patterns and the laser operates in a fixed laser concept for other siping patterns. The article on which the sipes are formed is secured by a part holder. Movement of the part holder may be computer controlled. Movement of the laser may also be computer controlled. A movement of a reflective surface of the laser may be computer controlled. Together, the movement of the part holder, the laser, and the reflective surface is coordinated to achieve the scan laser configuration and the fixed laser configuration when forming sipes.

Abstract: Pharmaceutical aerosol formulations of dihydroergotamine, or pharmaceutically acceptable salts thereof, to administer dry powders and propellant suspensions via pulmonary aerosol or nasal spray inhalation. Such formulations may be used for the treatment of various disease states and conditions, including, but not limited to, migraine headaches. The dihydroergotamine particles are produced using a supercritical fluid process. The aerosol formulations disclosed have superior stability, purity and comprise particle of respirable size particularly suitable for pulmonary delivery.