Abstract: The present technology is directed to adjustable shunts for treating glaucoma. In particular, some embodiments provide shunts having a plurality of individually actuatable flow control elements that can control the flow of fluid through associated ports and/or flow lumens. For example, each individually actuatable flow control element can be actuated to modify a flow of a corresponding port and/or flow lumen. The individually actuatable flow control elements may be actuated along a given actuation axis. A flow control assembly may include a plurality of flow control elements arranged about a collection region. Accordingly, the shunts described herein can be manipulated into a variety of configurations that provide different drainage rates based on a degree to which the ports and/or flow lumens are blocked or unblocked, therefore providing a titratable glaucoma therapy for draining aqueous from the anterior chamber of the eye.

Abstract: The present invention relates to systems and methods for improving the accuracy of disease diagnosis and to associated diagnostic tests involving the correlation of measured analytes with binary outcomes (e.g., not-disease or disease), as well as higher-order outcomes (e.g., one of several phases of a disease). Methods of the present invention use biomarker sets, preferably those with orthogonal functionality, to obtain concentration and proximity score values for disease and non-disease states. The biomarker a set's proximity scores are graphed on an orthogonal grid, with one dimension for each biomarker. The proximity scores and orthogonal gridding is then used to calculate a disease state or non-disease state diagnosis for the patient.

Abstract: The present invention relates to systems and methods for improving the accuracy of disease diagnosis and to associated diagnostic tests involving the correlation of measured analytes with binary outcomes (e.g., not-disease or disease), as well as higher-order outcomes (e.g., one of several phases of a disease). Methods of the present invention use biomarker sets, preferably those with orthogonal functionality, to obtain concentration and proximity score values for disease and non-disease states. The biomarker set's proximity scores are graphed on an orthogonal grid, with one dimension for each biomarker. The proximity scores and orthogonal gridding is then used to calculate a disease state or non-disease state diagnosis for the patient.

Abstract: A modular microscope can quickly be modified for specific scanning applications. The microscope includes a microscope main body which has slots into which long pass filter modules, dichroic mirror modules, notch filter modules, and LED modules can be selectively placed, removed, and changed out. In some applications, the interchangeable components permit quickly changing between Photoluminescence (PL) and Raman spectroscopy (microscope) systems.

Abstract: The present invention relates to systems and methods for improving the accuracy of disease diagnosis and to associated diagnostic tests involving the correlation of measured analytes with binary outcomes (e.g., not-disease or disease), as well as higher-order outcomes (e.g., one of several phases of a disease). Methods of the present invention use biomarker sets, preferably those with orthogonal functionality, to obtain concentration and proximity score values for disease and non-disease states. The biomarker a set's proximity scores are graphed on an orthogonal grid, with one dimension for each biomarker. The proximity scores and orthogonal gridding is then used to calculate a disease state or non-disease state diagnosis for the patient.

Abstract: The present invention concerns a novel means by which liquids can be moved or mixed. Microwaves strike and heat materials that are highly susceptible to microwave heating. The susceptible materials are on, within, or near materials that melt or change shape in response to temperature increases. Upon microwave irradiation, these materials change shape (e.g., shrink or melt), causing the movement of liquids. The invention is important in many microfluidics applications, especially in biomedical analysis, where it is valuable to be able to move small volumes of liquids (e.g., on a microarray chip).

Abstract: The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many small scale chemical transformations including those used in protein chemistry and in combinatorial chemistry.

Abstract: An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectively, attached to a surface of the microcantilever.

Abstract: Compositions and methods for binding to assay substrata in a stable and protective manner, thereby enhancing assay performance, are provided. The compositions comprise lyotropic materials (for example, lyotropic liquid and/or liquid crystalline materials) and may contain macromolecular standards, markers or capture compounds. The compositions are capable of binding to assay substrata such as that of chips that are employed for MALDI and SELDI mass spectroscopy analyses and plates that are used for ELISA type assays.

Abstract: The present invention concerns a novel means by which liquids can be moved or mixed. Microwaves strike and heat materials that are highly susceptible to microwave heating. The susceptible materials are on, within, or near materials that melt or change shape in response to temperature increases. Upon microwave irradiation, these materials change shape (e.g., shrink or melt), causing the movement of liquids. The invention is important in many microfluidics applications, especially in biomedical analysis, where it is valuable to be able to move small volumes of liquids (e.g., on a microarray chip).

Abstract: An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectively, attached to a surface of the microcantilever.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Sunrise’, characterized by its upright and columnar plant habit; freely branching growth habit; large inflorescences with pale yellow-colored ray florets and orange-tipped receptacle spines; relatively early flowering habit; fragrant inflorescences; and good garden performance.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Sunset’, characterized by its upright and columnar plant habit; freely branching growth habit; large inflorescences with light red-colored ray florets and brownish orange-tipped receptacle spines; relatively early flowering habit; fragrant inflorescences; and good garden performance.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Paranoia’, characterized by its short, compact plant habit and buttery yellow reflexed ray flowers arranged around a coppery-brown cone of many disc florets.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Twilight’, characterized by its upright and columnar plant habit; freely branching growth habit; large inflorescences with red purple-colored ray florets and dark purple-tipped receptacle spines; relatively early flowering habit; fragrant inflorescences; and good garden performance.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Matthew Saul’, characterized by its upright and columnar plant habit; vigorous and freely branching growth habit; inflorescences with golden yellow-colored ray florets and orange-colored receptacle spines; and good garden performance.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Evan Saul’, characterized by its upright and columnar plant habit; vigorous and freely branching growth habit; inflorescences with orange-colored ray florets and dark purple-colored receptacle spines; and good garden performance.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Emily Saul’, characterized by its relatively compact, upright and columnar plant habit; freely branching habit; large single inflorescence with dark red purple-colored ray florets, relatively large inflorescence discs; and strong flowering stems that hold the inflorescences upright.

Abstract: A new and distinct cultivar of Echinacea plant named ‘Katie Saul’, characterized by its upright and columnar plant habit; vigorous growth habit; freely branching habit; large single inflorescences with salmon pink-colored ray florets; and strong flowering stems that hold the inflorescences upright.

Abstract: A new and distinct cultivar of Vinca plant named ‘24 Carat’, characterized by its compact, outwardly spreading to trailing plant habit; short internodes; densely foliated habit; strong and healthy leaves; developing leaves that are yellow in color becoming green with development; and good garden performance.