Patents by Inventor Richard Shao
Richard Shao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981734Abstract: The present disclosure provides isolated monoclonal antibodies (e.g., humanized and human monoclonal antibodies), or antigen-binding fragments thereof, that specifically bind to human natural killer cell inhibitory receptor group 2A (NKG2A) protein with high affinity and exhibit therapeutically desirable functional properties, such as for the treatment of, for example, cancer. Immunoconjugates, bispecific molecules, and pharmaceutical compositions comprising the anti-NKG2A antibodies of the invention are also provided. Nucleic acid molecules encoding the antibodies, expression vectors, host cells, and methods of treatment of, for example, cancer using the antibodies are further provided. Combination therapy, in which an anti-NKG2A antibody in the present disclosure is co-administered with at least one additional agent such as another antibody (e.g., anti-PD-1, anti-PD-L1, and/or anti-CTLA-4 antibodies), is also provided.Type: GrantFiled: February 10, 2022Date of Patent: May 14, 2024Assignee: Bristol-Myers Squibb CompanyInventors: Natalie Bezman, Alan J. Korman, Shrikant Deshpande, Amy D. Jhatakia, Richard Y. Huang, Guodong Chen, Ginger C. Rakestraw, Karla Ann Henning, Vangipuram S. Rangan, Christine Bee, Xiang Shao
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Patent number: 11952367Abstract: The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3K?) and are useful in the treatment of diseases related to the activity of PI3K? including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.Type: GrantFiled: March 25, 2022Date of Patent: April 9, 2024Assignee: Incyte CorporationInventors: Richard B. Sparks, Stacey Shepard, Andrew P. Combs, Andrew W. Buesking, Lixin Shao, Haisheng Wang, Nikoo Falahatpisheh
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Patent number: 11926630Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.Type: GrantFiled: November 30, 2021Date of Patent: March 12, 2024Assignee: Incyte CorporationInventors: Brent Douty, Andrew W. Buesking, David M. Burns, Andrew P. Combs, Nikoo Falahatpisheh, Ravi Kumar Jalluri, Daniel Levy, Padmaja Polam, Lixin Shao, Stacey Shepard, Artem Shvartsbart, Richard B. Sparks, Eddy W. Yue
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Publication number: 20230052856Abstract: An electric vehicle with magnetic induction power generating device includes an vehicle body, at least one battery pack installed inside the vehicle body, at least one power generation device electrically coupled to the at least one battery pack for providing electricity, a transmission device placed between the battery pack and the power generating device, and at least one motor for driving the electric vehicle, wherein the at least one power generating device can be coupled to at least one free-running wheel of the vehicle for converting a rotating energy of the at least one free-running wheel into electricity.Type: ApplicationFiled: August 11, 2021Publication date: February 16, 2023Inventor: Richard Shao Wei Chin
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Publication number: 20080060282Abstract: A structural insulated panel for use in a mine safe room, which includes a carbon foam core having a high ratio of compressive strength to density, desirable fire retardant properties, and resistance to environmental stress. The carbon foam structural insulated panel also includes a first layer and a second layer bound to a first surface and second surface of the carbon foam core.Type: ApplicationFiled: July 3, 2007Publication date: March 13, 2008Inventors: Douglas Miller, Richard Shao, Mark Segger, Yevegiy Griffin
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Publication number: 20070218272Abstract: A cement useful for bonding carbon articles or sealing the surfaces of carbon articles to provide a surface useful for, inter alia, composite tooling or other high temperature applications or for bonding of carbon articles together to form larger blocks.Type: ApplicationFiled: February 22, 2007Publication date: September 20, 2007Inventors: Richard Shao, Irwin Lewis
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Publication number: 20070172659Abstract: An oxidation-resistant carbon composite is formed from a protective coating applied over the surface of the carbon composite. The coating, itself, is formed through the application of a metal silicide containing medium to a carbon composite and subsequently heated to convert a portion of the metal silicide into silicon carbide and a metal carbide. The invention exhibits improved oxidation resistance especially in high temperature applications in the presence of oxidizing gases. Of particular interest is the application of the present invention for high friction disc brake systems for vehicles including aircraft.Type: ApplicationFiled: January 26, 2006Publication date: July 26, 2007Inventor: Richard Shao
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Publication number: 20070155847Abstract: An activated carbon foam material with improved graphitizability is formed by including an oxidation promoting metal-containing additive into the carbon foam and subsequently heat treating the foam in a reactive atmosphere. The oxidation promoting metal-containing additive greatly improves the development of the carbon foam's ramified pore system resulting in a carbon foam with a much greater surface area. This inventive foam may be created by introducing the oxidation promoting metal by way of an oxidation catalyst during the polymerization of the phenolic resin or as a inorganic chemical activating agent to the formed phenolic resin. The foam is then heated in a reactive atmosphere to produce an activated foam with a surface area of from about 200 m2/g to about 3000 m2/g.Type: ApplicationFiled: December 29, 2005Publication date: July 5, 2007Inventors: Douglas Miller, Irwin Lewis, Richard Shao, Terrence Pirro
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Publication number: 20070154702Abstract: A glassy carbon coated carbon foam material is formed by coating carbon foam with a glassy carbon layer. Carbon foam may be produced by carbonizing a phenolic or polyurethane foam at high temperatures in an inert atmosphere. The carbon foam is then machined to a desired shape and treated with a fine carbon or graphite powder to the surface. Subsequently a resin is applied to the surface of the carbon foam, and the coated carbon foam block is fired to carbonize the resin coating into a glassy carbon coating. The firing and coating are repeated until the desired coating thickness and surface properties are achieved.Type: ApplicationFiled: December 29, 2005Publication date: July 5, 2007Inventors: Douglas Miller, Irwin Lewis, Richard Shao
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Publication number: 20070154381Abstract: A carbon foam material with improved graphitizability is formed by including a graphitization promoting additive into the carbon foam. The graphitization promoting additive greatly improves the graphitic structure of the carbon foam resulting in a carbon foam with much greater thermal and electrical conductivities. This inventive foam may be created by introducing the graphitization promoting additive during the catalysis of a phenol-aldehyde mixture to a form phenolic resin or during the conversion of the phenolic resin to a phenolic foam. Alternatively, the graphitization promoting additive can be fixed onto a preformed carbon foam.Type: ApplicationFiled: December 29, 2005Publication date: July 5, 2007Inventors: Douglas Miller, Irwin Lewis, Richard Shao, Terrence Pirro
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Publication number: 20070155848Abstract: A carbon foam material with an improved oxidation resistance is created by blending formaldehyde with phenol to form a reactive mixture, polymerizing the reactive mixture with a non-oxidation promoting basic catalyst to form a resin article, foaming the resin article to create phenolic foam, and carbonizing the phenolic foam to create the carbon foam with an increased oxidation resistance. Specifically, the oxidation resistant carbon foam has a sodium content of approximately 0%. This inventive foam may also contain one or more oxidization inhibitors to impede the oxidation of the carbon foam when the foam is exposed to an oxidizing environment.Type: ApplicationFiled: December 29, 2005Publication date: July 5, 2007Inventors: Douglas Miller, Irwin Lewis, Richard Shao, Terrence Pirro, Orest Andrianowycz
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Publication number: 20070155849Abstract: A reinforced carbon foam material is formed from carbon fibers incorporated within a carbon foam's structure. First, carbon fiber bundles are combined with a liquid resol resin. The carbon fiber bundles separate into individual carbon fiber filaments and disperse throughout the liquid resol resin. Second, the carbon fiber resin mixture is foamed thus fixing the carbon fibers in a permanent spatial arrangement within the phenolic foam. The foam is then carbonized to create a carbon fiber reinforced foam with improved graphitic characteristics as well as increased strength. Optionally, various additives can be introduced simultaneously with the addition of the carbon fiber bundles into the liquid resol, which can improve the graphitic nature of the final carbon foam material and/or increase the foam's resistance to oxidation.Type: ApplicationFiled: December 29, 2005Publication date: July 5, 2007Inventors: Douglas Miller, Irwin Lewis, Richard Shao, Mehmet Yazici
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Publication number: 20070148434Abstract: A structural insulated panel for use in a mine safe room, which includes a carbon foam core having a high ratio of compressive strength to density, desirable fire retardant properties, and resistance to environmental stress. The carbon foam structural insulated panel also includes a first layer and a second layer bound to a first surface and second surface of the carbon foam core.Type: ApplicationFiled: April 19, 2006Publication date: June 28, 2007Inventors: Douglas Miller, Richard Shao, Mark Segger, Yevgeniy Griffin
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Publication number: 20070141344Abstract: A laminate sandwich structure useful for, inter alia, decking for naval vessels, which includes a core formed of carbon foam having a ratio of compressive strength to density of at least about 7000 psi/g/cc.Type: ApplicationFiled: March 3, 2006Publication date: June 21, 2007Inventors: Douglas Miller, Irwin Lewis, Richard Shao
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Publication number: 20070132126Abstract: A method of forming a carbon fiber reinforced carbon composite articles includes the steps of: (a) selecting carbon fiber bundles that have a sizing material that is soluble in a selected dispersing fluid; (b) mixing the selected carbon bundles and other blend components in a dispersing fluid so as to debundle the carbon fibers and to produce a slurry of blend components in which the individual carbon fibers are substantially randomly oriented and uniformly distributed throughout; and (c) removing the dispersing fluid either prior to or during the process of forming of the solids of the slurry into a carbon fiber reinforced carbon composite article having individual carbon fibers substantially randomly oriented and uniformly distributed throughout.Type: ApplicationFiled: December 14, 2005Publication date: June 14, 2007Inventors: Richard Shao, Terrence Pirro
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Publication number: 20060192311Abstract: A process for preparing graphite articles is presented. In particular, the process includes employing a particulate fraction comprising at least about 35 weight percent coke, coal or combinations thereof having a diameter such that a major fraction of it passes through a 0.25 mm to 25 mm mesh screen. The particulate fraction is mixed with a liquid or solid pitch binder, to form a stock blend; the stock blend is extruded to form a green stock; the green stock is baked to form a carbonized stock; and the carbonized stock is graphitized. The stock blend further includes carbon fibers added after mixing of the particulate fraction and pitch has begun.Type: ApplicationFiled: June 8, 2005Publication date: August 31, 2006Inventors: James Kortovich, Richard Shao, Irwin Lewis, Richard Lewis, Dai Huang
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Publication number: 20060159905Abstract: A sealant useful for sealing the surfaces of carbon foams to provide a surface useful for, inter alia, composite tooling or other high temperature applications or for bonding of carbon foams together to form larger blocks.Type: ApplicationFiled: May 25, 2005Publication date: July 20, 2006Inventors: Richard Shao, Douglas Miller, Irwin Lewis, Robert Mercuri
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Publication number: 20050013339Abstract: An induction furnace capable of operation at temperatures of over 3100° C. has a cooling assembly (60), which is selectively mounted to an upper end of the furnace wall (76). The cooling assembly includes a dome (62), which is actively cooled by cooling water coils (68). During the cool-down portion of a furnace run, cooling initially proceeds naturally, by conduction of heat away from the hot zone through a furnace insulation layer (58). Once the temperature within the furnace hot zone (20) reaches about 1500° C., a lifting mechanism (80), mounted to the dome, raises a cap (16) of the furnace slightly, allowing hot gases from the hot zone to mix with cooler gas in the dome. This speeds up cooling of the hot zone, reducing cool-down times significantly, without the need for encumbering the furnace itself with valves or other complex cooling mechanisms which have to be replaced periodically.Type: ApplicationFiled: March 3, 2004Publication date: January 20, 2005Inventors: Douglas Miller, Werner Ruoff, Allan Intermill, Stephen Strong, Thomas Thoman, Richard Shao