Patents by Inventor Richard T. Choh
Richard T. Choh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6949117Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: GrantFiled: January 29, 2004Date of Patent: September 27, 2005Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Patent number: 6802858Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: GrantFiled: January 31, 2001Date of Patent: October 12, 2004Assignee: C.R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Publication number: 20040186557Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: ApplicationFiled: January 29, 2004Publication date: September 23, 2004Applicant: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Patent number: 6786929Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.Type: GrantFiled: November 21, 2001Date of Patent: September 7, 2004Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Patent number: 6733488Abstract: The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressure sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, by its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug.Type: GrantFiled: December 5, 2002Date of Patent: May 11, 2004Assignee: C.R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Richard T. Choh, Robert Cafferata
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Patent number: 6709425Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: GrantFiled: January 31, 2001Date of Patent: March 23, 2004Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Publication number: 20030078561Abstract: The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressure sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, but its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug.Type: ApplicationFiled: December 5, 2002Publication date: April 24, 2003Inventors: Richard A. Gambale, Stephen J. Forcucci, Richard T. Choh, Robert Cafferata
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Patent number: 6517527Abstract: The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressures sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, by its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug.Type: GrantFiled: June 25, 2001Date of Patent: February 11, 2003Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Richard T. Choh, Robert Cafferata
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Patent number: 6458092Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: GrantFiled: September 30, 1998Date of Patent: October 1, 2002Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Patent number: 6432126Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.Type: GrantFiled: September 30, 1998Date of Patent: August 13, 2002Assignee: C.R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Publication number: 20020032476Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.Type: ApplicationFiled: November 21, 2001Publication date: March 14, 2002Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Patent number: 6331185Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.Type: GrantFiled: September 30, 1998Date of Patent: December 18, 2001Assignee: C.R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Publication number: 20010037086Abstract: The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressure sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, but its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug.Type: ApplicationFiled: June 25, 2001Publication date: November 1, 2001Inventors: Richard A. Gambale, Stephen J. Forcucci, Richard T. Choh, Robert Cafferata
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Patent number: 6251079Abstract: The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressure sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, by its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug.Type: GrantFiled: September 30, 1998Date of Patent: June 26, 2001Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Richard T. Choh, Robert Cafferata
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Publication number: 20010004690Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: ApplicationFiled: January 31, 2001Publication date: June 21, 2001Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Publication number: 20010004683Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: ApplicationFiled: January 31, 2001Publication date: June 21, 2001Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Patent number: 6110144Abstract: The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet.Type: GrantFiled: July 26, 1999Date of Patent: August 29, 2000Assignee: Medtronic AVE, Inc.Inventors: Richard T. Choh, John R. Fagan, Stephen J. Forcucci
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Patent number: 6063057Abstract: The invention relates to a syringe device for limiting the pressure of inflation fluid injected into a balloon catheter. The device includes a cylindrical housing having a proximal end and a distal end. A piston is received within and reciprocally movable between the distal end and the proximal end of the housing. A shaft having a proximal end and a distal end is received within an opening at the proximal end of the housing. The distal end of the shaft is coupled to the piston and the proximal end of the shaft is coupled via a slip clutch device to a hand knob. At least a portion of the external surface of the shaft is fitted with a screw thread, which may be selectively engaged with a complementary screw thread fitted either within the opening at the proximal end of the housing or a collar coupled to the housing.Type: GrantFiled: June 1, 1998Date of Patent: May 16, 2000Assignee: Medtronic AVE, Inc.Inventor: Richard T. Choh
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Patent number: 5993416Abstract: The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet.Type: GrantFiled: January 15, 1998Date of Patent: November 30, 1999Assignee: Medtronic AVE, Inc.Inventors: Richard T. Choh, John R. Fagan, Stephen J. Forcucci