Abstract: The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

Abstract: The present invention relates to a nutritional supplement for use by oral administration to a human for ameliorating adverse medical conditions deriving at least in part from a metabolic dysfunction and/or an intestinal dysfunction, which supplement is in a form suitable for oral administration and comprises a mixture of bioflavonoids which include at least 45% wt/wt naringin and at least 15% wt/wt of neohesperidin of the bioflavonoids present. The present invention also provides a method of treatment of the aforementioned medical conditions using the aforementioned nutritional supplements.

Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.

Abstract: A jug for a juicer has scaling features so that its contents may be isolated from the environment when it is not being filled or when used for pouring.

Abstract: A peripheral device, for use with a host, comprises one or more compute elements a security module and at least one encryption unit. The security module is configured to form a trusted execution environment on the peripheral device for processing sensitive data using sensitive code. The sensitive data and sensitive code are provided by a trusted computing entity which is in communication with the host computing device. The at least one encryption unit is configured to encrypt and decrypt data transferred between the trusted execution environment and the trusted computing entity via the host computing device. The security module is configured to compute and send an attestation to the trusted computing entity to attest that the sensitive code is in the trusted execution environment.

Abstract: Systems and methods permit or cause content to be displayed by a plurality of gaming displays, such as gaming machine displays and/or external displays. Content may be synchronously displayed by multiple gaming displays, such as one or more EGM displays and one or more external gaming displays, where the content which is displayed by the different displays may be the same or be different, and may be provided by a content controller and/or may be provided or triggered by a gaming machine. The systems and methods permit or cause content to be synchronously displayed across multiple gaming displays, such as in time and/or space. In some examples, the content is configured as a content “package” which is associated with one or more displays.

Abstract: A device may provision two or more servers, each of the servers including a network interface. In addition, the device may enable the network interface in each of the provisioned servers, create a shared volume, assign the shared volume to each of the provisioned servers, and enable a clustering application on each of the provisioned servers to form a cluster comprising the provisioned servers, the cluster having a heartbeat via the network interfaces.

Abstract: Systems and methods for generating one or more digital tokens for transmission among users is disclosed. The method comprises the steps of connecting a user to a computer based system via a set of login credentials. Further, the user is allowed to select one or more digital tokens to be sent to other users. Further, one or more users are selected as recipients. A value is determined for the one or more tokens to be sent to the other users. Furthermore, a set of content is input into a message associated with the one or more tokens. The tokens along with the message are transmitted from one user to the other. Upon successful transmission, the method updates one or more account balances for the one or more users and/or recipients.

Abstract: Disclosed is a process for the production of lithium ion conductive shaped particles, or precursors thereof, comprising: feeding a mixture of raw materials into a melting vessel, melting the raw materials in the melting vessel to form a molten mass, shaping the molten mass, and quenching the molten mass to produce the particles, wherein the cooling rate of the molten mass is sufficient to form a plurality of glass or glass ceramic particles and wherein the molten mass is shaped prior to or at the same time as being quenched by a fluid cooling medium.

Abstract: A hinged system includes a preassembled hinge module for pivotally coupling a first component to a second component. The preassembled hinge module includes a shaft, a torque element frictionally engaging the shaft, and a housing. The housing includes a cover, a side wall, and a rear wall that define an interior space enclosed within the housing. The interior space receives the torque element inside the housing. The cover defines a first aperture, and the rear wall defines a second aperture, the first aperture and the second aperture aligned with a pivot axis of the shaft. The shaft extends through at least the first aperture, the interior space, and the second aperture. The shaft is separate from, and configured to be mounted to, the first component. The housing is separate from, and configured to be mounted to, the second component.

Abstract: Techniques are disclosed herein for improving the accuracy of test data obtained outside of a clinical setting. Using the technologies described herein, different techniques can be utilized to analyze, score and adjust test data associated with one or more “at home” tests. In some examples, computing systems are utilized to generate quality scores indicating the accuracy of the test data associated with a particular biomarker. In other examples, an authorized user, such as a data manager can analyze the test data utilizing a user interface to generate scores and/or adjust the test data.

Abstract: The disclosure provides for a bottom hole assembly that comprises a stator solenoid winding transmitter assembly operable to generate a magnetic field. The stator solenoid winding transmitter assembly comprises a coil comprising a plurality of windings and a sleeve, wherein the coil is disposed within the sleeve. The bottom hole assembly further comprises a solenoid control assembly disposed adjacent to the stator solenoid winding transmitter assembly, wherein the solenoid control assembly is communicatively coupled to a controller and electrically connected to the coil and a mud motor comprising a rotor and a stator, wherein the stator solenoid winding transmitter assembly is disposed around the mud motor.

Abstract: The top surface of an insert abuts with a form, with a tube extending into an aperture and sliding on a form post in the form. A rod inserted through the form, form post and tube holds the insert in place while castable material is poured in. The form is inverted with the guard rail base inside, the rod can be slid out of the form, and the form is removed. The handle is gripped by a claw on the obtuse angled chassis of a transporter. A handle on the chassis can be pushed to raise the guard rail base and to move the guard rail base on the surface by wheels. The guard rail base can be placed upon a pad having notches in its border.

Abstract: Example implementations relate to deduplication operations in a storage system. An example includes receiving data units of a backup stream to be stored in a deduplication storage system; performing a first matching operation to match the data units against a first container index of a plurality of container indexes, where the plurality of container indexes comprise metadata indicating storage locations of data units previously stored in the persistent storage; calculating a first ratio indicating the amount of deduplication that occurred during the first matching operation against the first container index; and in response to a determination that the first ratio violates a condition with respect to local ratio history data of the first container index, identifying at least one portion of the backup stream as being potentially affected by a ransomware attack.

Abstract: The present disclosure relates to a heating system comprising: a heating element for heating a process medium; a DC power converter configured to receive an input direct-current voltage from a power supply and to deliver an output direct-current voltage to the heating element; a sensor arrangement configured to generate a first sensor output signal indicative of a thermodynamic parameter of the process medium or the heating element; and a controller configured to control the DC power converter based on the first sensor output signal.

Abstract: A heat exchanger assembly including an elongated tubular heat exchanger enclosure defining an interior chamber. A tube sheet is positioned within the interior chamber of the heat exchanger enclosure separating the interior chamber into a shell side and a channel side. The interior portion is configured to removably receive a tube bundle positioned within the shell side of the interior chamber. An annular sleeve member is positioned within the channel side of the interior chamber of the heat exchanger enclosure. An annular elastic torsion member is positioned within the channel side of the interior chamber of the heat exchanger such that the sleeve member is positioned between the tube sheet and the elastic torsion member. The elastic torsion member has an inner circumference deflectable relative to its outer circumference for torsioning the elastic torsion member.

Abstract: Systems and methods for drilling a wellbore include delivering electrical energy to a downhole end of the wellbore. A tapered drill string, with larger drill pipes connected in an up-hole portion with a turbine and an electrical generator and a smaller drill pipes coupled in downhole portion may be used to deliver the electrical power. A turbine and generator may be sufficiently sized to harvest the necessary hydraulic energy and safely operated in a subterranean environment. A lower portion system carried by the downhole portion of the drill string is electrically coupled to the generator through the downhole portion of the drill string to utilize the electric power provided by the electrical generator.

Abstract: A predictive model can be applied to data representing a history of events for an entity to compute a value indicative of an outcome related to a reference time for that entity. The effect of an event from an entity's history of events on an outcome for the entity at a reference time can vary based on the type of event and relative time of that event with respect to the reference time. The effect of an event from an entity's history of events on an outcome for the entity also can vary due to other characteristics of the entity in combination with the event. These effects are captured as weights. For an entity, functions of sets of events from the history of events are computed for the entity and a set of weights for events. The computed results are inputs to the predictive model.

Abstract: An apparatus includes an introducer defining an inner volume, a catheter, and a guide member. The having a proximal end portion and a distal end portion, with the catheter defining a lumen extending through the proximal end portion and the distal end portion of the catheter, and with the catheter configured to move between a first position, in which the catheter is disposed within the introducer, and a second position, in which at least the distal end portion of the catheter is distal to the introducer. The guide member is coupled to the introducer, with the guide member defining a lumen. A portion of the catheter is received within the lumen of the guide member when the catheter is in the first position, and the distal end portion of the catheter is distal to the guide member when the catheter is in the second position.