Patents by Inventor Richard Tillyer

Richard Tillyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydroxy open-acid salt of simvastatin
    Publication number: 20050119343
    Abstract: The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a crystalline hydrated form of the calcium salt of dihydroxy open acid simvastatin to a patient in need of such treatment. Methods for making the calcium salt of dihydroxy open acid simvastatin are also provided.
    Type: Application
    Filed: November 5, 2004
    Publication date: June 2, 2005
    Inventors: Richard Tillyer, Paul Reider, Edward Grabowski, Feng Xu, Robert Wenslow, Jose Vega, Richard Varsolona
  • Synthesis of acylated keto amides from sulfonyl amides
    Publication number: 20030083503
    Abstract: Acylated ketoamides are prepared from sulfonyl amides and aldehydes or their related derivatives by a step of 1
    Type: Application
    Filed: June 20, 2002
    Publication date: May 1, 2003
    Inventors: Doug E. Frantz, Lisa F. Frey, Karen Marcantonio, Jerry Anthony Murry, Richard Tillyer
  • Synthesis of substituted imidazoles
    Publication number: 20030055255
    Abstract: The present invention prepares imidazoles by the selective closure of a keto-amide to form the imidazolyl ring. In particular, the present invention selectively closes a keto-amide substituted with three rings to form a tri-substituted imidazole.
    Type: Application
    Filed: June 20, 2002
    Publication date: March 20, 2003
    Inventors: Karen Marcantonio, Lisa Frey, Doug Frantz, Jerry A. Murry, Richard Tillyer
  • Synthesis of ketosulfone esters
    Patent number: 6495713
    Abstract: This invention encompasses a process for making a compound of Formula A These compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammnatory agents.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: December 17, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Cheng Yi Chen, Weirong Chen, Paul O'Shea, Lushi Tan, Richard Tillyer, Feng Xu, Philippe Dagneau
  • Synthesis of ketosulfone esters
    Publication number: 20020143205
    Abstract: This invention encompasses a process for making a compound of Formula A 1
    Type: Application
    Filed: January 17, 2002
    Publication date: October 3, 2002
    Inventors: Cheng Yi Chen, Weirong Chen, Paul O'Shea, Lushi Tan, Richard Tillyer, Feng Xu, Philippe Dagneau
  • Process for making 2, 5-substituted pyridine
    Patent number: 6420565
    Abstract: 2-lithio-5-halopyridine is formed as a predominant component of a reaction mixture by reacting BuLi with 2,5-dihalopyridine in a non-coordinating solvent.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: July 16, 2002
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co
    Inventors: Paul O'Shea, Xin Wang, Richard Tillyer
  • Process for making 2, 5-Substituted pyridine
    Publication number: 20020016470
    Abstract: 2-lithio-5-halopyridine is formed as a predominant component of a reaction mixture by reacting BuLi with 2,5-dihalopyridine in a non-coordinating solvent.
    Type: Application
    Filed: February 27, 2001
    Publication date: February 7, 2002
    Inventors: Paul O'Shea, Xin Wang, Richard Tillyer
  • Process of making cox-2 inhibitors having a lactone bridge
    Patent number: 5585504
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: December 17, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Richard Desmond, Ulf Dolling, Ben Marcune, Richard Tillyer, David Tschaen