Patents by Inventor Richard Vachet

Richard Vachet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the comparison of protein higher order structures
    Patent number: 10031143
    Abstract: Some aspects of the disclosure include methods for comparing the higher order structures (HOS) of proteins using covalent labeling agents which allow for the direct comparison of changes in the HOS of protein therapeutics using mass spectrometry. The inventive methods can be used to access the effect of changing the process of producing and/or storing complex biologic compounds as well as determining if the HOS of a protein therapeutic has spontaneously changed during storage. Still other uses include comparing branded biologic therapeutic compounds to biosimilar compounds, and measuring changes in the aggregation states of proteins.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: July 24, 2018
    Inventors: Eric M. Graban, Richard Vachet, Yuping Zhou
  • METHOD FOR THE COMPARISON OF PROTEIN HIGHER ORDER STRUCTURES
    Publication number: 20170122963
    Abstract: Some aspects of the disclosure include methods for comparing the higher order structures (HOS) of proteins using covalent labeling agents which allow for the direct comparison of changes in the HOS of protein therapeutics using mass spectrometry. The inventive methods can be used to access the effect of changing the process of producing and/or storing complex biologic compounds as well as determining if the HOS of a protein therapeutic has spontaneously changed during storage. Still other uses include comparing branded biologic therapeutic compounds to biosimilar compounds, and measuring changes in the aggregation states of proteins.
    Type: Application
    Filed: May 21, 2015
    Publication date: May 4, 2017
    Inventors: Eric M. Graban, Richard Vachet, Yuping Zhou
  • Polymeric reverse micelles as selective extraction agents and related methods of MALDI-MS analysis
    Patent number: 8969026
    Abstract: Methods for liquid-liquid extraction, as can be effected using polymeric reverse micelles, such methods as can be used in conjunction with various mass spectrometric techniques.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: March 3, 2015
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Richard Vachet, Elamprakash N. Savariar, Marianny Y. Combariza
  • Polymeric Reverse Micelles as Selective Extraction Agents and Related Methods of MALDI-MS Analysis
    Publication number: 20120183983
    Abstract: Methods for liquid-liquid extraction, as can be effected using polymeric reverse micelles, such methods as can be used in conjunction with various mass spectrometric techniques.
    Type: Application
    Filed: August 11, 2008
    Publication date: July 19, 2012
    Inventors: Sankaran Thayumanavan, Richard Vachet, Elamprakash N. Savariar, Marianny Y. Combariza
  • Multiplexed tandem mass spectrometry
    Publication number: 20070120052
    Abstract: One or more methods for determination and/or deconvolution of complex mass spectra, using quadrupole ion trap mass spectrometry
    Type: Application
    Filed: November 28, 2006
    Publication date: May 31, 2007
    Inventors: Richard Vachet, Jonathan Wilson
  • Multiplexed tandem mass spectrometry
    Publication number: 20050263693
    Abstract: One or more methods for multiplexed determination and deconvolution of complex mass spectra, using quadrupole ion trap mass spectrometry
    Type: Application
    Filed: May 24, 2005
    Publication date: December 1, 2005
    Inventors: Richard Vachet, Jonathan Wilson