Abstract: A method for producing a porous flow-through element for use in an electrokinetic infusion pump is provided and generally includes providing a porous membrane that is entirely porous along both its length and width, treating the membrane by selectively inactivating portions of the membrane in a desired pattern to define active regions that allow fluid flow therethrough and inactive regions that do not, and laminating the treated membrane. Various techniques can be used to treat the membrane including, for example, applying a heated embossing die to the membrane, contacting selected portions of the membrane with laser energy, applying a pore-penetrating chemical to the membrane, and cutting and removing selected portions of the membrane. The resulting treated membrane can be laminated between opposed films having one or more perforations therethrough with each perforation being aligned with an active region to define a fluid flow pathway therebetween.